AutismKB 2.0

Annotation Detail for BRD2


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Basic Information Top
Gene Symbol:BRD2 ( D6S113E,DKFZp686N0336,FLJ31942,FSH,FSRG1,KIAA9001,NAT,RING3,RNF3 )
Gene Full Name: bromodomain containing 2
Band: 6p21.32
Quick LinksEntrez ID:6046; OMIM: 601540; Uniprot ID:BRD2_HUMAN; ENSEMBL ID: ENSG00000204256; HGNC ID: 1103
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst8 / 62319128
fetus135 / 564012239
neonate9 / 31097289
infant7 / 23620296
juvenile20 / 55556359
adult420 / 1939121216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma6 / 17475343
breast (mammary gland) tumor21 / 94178222
cervical tumor7 / 34366203
chondrosarcoma16 / 82823193
colorectal tumor36 / 114246315
esophageal tumor3 / 17290173
gastrointestinal tumor58 / 119369485
germ cell tumor56 / 263845212
glioma26 / 106883243
head and neck tumor49 / 136302359
kidney tumor2 / 6895929
leukemia18 / 95842187
liver tumor15 / 96359155
lung tumor29 / 103127281
lymphoma9 / 71755125
non-neoplasia12 / 97250123
normal612 / 3360307182
ovarian tumor16 / 76682208
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS23 / 125680183
prostate cancer23 / 102680223
retinoblastoma8 / 46356172
skin tumor6 / 12494948
soft tissue/muscle tissue tumor33 / 125191263
uterine tumor24 / 90257265
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland7 / 33197210
ascites16 / 40015399
bladder14 / 29757470
blood17 / 123478137
bone13 / 71655181
bone marrow14 / 48801286
brain218 / 1100989198
cervix7 / 48171145
connective tissue25 / 149255167
ear0 / 162120 
embryonic tissue28 / 215722129
esophagus3 / 20209148
eye21 / 21105499
heart9 / 89626100
intestine73 / 234472311
kidney37 / 211777174
larynx5 / 24145207
liver36 / 207743173
lung90 / 336974267
lymph8 / 44270180
lymph node19 / 91610207
mammary gland32 / 153271208
mouth23 / 67052343
muscle23 / 107715213
nerve5 / 15768317
ovary24 / 102051235
pancreas27 / 214812125
parathyroid4 / 20539194
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta32 / 280825113
prostate32 / 189345169
salivary gland2 / 2015599
skin22 / 210574104
spleen18 / 53952333
stomach43 / 96619445
testis102 / 330442308
thymus45 / 81131554
thyroid25 / 47473526
tonsil2 / 16999117
trachea18 / 52413343
umbilical cord7 / 13680511
uterus67 / 232878287
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208686_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts223.9
Adipocyte43.85
AdrenalCortex39
Adrenalgland56.35
Amygdala40.45
Appendix36.45
AtrioventricularNode20.1
BDCA4+_DentriticCells419.15
Bonemarrow46.15
BronchialEpithelialCells45.95
CD105+_Endothelial88.45
CD14+_Monocytes125.3
CD19+_BCells(neg._sel.)406
CD33+_Myeloid221.55
CD34+236.45
CD4+_Tcells290.55
CD56+_NKCells522.1
CD71+_EarlyErythroid78.45
CD8+_Tcells247.7
CardiacMyocytes44
Caudatenucleus41.4
Cerebellum49.1
CerebellumPeduncles57.55
CiliaryGanglion21.55
CingulateCortex41.1
Colorectaladenocarcinoma54.85
DorsalRootGanglion24.45
FetalThyroid62.3
Fetalbrain75.45
Fetalliver36.05
Fetallung54.55
GlobusPallidus28.8
Heart39.35
Hypothalamus58.25
Kidney37.05
Leukemia_chronicMyelogenousK-56247.25
Leukemia_promyelocytic-HL-6060.6
Leukemialymphoblastic(MOLT-4)106.25
Liver46.35
Lung90.95
Lymphnode65.75
Lymphoma_burkitts(Daudi)59.35
Lymphoma_burkitts(Raji)28.8
MedullaOblongata34.95
OccipitalLobe38.1
OlfactoryBulb58.25
Ovary27.1
Pancreas36.35
PancreaticIslet77.9
ParietalLobe32.8
Pituitary58.2
Placenta118.75
Pons32.55
PrefrontalCortex86.3
Prostate41.7
Salivarygland29.7
SkeletalMuscle41.5
Skin28.25
SmoothMuscle36.4
Spinalcord59.35
SubthalamicNucleus32.25
SuperiorCervicalGanglion21.75
TemporalLobe37.05
Testis123.7
TestisGermCell174.75
TestisIntersitial146.2
TestisLeydigCell58.5
TestisSeminiferousTubule85.15
Thalamus38.95
Thymus155.55
Thyroid78.1
Tongue30.5
Tonsil84.35
Trachea39
TrigeminalGanglion35.45
Uterus33.85
UterusCorpus27.9
WholeBlood143.75
Wholebrain37
colon42.45
pineal_day101.34
pineal_night115.98
retina81.8
small_intestine31.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P256898
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.06 ± 0.42
Basal Forebrain7.75 ± 0.36
Basal Part of Pons7.67 ± 0.31
Cerebellar Cortex7.6 ± 0.31
Cerebellar Nuclei7.9 ± 0.34
Claustrum8.2 ± 0.68
Epithalamus7.39 ± 0.26
Frontal Lobe7.58 ± 0.37
Globus Pallidus8.29 ± 0.16
Hypothalamus7.23 ± 0.27
Insula7.57 ± 0.42
Limbic Lobe8.03 ± 0.43
Mesencephalon7.69 ± 0.38
Myelencephalon7.77 ± 0.47
Occipital Lobe8.17 ± 0.5
Parietal Lobe7.76 ± 0.44
Pontine Tegmentum7.7 ± 0.39
Striatum7.94 ± 0.45
Subthalamus7.41 ± 0.21
Temporal Lobe7.64 ± 0.41
Thalamus7.77 ± 0.35
White Matter8.48 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Brd2CBCerebellum62.8
91.03
Brd2CTXCerebral cortex90.06
73.07
Brd2HIPHippocampal region62.71
100
Brd2HPFHippocampal formation67.67
85.74
Brd2HYHypothalamus34.44
27.24
Brd2LSXLateral septal complex46.37
38.5
Brd2MBMidbrain36.78
34.66
Brd2MYMedulla48.63
55.54
Brd2OLFOlfactory bulb83.34
80.19
Brd2PPons34.58
37.06
Brd2PALPallidum43.85
40.45
Brd2RHPRetrohippocampal region77
66.55
Brd2sAMYStriatum-like amygdalar nuclei52.86
39.45
Brd2STRStriatum63.35
48.73
Brd2STRdStriatum dorsal region63.89
49.65
Brd2STRvStriatum ventral region76.54
55.25
Brd2THThalamus54.26
52.21
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064270 18 529 546 AVHEQLAALSQGPISKPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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