AutismKB 2.0

Annotation Detail for RPS6KA3


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Basic Information Top
Gene Symbol:RPS6KA3 ( CLS,HU-3,ISPK-1,MAPKAPK1B,MRX19,RSK,RSK2,S6K-alpha3,p90-RSK2,pp90RSK2 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 3
Band: Xp22.12
Quick LinksEntrez ID:6197; OMIM: 300075; Uniprot ID:KS6A3_HUMAN; ENSEMBL ID: ENSG00000177189; HGNC ID: 10432
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst0 / 623190 
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile8 / 55556143
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor8 / 9417884
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor10 / 26384537
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor14 / 96359145
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal153 / 336030745
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor9 / 12494972
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites5 / 40015124
bladder1 / 2975733
blood4 / 12347832
bone6 / 7165583
bone marrow3 / 4880161
brain10 / 11009899
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye6 / 21105428
heart2 / 8962622
intestine8 / 23447234
kidney11 / 21177751
larynx0 / 241450 
liver18 / 20774386
lung16 / 33697447
lymph0 / 442700 
lymph node2 / 9161021
mammary gland9 / 15327158
mouth3 / 6705244
muscle12 / 107715111
nerve0 / 157680 
ovary4 / 10205139
pancreas10 / 21481246
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta10 / 28082535
prostate13 / 18934568
salivary gland0 / 201550 
skin16 / 21057475
spleen4 / 5395274
stomach6 / 9661962
testis11 / 33044233
thymus3 / 8113136
thyroid6 / 47473126
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus10 / 23287842
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203843_at
Cell line Expression level Expression bar
721_B_lymphoblasts65.55
Adipocyte9.25
AdrenalCortex12
Adrenalgland8.05
Amygdala17.55
Appendix11.2
AtrioventricularNode9.2
BDCA4+_DentriticCells87.1
Bonemarrow10.75
BronchialEpithelialCells24.95
CD105+_Endothelial11.55
CD14+_Monocytes29.8
CD19+_BCells(neg._sel.)38.9
CD33+_Myeloid79.35
CD34+49.05
CD4+_Tcells186.3
CD56+_NKCells92.25
CD71+_EarlyErythroid11.05
CD8+_Tcells232.85
CardiacMyocytes17.3
Caudatenucleus9.6
Cerebellum8.5
CerebellumPeduncles15.2
CiliaryGanglion8.6
CingulateCortex17.15
Colorectaladenocarcinoma16.45
DorsalRootGanglion7.35
FetalThyroid10.15
Fetalbrain11.85
Fetalliver43.45
Fetallung24.3
GlobusPallidus8.6
Heart13.35
Hypothalamus13.45
Kidney8.15
Leukemia_chronicMyelogenousK-56210.8
Leukemia_promyelocytic-HL-6013.45
Leukemialymphoblastic(MOLT-4)10.25
Liver15.2
Lung11.8
Lymphnode25.8
Lymphoma_burkitts(Daudi)15.6
Lymphoma_burkitts(Raji)15.6
MedullaOblongata8.2
OccipitalLobe11.4
OlfactoryBulb8.4
Ovary8.75
Pancreas19.15
PancreaticIslet31.55
ParietalLobe10.55
Pituitary13.9
Placenta9.35
Pons9.95
PrefrontalCortex15.6
Prostate25.65
Salivarygland14.95
SkeletalMuscle13.2
Skin12.65
SmoothMuscle71.45
Spinalcord11.1
SubthalamicNucleus9.25
SuperiorCervicalGanglion12.25
TemporalLobe10.85
Testis7.65
TestisGermCell8.2
TestisIntersitial7.7
TestisLeydigCell9.6
TestisSeminiferousTubule7.55
Thalamus10.65
Thymus10.15
Thyroid18.35
Tongue11.85
Tonsil21.4
Trachea12.35
TrigeminalGanglion11.15
Uterus17.55
UterusCorpus9.5
WholeBlood72.2
Wholebrain8.55
colon19.95
pineal_day38.18
pineal_night44.46
retina14.35
small_intestine10.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_541_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.49 ± 0.52
Basal Forebrain5.87 ± 0.25
Basal Part of Pons5.74 ± 0.44
Cerebellar Cortex6.37 ± 0.34
Cerebellar Nuclei6.26 ± 0.54
Claustrum6.78 ± 0.45
Epithalamus5.88 ± 0.46
Frontal Lobe6 ± 0.44
Globus Pallidus5.34 ± 0.27
Hypothalamus5.92 ± 0.43
Insula6.24 ± 0.22
Limbic Lobe6.15 ± 0.42
Mesencephalon6.28 ± 0.57
Myelencephalon6.17 ± 0.48
Occipital Lobe6.64 ± 0.34
Parietal Lobe6.24 ± 0.4
Pontine Tegmentum6.22 ± 0.41
Striatum6.68 ± 0.48
Subthalamus6.31 ± 0.57
Temporal Lobe6.1 ± 0.36
Thalamus6.07 ± 0.37
White Matter5.14 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rps6ka3CBCerebellum17.31
20.38
Rps6ka3CTXCerebral cortex42.42
31.26
Rps6ka3HIPHippocampal region8.63
8.73
Rps6ka3HPFHippocampal formation11.76
10.7
Rps6ka3HYHypothalamus0.67
0.52
Rps6ka3LSXLateral septal complex2.08
1.49
Rps6ka3MBMidbrain4.17
3.97
Rps6ka3MYMedulla7.3
8.43
Rps6ka3OLFOlfactory bulb27.63
22.73
Rps6ka3PPons4.84
5.61
Rps6ka3PALPallidum3.98
3.16
Rps6ka3RHPRetrohippocampal region15.8
12.47
Rps6ka3sAMYStriatum-like amygdalar nuclei4.13
3.13
Rps6ka3STRStriatum31.51
22.77
Rps6ka3STRdStriatum dorsal region38.32
27.34
Rps6ka3STRvStriatum ventral region37.52
27.77
Rps6ka3THThalamus5.48
4.73
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KS6A3_HUMAN_142 9 142 150 LYLILDFLR PRIDE
KS6A3_HUMAN_192 16 192 207 DLKPENILLDEEGHIK PRIDE
KS6A3_HUMAN_284 16 284 299 LGMPQFLSPEAQSLLR PRIDE
KS6A3_HUMAN_285 16 285 300 LGMPQFLSPEAQSLLR PRIDE
KS6A3_HUMAN_310 13 310 322 LGAGPDGVEEIKR PRIDE
KS6A3_HUMAN_700 12 700 711 GAMAATYSALNR PRIDE
PAp00000297 23 570 592 AENGLLMTPCYTANFVAPEVLKR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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