AutismKB 2.0

Annotation Detail for RORA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RORA ( DKFZp686M2414,MGC119326,MGC119329,NR1F1,ROR1,ROR2,ROR3,RZR-ALPHA,RZRA )
Gene Full Name: RAR-related orphan receptor A
Band: 15q22.2
Quick LinksEntrez ID:6095; OMIM: 600825; Uniprot ID:RORA_HUMAN; ENSEMBL ID: ENSG00000069667; HGNC ID: 10258
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult69 / 193912135
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal209 / 336030762
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal17 / 33603075
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain35 / 110098931
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye13 / 21105461
heart0 / 896260 
intestine9 / 23447238
kidney12 / 21177756
larynx1 / 2414541
liver11 / 20774352
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth4 / 6705259
muscle14 / 107715129
nerve0 / 157680 
ovary1 / 1020519
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta10 / 28082535
prostate1 / 1893455
salivary gland0 / 201550 
skin76 / 210574360
spleen0 / 539520 
stomach1 / 9661910
testis7 / 33044221
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain7 / 11009896
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210479_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts27.8
Adipocyte4.25
AdrenalCortex7.15
Adrenalgland3.9
Amygdala4.4
Appendix6.05
AtrioventricularNode3.55
BDCA4+_DentriticCells4.9
Bonemarrow4.45
BronchialEpithelialCells4.15
CD105+_Endothelial4.3
CD14+_Monocytes4.5
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid5.4
CD34+5.3
CD4+_Tcells179.65
CD56+_NKCells323.2
CD71+_EarlyErythroid4.5
CD8+_Tcells195
CardiacMyocytes5.85
Caudatenucleus3.9
Cerebellum3.45
CerebellumPeduncles4.95
CiliaryGanglion3.9
CingulateCortex4.5
Colorectaladenocarcinoma4.3
DorsalRootGanglion3.6
FetalThyroid4.25
Fetalbrain4.2
Fetalliver3.75
Fetallung3.45
GlobusPallidus3.25
Heart5.8
Hypothalamus4.6
Kidney3.75
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.4
Liver5.85
Lung4.65
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.5
Lymphoma_burkitts(Raji)6.15
MedullaOblongata3.9
OccipitalLobe3.85
OlfactoryBulb3.35
Ovary2.95
Pancreas3.5
PancreaticIslet5
ParietalLobe4.65
Pituitary5
Placenta4.3
Pons4.15
PrefrontalCortex5.2
Prostate4.95
Salivarygland3.5
SkeletalMuscle5.5
Skin4.6
SmoothMuscle4.85
Spinalcord4.55
SubthalamicNucleus4
SuperiorCervicalGanglion5.35
TemporalLobe3.9
Testis3.7
TestisGermCell4.7
TestisIntersitial6.45
TestisLeydigCell4.45
TestisSeminiferousTubule8.5
Thalamus4.35
Thymus3.3
Thyroid5.25
Tongue4.55
Tonsil4.2
Trachea3.75
TrigeminalGanglion4.85
Uterus3.5
UterusCorpus4
WholeBlood4.65
Wholebrain3.55
colon4.35
pineal_day39.36
pineal_night22.16
retina5.15
small_intestine4.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P7721
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.53 ± 0.32
Basal Forebrain9.67 ± 0.2
Basal Part of Pons9.39 ± 0.46
Cerebellar Cortex10.66 ± 0.23
Cerebellar Nuclei10.05 ± 0.25
Claustrum8.89 ± 0.62
Epithalamus9.58 ± 0.53
Frontal Lobe9.65 ± 0.54
Globus Pallidus9.75 ± 0.82
Hypothalamus9.42 ± 0.7
Insula9.53 ± 0.44
Limbic Lobe9.37 ± 0.61
Mesencephalon10.04 ± 0.59
Myelencephalon10 ± 0.66
Occipital Lobe11.05 ± 0.83
Parietal Lobe10.13 ± 0.51
Pontine Tegmentum10.14 ± 0.53
Striatum9.89 ± 0.74
Subthalamus9.67 ± 0.31
Temporal Lobe9.7 ± 0.6
Thalamus11.12 ± 0.77
White Matter8.04 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
RoraCBCerebellum21.41
50
RoraCTXCerebral cortex34.48
20.66
RoraHIPHippocampal region15.05
9.21
RoraHPFHippocampal formation17.25
11.38
RoraHYHypothalamus8.2
4.63
RoraLSXLateral septal complex2.12
0.99
RoraMBMidbrain19.3
14.29
RoraMYMedulla21.88
16.59
RoraOLFOlfactory bulb28.01
17.94
RoraPPons16.2
11.61
RoraPALPallidum6.24
4.37
RoraRHPRetrohippocampal region21.14
14.11
RorasAMYStriatum-like amygdalar nuclei3.84
2.21
RoraSTRStriatum4.14
2.22
RoraSTRdStriatum dorsal region3.22
1.64
RoraSTRvStriatum ventral region7.05
3.74
RoraTHThalamus50
50
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved