AutismKB 2.0

Annotation Detail for RNF6


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Basic Information Top
Gene Symbol:RNF6 ( DKFZp686P0776 )
Gene Full Name: ring finger protein (C3H2C3 type) 6
Band: 13q12.13
Quick LinksEntrez ID:6049; OMIM: 604242; Uniprot ID:RNF6_HUMAN; ENSEMBL ID: ENSG00000127870; HGNC ID: 10069
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus23 / 56401240
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult83 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor8 / 26384530
glioma2 / 10688318
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal197 / 336030758
ovarian tumor2 / 7668226
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood12 / 12347897
bone3 / 7165541
bone marrow3 / 4880161
brain99 / 110098989
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye4 / 21105418
heart1 / 8962611
intestine5 / 23447221
kidney9 / 21177742
larynx1 / 2414541
liver7 / 20774333
lung12 / 33697435
lymph0 / 442700 
lymph node13 / 91610141
mammary gland8 / 15327152
mouth7 / 67052104
muscle4 / 10771537
nerve1 / 1576863
ovary3 / 10205129
pancreas20 / 21481293
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta25 / 28082589
prostate2 / 18934510
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach2 / 9661920
testis35 / 330442105
thymus13 / 81131160
thyroid2 / 4747342
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus10 / 23287842
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210932_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.85
Adipocyte11
AdrenalCortex16.6
Adrenalgland10.2
Amygdala11
Appendix15.45
AtrioventricularNode14.35
BDCA4+_DentriticCells11.8
Bonemarrow13.4
BronchialEpithelialCells10.75
CD105+_Endothelial11.05
CD14+_Monocytes12.1
CD19+_BCells(neg._sel.)11.55
CD33+_Myeloid13.8
CD34+13.35
CD4+_Tcells11
CD56+_NKCells12.1
CD71+_EarlyErythroid10.85
CD8+_Tcells10.15
CardiacMyocytes24.5
Caudatenucleus10.2
Cerebellum9.45
CerebellumPeduncles14.45
CiliaryGanglion14.5
CingulateCortex12
Colorectaladenocarcinoma11.35
DorsalRootGanglion11.35
FetalThyroid12.2
Fetalbrain10.85
Fetalliver10.3
Fetallung8.25
GlobusPallidus9.55
Heart21.35
Hypothalamus11.4
Kidney10.6
Leukemia_chronicMyelogenousK-5629.7
Leukemia_promyelocytic-HL-609.9
Leukemialymphoblastic(MOLT-4)8
Liver23.8
Lung12.25
Lymphnode9.05
Lymphoma_burkitts(Daudi)15.2
Lymphoma_burkitts(Raji)17.65
MedullaOblongata10.8
OccipitalLobe10.45
OlfactoryBulb9
Ovary9.1
Pancreas10.45
PancreaticIslet12.4
ParietalLobe15.2
Pituitary13.1
Placenta9.75
Pons12.55
PrefrontalCortex12.95
Prostate12.15
Salivarygland10.05
SkeletalMuscle27.45
Skin11.35
SmoothMuscle12.8
Spinalcord11.8
SubthalamicNucleus11.05
SuperiorCervicalGanglion28.15
TemporalLobe11.75
Testis9.55
TestisGermCell9.2
TestisIntersitial12.6
TestisLeydigCell12.55
TestisSeminiferousTubule9.95
Thalamus11.8
Thymus8.05
Thyroid12.25
Tongue14.35
Tonsil11.8
Trachea8.6
TrigeminalGanglion18.75
Uterus8.4
UterusCorpus11.75
WholeBlood11.65
Wholebrain8.2
colon10.25
pineal_day12.82
pineal_night13.1
retina13.25
small_intestine9.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P144881
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.82 ± 0.48
Basal Forebrain5.48 ± 0.18
Basal Part of Pons5.55 ± 0.29
Cerebellar Cortex5.65 ± 0.37
Cerebellar Nuclei5.66 ± 0.29
Claustrum5.76 ± 0.54
Epithalamus5.76 ± 0.55
Frontal Lobe5.74 ± 0.51
Globus Pallidus4.71 ± 0.41
Hypothalamus5.57 ± 0.34
Insula5.72 ± 0.26
Limbic Lobe5.74 ± 0.57
Mesencephalon5.57 ± 0.49
Myelencephalon5.64 ± 0.55
Occipital Lobe5.81 ± 0.39
Parietal Lobe5.77 ± 0.44
Pontine Tegmentum5.75 ± 0.45
Striatum5.71 ± 0.46
Subthalamus5.95 ± 0.09
Temporal Lobe5.72 ± 0.47
Thalamus5.61 ± 0.44
White Matter4.77 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rnf6CBCerebellum41.96
63.01
Rnf6CTXCerebral cortex100
98.49
Rnf6HIPHippocampal region61.04
99.37
Rnf6HPFHippocampal formation69.84
88.37
Rnf6HYHypothalamus54.73
47.53
Rnf6LSXLateral septal complex100
87.51
Rnf6MBMidbrain56.77
56.04
Rnf6MYMedulla57.41
72.45
Rnf6OLFOlfactory bulb70.46
65.19
Rnf6PPons53.65
65.5
Rnf6PALPallidum51.01
50.78
Rnf6RHPRetrohippocampal region85.41
77.21
Rnf6sAMYStriatum-like amygdalar nuclei43.96
33.16
Rnf6STRStriatum80.14
64.07
Rnf6STRdStriatum dorsal region86.4
70.31
Rnf6STRvStriatum ventral region70.63
53.35
Rnf6THThalamus97.1
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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