AutismKB 2.0

Annotation Detail for RPS6


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Basic Information Top
Gene Symbol:RPS6 ( - )
Gene Full Name: ribosomal protein S6
Band: 9p22.1
Quick LinksEntrez ID:6194; OMIM: 180460; Uniprot ID:RS6_HUMAN; ENSEMBL ID: ENSG00000137154; HGNC ID: 10429
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body126 / 707611780
blastocyst52 / 62319834
fetus400 / 564012709
neonate47 / 310971511
infant6 / 23620254
juvenile44 / 55556791
adult1635 / 1939121843
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor25 / 127941954
bladder carcinoma28 / 174751602
breast (mammary gland) tumor156 / 941781656
cervical tumor56 / 343661629
chondrosarcoma70 / 82823845
colorectal tumor202 / 1142461768
esophageal tumor3 / 17290173
gastrointestinal tumor123 / 1193691030
germ cell tumor266 / 2638451008
glioma81 / 106883757
head and neck tumor94 / 136302689
kidney tumor94 / 689591363
leukemia101 / 958421053
liver tumor117 / 963591214
lung tumor186 / 1031271803
lymphoma232 / 717553233
non-neoplasia48 / 97250493
normal2816 / 3360307838
ovarian tumor94 / 766821225
pancreatic tumor79 / 104616755
primitive neuroectodermal tumor of the CNS110 / 125680875
prostate cancer251 / 1026802444
retinoblastoma104 / 463562243
skin tumor209 / 1249491672
soft tissue/muscle tissue tumor186 / 1251911485
uterine tumor155 / 902571717
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue16 / 131061220
adrenal gland34 / 331971024
ascites49 / 400151224
bladder30 / 297571008
blood209 / 1234781692
bone139 / 716551939
bone marrow101 / 488012069
brain385 / 1100989349
cervix61 / 481711266
connective tissue65 / 149255435
ear18 / 162121110
embryonic tissue392 / 2157221817
esophagus3 / 20209148
eye242 / 2110541146
heart102 / 896261138
intestine289 / 2344721232
kidney149 / 211777703
larynx14 / 24145579
liver212 / 2077431020
lung437 / 3369741296
lymph183 / 442704133
lymph node58 / 91610633
mammary gland171 / 1532711115
mouth18 / 67052268
muscle141 / 1077151309
nerve14 / 15768887
ovary143 / 1020511401
pancreas353 / 2148121643
parathyroid8 / 20539389
pharynx62 / 413281500
pituitary gland33 / 165851989
placenta146 / 280825519
prostate440 / 1893452323
salivary gland30 / 201551488
skin236 / 2105741120
spleen37 / 53952685
stomach120 / 966191241
testis150 / 330442453
thymus27 / 81131332
thyroid53 / 474731116
tonsil100 / 169995882
trachea1 / 5241319
umbilical cord49 / 136803581
uterus314 / 2328781348
vascular42 / 51780811
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209134_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9034.8
Adipocyte6118.55
AdrenalCortex3849.7
Adrenalgland2724.55
Amygdala2270.8
Appendix4498.85
AtrioventricularNode1671.65
BDCA4+_DentriticCells6150.95
Bonemarrow4235.25
BronchialEpithelialCells8739.6
CD105+_Endothelial6598.1
CD14+_Monocytes6330.35
CD19+_BCells(neg._sel.)8156.4
CD33+_Myeloid5423.75
CD34+10273.25
CD4+_Tcells10922.4
CD56+_NKCells7067.05
CD71+_EarlyErythroid6423.05
CD8+_Tcells9117.9
CardiacMyocytes5677.4
Caudatenucleus1714.45
Cerebellum1106.8
CerebellumPeduncles1284.3
CiliaryGanglion1084.4
CingulateCortex1381.55
Colorectaladenocarcinoma4145.25
DorsalRootGanglion1771.95
FetalThyroid6277.8
Fetalbrain4115.15
Fetalliver4300.95
Fetallung6000.7
GlobusPallidus783.6
Heart841.45
Hypothalamus3444.4
Kidney2587
Leukemia_chronicMyelogenousK-5625038.9
Leukemia_promyelocytic-HL-608266.05
Leukemialymphoblastic(MOLT-4)6828
Liver1704.95
Lung2840.7
Lymphnode6927.75
Lymphoma_burkitts(Daudi)9830.25
Lymphoma_burkitts(Raji)10676.85
MedullaOblongata2009.4
OccipitalLobe1768.1
OlfactoryBulb3449.7
Ovary5996.15
Pancreas6073.25
PancreaticIslet7407.6
ParietalLobe1358.65
Pituitary6826.2
Placenta3422
Pons1438.6
PrefrontalCortex3959.45
Prostate3649.05
Salivarygland5324.4
SkeletalMuscle1618.85
Skin3685.3
SmoothMuscle7651.45
Spinalcord4116.9
SubthalamicNucleus1095.3
SuperiorCervicalGanglion1086.45
TemporalLobe2059.65
Testis3688.8
TestisGermCell5051.4
TestisIntersitial4381.1
TestisLeydigCell3938.4
TestisSeminiferousTubule3747.55
Thalamus2019.05
Thymus5395.25
Thyroid7186.45
Tongue4956.9
Tonsil6213.35
Trachea4365.5
TrigeminalGanglion1768.75
Uterus5338.35
UterusCorpus5924.25
WholeBlood7684.4
Wholebrain1401.35
colon5199.2
pineal_day5590.2
pineal_night4554.98
retina5611.6
small_intestine6402
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P123563
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala13.65 ± 0.25
Basal Forebrain13.92 ± 0.18
Basal Part of Pons13.63 ± 0.21
Cerebellar Cortex13.54 ± 0.19
Cerebellar Nuclei13.94 ± 0.31
Claustrum13.5 ± 0.3
Epithalamus13.8 ± 0.28
Frontal Lobe13.45 ± 0.37
Globus Pallidus14.7 ± 0.22
Hypothalamus13.73 ± 0.33
Insula13.51 ± 0.2
Limbic Lobe13.28 ± 0.38
Mesencephalon13.63 ± 0.42
Myelencephalon13.56 ± 0.34
Occipital Lobe13.38 ± 0.25
Parietal Lobe13.47 ± 0.31
Pontine Tegmentum13.61 ± 0.3
Striatum13.87 ± 0.34
Subthalamus13.84 ± 0.23
Temporal Lobe13.51 ± 0.33
Thalamus13.57 ± 0.33
White Matter14.6 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rps6CBCerebellum46.86
84.66
Rps6CTXCerebral cortex100
100
Rps6HIPHippocampal region100
100
Rps6HPFHippocampal formation100
100
Rps6HYHypothalamus100
100
Rps6LSXLateral septal complex100
100
Rps6MBMidbrain100
100
Rps6MYMedulla83.7
100
Rps6OLFOlfactory bulb96.82
100
Rps6PPons97.55
100
Rps6PALPallidum86.16
100
Rps6RHPRetrohippocampal region100
100
Rps6sAMYStriatum-like amygdalar nuclei94.39
100
Rps6STRStriatum85.11
81.08
Rps6STRdStriatum dorsal region76.82
70.84
Rps6STRvStriatum ventral region98.97
90.8
Rps6THThalamus86.12
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002706 17 99 115 GCIVDANLSVLNLVIVK Peptide Atlas
RS6_HUMAN_0 0 0 0 MKLNISFPATGCQK PRIDE
RS6_HUMAN_115 16 115 130 KGEKDIPGLTDTTVPR PRIDE
RS6_HUMAN_119 12 119 130 DIPGLTDTTVPR PRIDE
RS6_HUMAN_120 12 120 131 DIPGLTDTTVPR PRIDE
RS6_HUMAN_14 8 14 21 LIEVDDER PRIDE
RS6_HUMAN_142 12 142 153 KLFNLSKEDDVR PRIDE
RS6_HUMAN_143 11 143 153 LFNLSKEDDVR PRIDE
RS6_HUMAN_143 12 143 154 KLFNLSKEDDVR PRIDE
RS6_HUMAN_159 11 159 169 KPLNKEGKKPR PRIDE
RS6_HUMAN_2 12 2 13 LNISFPATGCQK PRIDE
RS6_HUMAN_225 7 225 231 QEQIAKR PRIDE
RS6_HUMAN_239 11 239 249 ASTSKSESSQK PRIDE
RS6_HUMAN_31 15 31 45 MATEVAADALGEEWK PRIDE
RS6_HUMAN_31 20 31 50 MATEVAADALGEEWKGYVVR PRIDE
RS6_HUMAN_59 14 59 72 QGFPMKQGVLTHGR PRIDE
RS6_HUMAN_98 17 98 114 GCIVDANLSVLNLVIVK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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