AutismKB 2.0

Annotation Detail for RPS6KB1


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Basic Information Top
Gene Symbol:RPS6KB1 ( PS6K,S6K,S6K1,STK14A,p70(S6K)-alpha,p70-S6K,p70-alpha )
Gene Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Band: 17q23.1
Quick LinksEntrez ID:6198; OMIM: 608938; Uniprot ID:KS6B1_HUMAN; ENSEMBL ID: ENSG00000108443; HGNC ID: 10436
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus53 / 56401293
neonate2 / 3109764
infant1 / 2362042
juvenile4 / 5555671
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor19 / 94178201
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor13 / 26384549
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal178 / 336030752
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood6 / 12347848
bone1 / 7165513
bone marrow2 / 4880140
brain45 / 110098940
cervix2 / 4817141
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye8 / 21105437
heart4 / 8962644
intestine7 / 23447229
kidney9 / 21177742
larynx0 / 241450 
liver7 / 20774333
lung11 / 33697432
lymph2 / 4427045
lymph node12 / 91610130
mammary gland28 / 153271182
mouth5 / 6705274
muscle7 / 10771564
nerve1 / 1576863
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate5 / 18934526
salivary gland1 / 2015549
skin6 / 21057428
spleen1 / 5395218
stomach6 / 9661962
testis18 / 33044254
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus8 / 23287834
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204171_at
Cell line Expression level Expression bar
721_B_lymphoblasts22
Adipocyte6.1
AdrenalCortex6.8
Adrenalgland5.05
Amygdala6.15
Appendix6.4
AtrioventricularNode5.1
BDCA4+_DentriticCells11.5
Bonemarrow6.2
BronchialEpithelialCells6.05
CD105+_Endothelial13
CD14+_Monocytes6.6
CD19+_BCells(neg._sel.)8.45
CD33+_Myeloid11.65
CD34+17.05
CD4+_Tcells21.05
CD56+_NKCells35.65
CD71+_EarlyErythroid7.15
CD8+_Tcells10.8
CardiacMyocytes8.65
Caudatenucleus5.3
Cerebellum4.95
CerebellumPeduncles7
CiliaryGanglion4.95
CingulateCortex6.1
Colorectaladenocarcinoma6.2
DorsalRootGanglion4.9
FetalThyroid5.9
Fetalbrain5.95
Fetalliver5.3
Fetallung5.05
GlobusPallidus4.5
Heart8.55
Hypothalamus6.55
Kidney5.05
Leukemia_chronicMyelogenousK-5625.55
Leukemia_promyelocytic-HL-605.4
Leukemialymphoblastic(MOLT-4)4.95
Liver8.2
Lung6.3
Lymphnode5.2
Lymphoma_burkitts(Daudi)7.8
Lymphoma_burkitts(Raji)8.95
MedullaOblongata5.4
OccipitalLobe5.3
OlfactoryBulb4.8
Ovary4.75
Pancreas4.85
PancreaticIslet6.55
ParietalLobe6.35
Pituitary7.1
Placenta6.05
Pons5.75
PrefrontalCortex7.45
Prostate7.05
Salivarygland4.8
SkeletalMuscle7.65
Skin5.05
SmoothMuscle6.9
Spinalcord6.5
SubthalamicNucleus5.5
SuperiorCervicalGanglion7.5
TemporalLobe5.55
Testis5
TestisGermCell4.8
TestisIntersitial5.05
TestisLeydigCell6.05
TestisSeminiferousTubule4.95
Thalamus6.2
Thymus4.55
Thyroid7.7
Tongue6.2
Tonsil5.95
Trachea5.1
TrigeminalGanglion6.7
Uterus5.1
UterusCorpus5.6
WholeBlood7.8
Wholebrain4.95
colon6.2
pineal_day7.28
pineal_night7.36
retina7.225
small_intestine5.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P497226
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.46 ± 0.49
Basal Forebrain6.57 ± 0.18
Basal Part of Pons7.05 ± 0.14
Cerebellar Cortex6.99 ± 0.16
Cerebellar Nuclei6.85 ± 0.31
Claustrum6.54 ± 0.59
Epithalamus6.57 ± 0.26
Frontal Lobe6.84 ± 0.3
Globus Pallidus6.35 ± 0.15
Hypothalamus6.71 ± 0.35
Insula6.76 ± 0.32
Limbic Lobe6.55 ± 0.4
Mesencephalon6.67 ± 0.4
Myelencephalon6.63 ± 0.42
Occipital Lobe6.58 ± 0.47
Parietal Lobe6.83 ± 0.35
Pontine Tegmentum6.71 ± 0.38
Striatum6.26 ± 0.34
Subthalamus6.71 ± 0.65
Temporal Lobe6.74 ± 0.29
Thalamus6.69 ± 0.33
White Matter6.87 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rps6kb1CBCerebellum4.52
4.96
Rps6kb1CTXCerebral cortex3.98
2.74
Rps6kb1HIPHippocampal region22.11
21.28
Rps6kb1HPFHippocampal formation19.44
16.95
Rps6kb1HYHypothalamus1.39
0.9
Rps6kb1LSXLateral septal complex0.53
0.41
Rps6kb1MBMidbrain1.18
1.14
Rps6kb1MYMedulla3.84
4.57
Rps6kb1OLFOlfactory bulb15.78
12.59
Rps6kb1PPons5.69
6.59
Rps6kb1PALPallidum1.65
1.44
Rps6kb1RHPRetrohippocampal region14.57
10.49
Rps6kb1sAMYStriatum-like amygdalar nuclei2.92
2.11
Rps6kb1STRStriatum1.13
0.81
Rps6kb1STRdStriatum dorsal region0.59
0.44
Rps6kb1STRvStriatum ventral region2.45
1.58
Rps6kb1THThalamus2.15
1.62
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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