AutismKB 2.0

Annotation Detail for ROBO1


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Basic Information Top
Gene Symbol:ROBO1 ( DUTT1,FLJ21882,MGC131599,MGC133277,SAX3 )
Gene Full Name: roundabout, axon guidance receptor, homolog 1 (Drosophila)
Band: 3p12.3
Quick LinksEntrez ID:6091; OMIM: 602430; Uniprot ID:ROBO1_HUMAN; ENSEMBL ID: ENSG00000169855; HGNC ID: 10249
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus35 / 56401262
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor12 / 26384545
glioma1 / 1068839
head and neck tumor15 / 136302110
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal98 / 336030729
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain45 / 110098940
cervix1 / 4817120
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine4 / 23447217
kidney0 / 2117770 
larynx1 / 2414541
liver3 / 20774314
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth14 / 67052208
muscle3 / 10771527
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate5 / 18934526
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach6 / 9661962
testis15 / 33044245
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213194_at
Cell line Expression level Expression bar
721_B_lymphoblasts107.5
Adipocyte13.75
AdrenalCortex19.6
Adrenalgland8.65
Amygdala28.35
Appendix12.5
AtrioventricularNode9.6
BDCA4+_DentriticCells8.05
Bonemarrow10.4
BronchialEpithelialCells15.6
CD105+_Endothelial9.2
CD14+_Monocytes9.1
CD19+_BCells(neg._sel.)9.15
CD33+_Myeloid9.85
CD34+11.1
CD4+_Tcells8
CD56+_NKCells10.3
CD71+_EarlyErythroid8.85
CD8+_Tcells8.2
CardiacMyocytes47.9
Caudatenucleus11
Cerebellum8.25
CerebellumPeduncles12.15
CiliaryGanglion9.45
CingulateCortex11.8
Colorectaladenocarcinoma9.3
DorsalRootGanglion10.75
FetalThyroid10.4
Fetalbrain199.8
Fetalliver22.6
Fetallung13.3
GlobusPallidus8
Heart13.6
Hypothalamus44.95
Kidney8.5
Leukemia_chronicMyelogenousK-5628.85
Leukemia_promyelocytic-HL-607.5
Leukemialymphoblastic(MOLT-4)6.9
Liver13.9
Lung9.75
Lymphnode13.1
Lymphoma_burkitts(Daudi)11.5
Lymphoma_burkitts(Raji)11.6
MedullaOblongata8.95
OccipitalLobe18.15
OlfactoryBulb7.4
Ovary7.9
Pancreas8.25
PancreaticIslet9.65
ParietalLobe15.4
Pituitary30.65
Placenta7.85
Pons15.5
PrefrontalCortex23.95
Prostate11.35
Salivarygland7.5
SkeletalMuscle14.85
Skin11.9
SmoothMuscle87.4
Spinalcord15.75
SubthalamicNucleus12.65
SuperiorCervicalGanglion16.4
TemporalLobe12.8
Testis8.15
TestisGermCell14.45
TestisIntersitial8.95
TestisLeydigCell10.35
TestisSeminiferousTubule8.6
Thalamus24.65
Thymus7.7
Thyroid10.1
Tongue13.5
Tonsil17.2
Trachea8.3
TrigeminalGanglion12.4
Uterus10.2
UterusCorpus9.65
WholeBlood8.45
Wholebrain8.55
colon9.95
pineal_day11.92
pineal_night11.66
retina16.65
small_intestine9.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P80503
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.63 ± 0.46
Basal Forebrain6.57 ± 0.32
Basal Part of Pons5.53 ± 0.39
Cerebellar Cortex5.85 ± 0.26
Cerebellar Nuclei6.09 ± 0.37
Claustrum6.64 ± 0.74
Epithalamus5.56 ± 0.5
Frontal Lobe6.08 ± 0.44
Globus Pallidus6.8 ± 0.25
Hypothalamus5.83 ± 0.45
Insula6.29 ± 0.39
Limbic Lobe6.46 ± 0.5
Mesencephalon6.26 ± 0.46
Myelencephalon6.21 ± 0.53
Occipital Lobe6.18 ± 0.45
Parietal Lobe6.17 ± 0.52
Pontine Tegmentum6.51 ± 0.39
Striatum6.98 ± 0.47
Subthalamus6.38 ± 0.15
Temporal Lobe6.21 ± 0.42
Thalamus6.67 ± 0.4
White Matter6.7 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Robo1CBCerebellum1.04
1.82
Robo1CTXCerebral cortex10.04
9.42
Robo1HIPHippocampal region28.41
56.65
Robo1HPFHippocampal formation19.42
33.11
Robo1HYHypothalamus6.19
5.75
Robo1LSXLateral septal complex16.66
15.27
Robo1MBMidbrain11.52
13.51
Robo1MYMedulla3.96
7.11
Robo1OLFOlfactory bulb13.91
14
Robo1PPons9.37
13.04
Robo1PALPallidum16.61
16.94
Robo1RHPRetrohippocampal region8.4
8.77
Robo1sAMYStriatum-like amygdalar nuclei8.19
7.87
Robo1STRStriatum20.51
18.68
Robo1STRdStriatum dorsal region8.97
7.97
Robo1STRvStriatum ventral region60.96
51.8
Robo1THThalamus16.77
17.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00497573 32 828 859 SEPQFIQLDAHGNPVSPEDQVSLAQQISDVVK Peptide Atlas
ROBO1_HUMAN_453 6 453 458 PPPVIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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