AutismKB 2.0

Annotation Detail for ROCK1


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Basic Information Top
Gene Symbol:ROCK1 ( MGC131603,MGC43611,P160ROCK,PRO0435 )
Gene Full Name: Rho-associated, coiled-coil containing protein kinase 1
Band: 18q11.1
Quick LinksEntrez ID:6093; OMIM: 601702; Uniprot ID:ROCK1_HUMAN; ENSEMBL ID: ENSG00000067900; HGNC ID: 10251
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus32 / 56401256
neonate3 / 3109796
infant0 / 236200 
juvenile4 / 5555671
adult125 / 193912164
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor28 / 263845106
glioma3 / 10688328
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia7 / 9584273
liver tumor11 / 96359114
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal213 / 336030763
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer5 / 10268048
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood7 / 12347856
bone4 / 7165555
bone marrow4 / 4880181
brain49 / 110098944
cervix2 / 4817141
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue23 / 215722106
esophagus0 / 202090 
eye13 / 21105461
heart3 / 8962633
intestine15 / 23447263
kidney11 / 21177751
larynx1 / 2414541
liver13 / 20774362
lung18 / 33697453
lymph1 / 4427022
lymph node13 / 91610141
mammary gland12 / 15327178
mouth5 / 6705274
muscle10 / 10771592
nerve2 / 15768126
ovary1 / 1020519
pancreas13 / 21481260
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta20 / 28082571
prostate9 / 18934547
salivary gland0 / 201550 
skin12 / 21057456
spleen2 / 5395237
stomach2 / 9661920
testis14 / 33044242
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus14 / 23287860
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214578_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.05
Adipocyte16.25
AdrenalCortex16.2
Adrenalgland12.1
Amygdala13.7
Appendix24.8
AtrioventricularNode12.85
BDCA4+_DentriticCells22.45
Bonemarrow10.55
BronchialEpithelialCells29.25
CD105+_Endothelial13.4
CD14+_Monocytes26.95
CD19+_BCells(neg._sel.)19.3
CD33+_Myeloid35.1
CD34+16.95
CD4+_Tcells16.35
CD56+_NKCells18.05
CD71+_EarlyErythroid9.55
CD8+_Tcells45.65
CardiacMyocytes23.6
Caudatenucleus12.1
Cerebellum10
CerebellumPeduncles16
CiliaryGanglion11.1
CingulateCortex11.45
Colorectaladenocarcinoma15.95
DorsalRootGanglion12
FetalThyroid13.4
Fetalbrain13
Fetalliver12.2
Fetallung17.55
GlobusPallidus9.35
Heart10.2
Hypothalamus14
Kidney12.05
Leukemia_chronicMyelogenousK-56213.75
Leukemia_promyelocytic-HL-6019.15
Leukemialymphoblastic(MOLT-4)13.2
Liver17.3
Lung12.4
Lymphnode21.4
Lymphoma_burkitts(Daudi)27.85
Lymphoma_burkitts(Raji)20.95
MedullaOblongata12.25
OccipitalLobe10.7
OlfactoryBulb16.7
Ovary14.45
Pancreas11.05
PancreaticIslet14.8
ParietalLobe11.2
Pituitary16.2
Placenta10.5
Pons12.8
PrefrontalCortex16
Prostate12.9
Salivarygland13.45
SkeletalMuscle18.5
Skin11.8
SmoothMuscle19.15
Spinalcord13.85
SubthalamicNucleus11.6
SuperiorCervicalGanglion15.65
TemporalLobe7.35
Testis11.7
TestisGermCell25.75
TestisIntersitial30.8
TestisLeydigCell16.3
TestisSeminiferousTubule17.05
Thalamus10.3
Thymus8.55
Thyroid17.2
Tongue14.7
Tonsil14.1
Trachea11.35
TrigeminalGanglion20.45
Uterus21.05
UterusCorpus13.15
WholeBlood106.55
Wholebrain6.55
colon13.7
pineal_day15.58
pineal_night16.48
retina15.15
small_intestine11.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P105865
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.85 ± 0.78
Basal Forebrain9.52 ± 0.26
Basal Part of Pons9.77 ± 0.32
Cerebellar Cortex9.17 ± 0.46
Cerebellar Nuclei9.92 ± 0.29
Claustrum9.93 ± 0.5
Epithalamus8.89 ± 0.32
Frontal Lobe9.61 ± 0.55
Globus Pallidus10.12 ± 0.48
Hypothalamus9.34 ± 0.59
Insula9.56 ± 0.69
Limbic Lobe9.65 ± 0.55
Mesencephalon9.63 ± 0.48
Myelencephalon9.6 ± 0.59
Occipital Lobe9.53 ± 0.57
Parietal Lobe9.53 ± 0.49
Pontine Tegmentum9.39 ± 0.52
Striatum9.86 ± 0.54
Subthalamus9.59 ± 0.26
Temporal Lobe9.43 ± 0.63
Thalamus9.68 ± 0.43
White Matter9.53 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rock1CBCerebellum46.83
100
Rock1CTXCerebral cortex100
100
Rock1HIPHippocampal region96.59
100
Rock1HPFHippocampal formation96.49
100
Rock1HYHypothalamus36.34
32.08
Rock1LSXLateral septal complex61.61
58.48
Rock1MBMidbrain38.68
36
Rock1MYMedulla50
53.62
Rock1OLFOlfactory bulb80.85
87.39
Rock1PPons38.86
38.52
Rock1PALPallidum32.24
30.03
Rock1RHPRetrohippocampal region97.1
100
Rock1sAMYStriatum-like amygdalar nuclei70.82
58.52
Rock1STRStriatum52.27
43.13
Rock1STRdStriatum dorsal region46.88
38.34
Rock1STRvStriatum ventral region59.84
46.16
Rock1THThalamus41.71
41.39
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005863 10 311 320 NLICAFLTDR Peptide Atlas
ROCK1_HUMAN_1293 14 1293 1306 DMLLLACSQDEQKK PRIDE
ROCK1_HUMAN_310 10 310 319 NLICAFLTDR PRIDE
ROCK1_HUMAN_385 19 385 403 AFVGNQLPFVGFTYYSNRR PRIDE
ROCK1_HUMAN_630 9 630 638 ITSLQEEVK PRIDE
ROCK1_HUMAN_819 11 819 829 LLEFELAQLTK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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