AutismKB 2.0

Annotation Detail for RPS6KB2


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Basic Information Top
Gene Symbol:RPS6KB2 ( KLS,P70-beta,P70-beta-1,P70-beta-2,S6K-beta2,S6K2,SRK,STK14B,p70(S6K)-beta,p70S6Kb )
Gene Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 2
Band: 11q13.2
Quick LinksEntrez ID:6199; OMIM: 608939; Uniprot ID:KS6B2_HUMAN; ENSEMBL ID: ENSG00000175634; HGNC ID: 10437
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus17 / 56401230
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult115 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor7 / 34366203
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor23 / 119369192
germ cell tumor8 / 26384530
glioma3 / 10688328
head and neck tumor6 / 13630244
kidney tumor5 / 6895972
leukemia9 / 9584293
liver tumor1 / 9635910
lung tumor16 / 103127155
lymphoma25 / 71755348
non-neoplasia4 / 9725041
normal141 / 336030741
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer8 / 10268077
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites7 / 40015174
bladder0 / 297570 
blood14 / 123478113
bone3 / 7165541
bone marrow3 / 4880161
brain30 / 110098927
cervix9 / 48171186
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye11 / 21105452
heart2 / 8962622
intestine8 / 23447234
kidney7 / 21177733
larynx0 / 241450 
liver5 / 20774324
lung27 / 33697480
lymph14 / 44270316
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle7 / 10771564
nerve0 / 157680 
ovary6 / 10205158
pancreas14 / 21481265
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta23 / 28082581
prostate11 / 18934558
salivary gland4 / 20155198
skin13 / 21057461
spleen0 / 539520 
stomach32 / 96619331
testis9 / 33044227
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203777_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts23.2
Adipocyte6.55
AdrenalCortex7.45
Adrenalgland5.45
Amygdala5.55
Appendix5.5
AtrioventricularNode5.4
BDCA4+_DentriticCells21.6
Bonemarrow6.95
BronchialEpithelialCells8.85
CD105+_Endothelial34.1
CD14+_Monocytes24.9
CD19+_BCells(neg._sel.)27.75
CD33+_Myeloid32.5
CD34+26.85
CD4+_Tcells25.6
CD56+_NKCells23
CD71+_EarlyErythroid34.6
CD8+_Tcells13.2
CardiacMyocytes15.7
Caudatenucleus6.8
Cerebellum4.9
CerebellumPeduncles7.8
CiliaryGanglion4.5
CingulateCortex6.7
Colorectaladenocarcinoma6.65
DorsalRootGanglion4.85
FetalThyroid9.75
Fetalbrain6.6
Fetalliver5.6
Fetallung4.85
GlobusPallidus5
Heart12.45
Hypothalamus6.4
Kidney5.3
Leukemia_chronicMyelogenousK-5626
Leukemia_promyelocytic-HL-605.2
Leukemialymphoblastic(MOLT-4)5.95
Liver22
Lung8.1
Lymphnode6
Lymphoma_burkitts(Daudi)8.25
Lymphoma_burkitts(Raji)9.1
MedullaOblongata6.55
OccipitalLobe5.35
OlfactoryBulb5
Ovary4.3
Pancreas5.25
PancreaticIslet7.05
ParietalLobe6.85
Pituitary7.7
Placenta7.95
Pons6.35
PrefrontalCortex7.75
Prostate7.7
Salivarygland4.65
SkeletalMuscle7.7
Skin5.1
SmoothMuscle8.55
Spinalcord7.05
SubthalamicNucleus6
SuperiorCervicalGanglion6.7
TemporalLobe13.75
Testis5.4
TestisGermCell5
TestisIntersitial5.45
TestisLeydigCell6.65
TestisSeminiferousTubule7.25
Thalamus8.15
Thymus5.3
Thyroid8.4
Tongue8.45
Tonsil6.35
Trachea4.9
TrigeminalGanglion6.65
Uterus5.45
UterusCorpus5.25
WholeBlood8.65
Wholebrain5.25
colon6.5
pineal_day10.3
pineal_night8.28
retina7.925
small_intestine6.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7844_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.35 ± 0.73
Basal Forebrain4.18 ± 0.39
Basal Part of Pons3.9 ± 0.86
Cerebellar Cortex4.11 ± 0.5
Cerebellar Nuclei4.05 ± 0.64
Claustrum4.52 ± 0.76
Epithalamus3.91 ± 0.55
Frontal Lobe3.78 ± 0.68
Globus Pallidus4.83 ± 0.44
Hypothalamus3.03 ± 0.91
Insula3.76 ± 0.8
Limbic Lobe4.15 ± 0.59
Mesencephalon4.1 ± 0.59
Myelencephalon4 ± 0.69
Occipital Lobe4.38 ± 0.61
Parietal Lobe4.09 ± 0.7
Pontine Tegmentum3.97 ± 0.7
Striatum4.2 ± 0.71
Subthalamus3.66 ± 1.03
Temporal Lobe3.82 ± 0.68
Thalamus3.97 ± 0.55
White Matter5.43 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rps6kb2CBCerebellum100
100
Rps6kb2CTXCerebral cortex100
100
Rps6kb2HIPHippocampal region100
100
Rps6kb2HPFHippocampal formation100
100
Rps6kb2HYHypothalamus100
100
Rps6kb2LSXLateral septal complex100
100
Rps6kb2MBMidbrain100
100
Rps6kb2MYMedulla100
100
Rps6kb2OLFOlfactory bulb100
100
Rps6kb2PPons100
100
Rps6kb2PALPallidum100
100
Rps6kb2RHPRetrohippocampal region100
100
Rps6kb2sAMYStriatum-like amygdalar nuclei100
100
Rps6kb2STRStriatum100
100
Rps6kb2STRdStriatum dorsal region100
100
Rps6kb2STRvStriatum ventral region100
100
Rps6kb2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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