AutismKB 2.0

Annotation Detail for RPL4


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Basic Information Top
Gene Symbol:RPL4 ( - )
Gene Full Name: ribosomal protein L4
Band: 15q22.31
Quick LinksEntrez ID:6124; OMIM: 180479; Uniprot ID:RL4_HUMAN; ENSEMBL ID: ENSG00000174444; HGNC ID: 10353
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body26 / 70761367
blastocyst23 / 62319369
fetus167 / 564012296
neonate23 / 31097739
infant5 / 23620211
juvenile56 / 555561007
adult975 / 1939121502
embryoid body198 / 707612798
blastocyst189 / 623193032
fetus203 / 564012359
neonate27 / 31097868
infant182 / 236207705
juvenile126 / 555562267
adult1129 / 1939121582
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor10 / 12794781
bladder carcinoma11 / 17475629
breast (mammary gland) tumor66 / 94178700
cervical tumor103 / 343662997
chondrosarcoma69 / 82823833
colorectal tumor141 / 1142461234
esophageal tumor6 / 17290347
gastrointestinal tumor105 / 119369879
germ cell tumor159 / 263845602
glioma30 / 106883280
head and neck tumor45 / 136302330
kidney tumor77 / 689591116
leukemia60 / 95842626
liver tumor58 / 96359601
lung tumor103 / 103127998
lymphoma90 / 717551254
non-neoplasia15 / 97250154
normal803 / 3360307238
ovarian tumor44 / 76682573
pancreatic tumor96 / 104616917
primitive neuroectodermal tumor of the CNS119 / 125680946
prostate cancer136 / 1026801324
retinoblastoma50 / 463561078
skin tumor60 / 124949480
soft tissue/muscle tissue tumor93 / 125191742
uterine tumor97 / 902571074
adrenal tumor18 / 127941406
bladder carcinoma10 / 17475572
breast (mammary gland) tumor125 / 941781327
cervical tumor290 / 343668438
chondrosarcoma14 / 82823169
colorectal tumor201 / 1142461759
esophageal tumor39 / 172902255
gastrointestinal tumor193 / 1193691616
germ cell tumor310 / 2638451174
glioma78 / 106883729
head and neck tumor67 / 136302491
kidney tumor55 / 68959797
leukemia77 / 95842803
liver tumor327 / 963593393
lung tumor347 / 1031273364
lymphoma309 / 717554306
non-neoplasia43 / 97250442
normal2244 / 3360307667
ovarian tumor68 / 76682886
pancreatic tumor103 / 104616984
primitive neuroectodermal tumor of the CNS398 / 1256803166
prostate cancer136 / 1026801324
retinoblastoma320 / 463566903
skin tumor228 / 1249491824
soft tissue/muscle tissue tumor233 / 1251911861
uterine tumor47 / 90257520
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland13 / 33197391
ascites21 / 40015524
bladder22 / 29757739
blood84 / 123478680
bone104 / 716551451
bone marrow31 / 48801635
brain255 / 1100989231
cervix104 / 481712158
connective tissue46 / 149255308
ear14 / 16212863
embryonic tissue96 / 215722445
esophagus6 / 20209296
eye99 / 211054469
heart29 / 89626323
intestine175 / 234472746
kidney88 / 211777415
larynx8 / 24145331
liver84 / 207743404
lung165 / 336974489
lymph51 / 442701152
lymph node36 / 91610392
mammary gland70 / 153271456
mouth16 / 67052238
muscle88 / 107715816
nerve3 / 15768190
ovary70 / 102051685
pancreas131 / 214812609
parathyroid6 / 20539292
pharynx18 / 41328435
pituitary gland11 / 16585663
placenta100 / 280825356
prostate170 / 189345897
salivary gland11 / 20155545
skin83 / 210574394
spleen12 / 53952222
stomach88 / 96619910
testis96 / 330442290
thymus17 / 81131209
thyroid26 / 47473547
tonsil13 / 16999764
trachea3 / 5241357
umbilical cord23 / 136801681
uterus140 / 232878601
vascular11 / 51780212
adipose tissue23 / 131061754
adrenal gland30 / 33197903
ascites62 / 400151549
bladder28 / 29757940
blood169 / 1234781368
bone46 / 71655641
bone marrow30 / 48801614
brain793 / 1100989720
cervix294 / 481716103
connective tissue39 / 149255261
ear1 / 1621261
embryonic tissue661 / 2157223064
esophagus43 / 202092127
eye429 / 2110542032
heart57 / 89626635
intestine300 / 2344721279
kidney119 / 211777561
larynx9 / 24145372
liver412 / 2077431983
lung438 / 3369741299
lymph254 / 442705737
lymph node39 / 91610425
mammary gland130 / 153271848
mouth20 / 67052298
muscle218 / 1077152023
nerve14 / 15768887
ovary101 / 102051989
pancreas128 / 214812595
parathyroid2 / 2053997
pharynx56 / 413281355
pituitary gland33 / 165851989
placenta173 / 280825616
prostate154 / 189345813
salivary gland27 / 201551339
skin269 / 2105741277
spleen54 / 539521000
stomach107 / 966191107
testis134 / 330442405
thymus55 / 81131677
thyroid29 / 47473610
tonsil64 / 169993764
trachea4 / 5241376
umbilical cord19 / 136801388
uterus201 / 232878863
vascular72 / 517801390
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211710_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts18942.95
Adipocyte5032.2
AdrenalCortex3661.9
Adrenalgland2254.1
Amygdala1972.6
Appendix4402.4
AtrioventricularNode1900.7
BDCA4+_DentriticCells11485.9
Bonemarrow2820.55
BronchialEpithelialCells10559.7
CD105+_Endothelial9088.6
CD14+_Monocytes7606.85
CD19+_BCells(neg._sel.)13067.5
CD33+_Myeloid8317.7
CD34+16009.6
CD4+_Tcells13542.95
CD56+_NKCells8717.25
CD71+_EarlyErythroid5703.95
CD8+_Tcells10197.65
CardiacMyocytes7695.45
Caudatenucleus3037.8
Cerebellum804.5
CerebellumPeduncles2643.7
CiliaryGanglion1468.6
CingulateCortex1980.9
Colorectaladenocarcinoma7772.5
DorsalRootGanglion1878.2
FetalThyroid5919.75
Fetalbrain7629.1
Fetalliver2673.55
Fetallung4532.2
GlobusPallidus1353.15
Heart1646.6
Hypothalamus3368.05
Kidney1572.6
Leukemia_chronicMyelogenousK-56210799.4
Leukemia_promyelocytic-HL-609062.4
Leukemialymphoblastic(MOLT-4)8001.25
Liver1612.5
Lung2567.2
Lymphnode6144.5
Lymphoma_burkitts(Daudi)20105.7
Lymphoma_burkitts(Raji)10070.7
MedullaOblongata2031.95
OccipitalLobe1538.45
OlfactoryBulb3145.15
Ovary6332.45
Pancreas4598.75
PancreaticIslet6523.1
ParietalLobe1746.75
Pituitary6546.15
Placenta2106.05
Pons1699.95
PrefrontalCortex4743.3
Prostate4184.95
Salivarygland4391.45
SkeletalMuscle3208.7
Skin3840.9
SmoothMuscle9645.6
Spinalcord3708.35
SubthalamicNucleus1934.85
SuperiorCervicalGanglion1335.8
TemporalLobe2333.4
Testis1913.3
TestisGermCell4241.55
TestisIntersitial3639.6
TestisLeydigCell2656.25
TestisSeminiferousTubule2872.8
Thalamus2824.2
Thymus3904.5
Thyroid5490
Tongue4194.4
Tonsil5830.3
Trachea3433.05
TrigeminalGanglion1418.05
Uterus4223.95
UterusCorpus4586.8
WholeBlood5985
Wholebrain1486.55
colon4509.4
pineal_day8505.8
pineal_night6953.34
retina5989.325
small_intestine5148.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P69431
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala12.29 ± 0.29
Basal Forebrain12.4 ± 0.12
Basal Part of Pons12.22 ± 0.3
Cerebellar Cortex12.18 ± 0.19
Cerebellar Nuclei12.18 ± 0.26
Claustrum12.43 ± 0.27
Epithalamus12.2 ± 0.25
Frontal Lobe12.01 ± 0.31
Globus Pallidus12.66 ± 0.09
Hypothalamus12.03 ± 0.43
Insula12.07 ± 0.23
Limbic Lobe12.03 ± 0.27
Mesencephalon12.12 ± 0.35
Myelencephalon12.07 ± 0.33
Occipital Lobe12.04 ± 0.16
Parietal Lobe12.02 ± 0.29
Pontine Tegmentum12.06 ± 0.2
Striatum12.47 ± 0.32
Subthalamus12.06 ± 0.37
Temporal Lobe12.04 ± 0.29
Thalamus11.87 ± 0.24
White Matter12.52 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rpl4CBCerebellum100
100
Rpl4CTXCerebral cortex100
100
Rpl4HIPHippocampal region100
100
Rpl4HPFHippocampal formation100
100
Rpl4HYHypothalamus100
100
Rpl4LSXLateral septal complex100
100
Rpl4MBMidbrain100
100
Rpl4MYMedulla100
100
Rpl4OLFOlfactory bulb100
100
Rpl4PPons100
100
Rpl4PALPallidum100
100
Rpl4RHPRetrohippocampal region100
100
Rpl4sAMYStriatum-like amygdalar nuclei100
100
Rpl4STRStriatum100
100
Rpl4STRdStriatum dorsal region100
100
Rpl4STRvStriatum ventral region100
100
Rpl4THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000201 19 2 20 ACARPLISVYSEKGESSGK Peptide Atlas
RL4_HUMAN_121 19 121 139 YAICSALAASALPALVMSK PRIDE
RL4_HUMAN_143 20 143 162 IEEVPELPLVVEDKVEGYKK PRIDE
RL4_HUMAN_20 9 20 28 NVTLPAVFK PRIDE
RL4_HUMAN_222 12 222 233 NIPGITLLNVSK PRIDE
RL4_HUMAN_248 10 248 257 FCIWTESAFR PRIDE
RL4_HUMAN_275 9 275 283 SNYNLPMHK PRIDE
RL4_HUMAN_28 17 28 44 KAPIRPDIVNFVHTNLR PRIDE
RL4_HUMAN_29 16 29 44 APIRPDIVNFVHTNLR PRIDE
RL4_HUMAN_313 11 313 323 VLKKNPLKNLR PRIDE
RL4_HUMAN_350 14 350 363 VDKAAAAAAALQAK PRIDE
RL4_HUMAN_353 11 353 363 AAAAAAALQAK PRIDE
RL4_HUMAN_46 25 46 70 NNRQPYAVSELAGHQTSAESWGTGR PRIDE
RL4_HUMAN_50 22 50 71 QPYAVSELAGHQTSAESWGTGR PRIDE
RL4_HUMAN_86 11 86 96 SGQGAFGNMCR PRIDE
RL4_HUMAN_87 11 87 97 SGQGAFGNMCR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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