AutismKB 2.0

Annotation Detail for RPS6KA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RPS6KA1 ( HU-1,MAPKAPK1A,RSK,RSK1 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 1
Band: 1p36.11
Quick LinksEntrez ID:6195; OMIM: 601684; Uniprot ID:KS6A1_HUMAN; ENSEMBL ID: ENSG00000117676; HGNC ID: 10430
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus9 / 56401215
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult115 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor14 / 119369117
germ cell tumor19 / 26384572
glioma4 / 10688337
head and neck tumor14 / 136302102
kidney tumor2 / 6895929
leukemia18 / 95842187
liver tumor3 / 9635931
lung tumor7 / 10312767
lymphoma28 / 71755390
non-neoplasia9 / 9725092
normal138 / 336030741
ovarian tumor11 / 76682143
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites5 / 40015124
bladder0 / 297570 
blood20 / 123478161
bone2 / 7165527
bone marrow7 / 48801143
brain19 / 110098917
cervix5 / 48171103
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye8 / 21105437
heart3 / 8962633
intestine23 / 23447298
kidney3 / 21177714
larynx0 / 241450 
liver8 / 20774338
lung25 / 33697474
lymph16 / 44270361
lymph node11 / 91610120
mammary gland4 / 15327126
mouth7 / 67052104
muscle4 / 10771537
nerve0 / 157680 
ovary11 / 102051107
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta3 / 28082510
prostate8 / 18934542
salivary gland0 / 201550 
skin11 / 21057452
spleen23 / 53952426
stomach9 / 9661993
testis17 / 33044251
thymus15 / 81131184
thyroid8 / 47473168
tonsil3 / 16999176
trachea4 / 5241376
umbilical cord1 / 1368073
uterus10 / 23287842
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203379_at
Cell line Expression level Expression bar
721_B_lymphoblasts221.55
Adipocyte31.6
AdrenalCortex55.15
Adrenalgland34.8
Amygdala25
Appendix42.15
AtrioventricularNode56.35
BDCA4+_DentriticCells494.95
Bonemarrow226.75
BronchialEpithelialCells146.35
CD105+_Endothelial239.2
CD14+_Monocytes537
CD19+_BCells(neg._sel.)148
CD33+_Myeloid350.8
CD34+118.35
CD4+_Tcells238.55
CD56+_NKCells652.7
CD71+_EarlyErythroid139.35
CD8+_Tcells172.55
CardiacMyocytes18.85
Caudatenucleus34.45
Cerebellum51.6
CerebellumPeduncles54.05
CiliaryGanglion53.8
CingulateCortex37.4
Colorectaladenocarcinoma35.65
DorsalRootGanglion63.95
FetalThyroid64.55
Fetalbrain36.65
Fetalliver31.6
Fetallung47.25
GlobusPallidus50.7
Heart85.2
Hypothalamus40.95
Kidney61.8
Leukemia_chronicMyelogenousK-56233.45
Leukemia_promyelocytic-HL-60123.65
Leukemialymphoblastic(MOLT-4)32.2
Liver79.15
Lung126.7
Lymphnode87.85
Lymphoma_burkitts(Daudi)248.75
Lymphoma_burkitts(Raji)162.25
MedullaOblongata34.45
OccipitalLobe31
OlfactoryBulb29.3
Ovary30.25
Pancreas45.2
PancreaticIslet40.8
ParietalLobe40.85
Pituitary51.7
Placenta30.8
Pons53.15
PrefrontalCortex44.65
Prostate64.75
Salivarygland42.25
SkeletalMuscle47.75
Skin46.45
SmoothMuscle35.85
Spinalcord44.55
SubthalamicNucleus53.45
SuperiorCervicalGanglion65.15
TemporalLobe35.3
Testis24.7
TestisGermCell30.8
TestisIntersitial25.2
TestisLeydigCell41.15
TestisSeminiferousTubule54.7
Thalamus53
Thymus65.4
Thyroid69.9
Tongue41.6
Tonsil82.9
Trachea40.75
TrigeminalGanglion87.5
Uterus24.25
UterusCorpus32.1
WholeBlood572.15
Wholebrain22.15
colon71.95
pineal_day48.72
pineal_night44.7
retina40.125
small_intestine68.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10978_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.51 ± 1.16
Basal Forebrain1.98 ± 0.24
Basal Part of Pons1.86 ± 0.55
Cerebellar Cortex2.68 ± 0.55
Cerebellar Nuclei2.82 ± 0.64
Claustrum2.76 ± 0.69
Epithalamus1.92 ± 0.82
Frontal Lobe1.94 ± 0.76
Globus Pallidus2.54 ± 0.73
Hypothalamus2.23 ± 0.84
Insula2.45 ± 1.48
Limbic Lobe2.07 ± 0.85
Mesencephalon2.25 ± 0.73
Myelencephalon2.14 ± 0.69
Occipital Lobe2.02 ± 0.65
Parietal Lobe2.1 ± 0.81
Pontine Tegmentum2.12 ± 0.82
Striatum1.95 ± 0.94
Subthalamus2.29 ± 0.78
Temporal Lobe1.93 ± 0.6
Thalamus2.05 ± 0.63
White Matter2.65 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rps6ka1CBCerebellum93.47
100
Rps6ka1CTXCerebral cortex22.65
16.32
Rps6ka1HIPHippocampal region7.34
7.04
Rps6ka1HPFHippocampal formation14.09
11.98
Rps6ka1HYHypothalamus5.15
4.21
Rps6ka1LSXLateral septal complex2.85
1.91
Rps6ka1MBMidbrain12.41
12.64
Rps6ka1MYMedulla22.19
26.93
Rps6ka1OLFOlfactory bulb22.8
17.23
Rps6ka1PPons13.6
15.81
Rps6ka1PALPallidum9.5
8.69
Rps6ka1RHPRetrohippocampal region24.82
18.42
Rps6ka1sAMYStriatum-like amygdalar nuclei3.55
2.72
Rps6ka1STRStriatum3.38
2.58
Rps6ka1STRdStriatum dorsal region2.15
1.73
Rps6ka1STRvStriatum ventral region6.62
4.43
Rps6ka1THThalamus10.97
9.4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KS6A1_HUMAN_0 0 0 0 DLKPENILLDEEGHIK PRIDE
KS6A1_HUMAN_186 16 186 201 DLKPENILLDEEGHIK PRIDE
KS6A1_HUMAN_278 16 278 293 LGMPQFLSTEAQSLLR PRIDE
PAp00000297 23 575 597 AENGLLMTPCYTANFVAPEVLKR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved