AutismKB 2.0

Annotation Detail for RREB1


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Basic Information Top
Gene Symbol:RREB1 ( FINB,HNT,LZ321,RREB-1,Zep-1 )
Gene Full Name: ras responsive element binding protein 1
Band: 6p24.3
Quick LinksEntrez ID:6239; OMIM: 602209; Uniprot ID:RREB1_HUMAN; ENSEMBL ID: ENSG00000124782; HGNC ID: 10449
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus30 / 56401253
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia14 / 95842146
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal104 / 336030730
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood9 / 12347872
bone1 / 7165513
bone marrow1 / 4880120
brain7 / 11009896
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye8 / 21105437
heart3 / 8962633
intestine15 / 23447263
kidney3 / 21177714
larynx2 / 2414582
liver4 / 20774319
lung18 / 33697453
lymph0 / 442700 
lymph node6 / 9161065
mammary gland7 / 15327145
mouth3 / 6705244
muscle6 / 10771555
nerve0 / 157680 
ovary4 / 10205139
pancreas6 / 21481227
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate5 / 18934526
salivary gland0 / 201550 
skin18 / 21057485
spleen1 / 5395218
stomach4 / 9661941
testis5 / 33044215
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217411_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.2
Adipocyte4.25
AdrenalCortex4.65
Adrenalgland3.85
Amygdala4.45
Appendix4.25
AtrioventricularNode3.25
BDCA4+_DentriticCells4.7
Bonemarrow4.25
BronchialEpithelialCells4.15
CD105+_Endothelial4.3
CD14+_Monocytes4.65
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid5.45
CD34+5.3
CD4+_Tcells4.6
CD56+_NKCells5.05
CD71+_EarlyErythroid4
CD8+_Tcells4.05
CardiacMyocytes5.4
Caudatenucleus3.8
Cerebellum3.45
CerebellumPeduncles4.8
CiliaryGanglion3.1
CingulateCortex4.3
Colorectaladenocarcinoma4.2
DorsalRootGanglion3.25
FetalThyroid4.15
Fetalbrain4.15
Fetalliver3.65
Fetallung3.55
GlobusPallidus3.2
Heart5.65
Hypothalamus4.6
Kidney3.6
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.35
Liver5.65
Lung4.65
Lymphnode3.65
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)5.9
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.35
Ovary2.85
Pancreas3.4
PancreaticIslet4.55
ParietalLobe4.5
Pituitary4.95
Placenta4.35
Pons4.05
PrefrontalCortex5.25
Prostate5.4
Salivarygland3.45
SkeletalMuscle5.15
Skin3.3
SmoothMuscle4.95
Spinalcord4.55
SubthalamicNucleus4
SuperiorCervicalGanglion5.05
TemporalLobe3.95
Testis3.65
TestisGermCell3.6
TestisIntersitial4.35
TestisLeydigCell4.2
TestisSeminiferousTubule3.6
Thalamus4.35
Thymus3.35
Thyroid5.35
Tongue4.3
Tonsil4.15
Trachea3.55
TrigeminalGanglion5.15
Uterus3.45
UterusCorpus4.05
WholeBlood4.65
Wholebrain3.55
colon4.25
pineal_day5.28
pineal_night5.18
retina5.15
small_intestine4.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P59294
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.44 ± 1.18
Basal Forebrain2.57 ± 0.52
Basal Part of Pons2.62 ± 0.91
Cerebellar Cortex2.69 ± 0.72
Cerebellar Nuclei3.13 ± 0.54
Claustrum3.76 ± 0.83
Epithalamus3.37 ± 0.79
Frontal Lobe2.85 ± 0.92
Globus Pallidus3.91 ± 0.78
Hypothalamus2.64 ± 0.7
Insula2.6 ± 0.79
Limbic Lobe2.96 ± 0.96
Mesencephalon3.16 ± 0.83
Myelencephalon2.99 ± 0.87
Occipital Lobe3.1 ± 0.72
Parietal Lobe3.09 ± 0.93
Pontine Tegmentum3.07 ± 0.89
Striatum3.3 ± 0.88
Subthalamus2.88 ± 0.46
Temporal Lobe2.82 ± 0.93
Thalamus3.07 ± 0.76
White Matter3.52 ± 1.03
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rreb1CBCerebellum25.75
75.08
Rreb1CTXCerebral cortex22.45
17
Rreb1HIPHippocampal region47.62
74.7
Rreb1HPFHippocampal formation40.69
54.3
Rreb1HYHypothalamus19.49
16.24
Rreb1LSXLateral septal complex22.17
16.37
Rreb1MBMidbrain8.73
10.07
Rreb1MYMedulla11.05
12.36
Rreb1OLFOlfactory bulb46.88
44.1
Rreb1PPons8.87
10.07
Rreb1PALPallidum12.62
11
Rreb1RHPRetrohippocampal region30.86
30.04
Rreb1sAMYStriatum-like amygdalar nuclei58.98
49.78
Rreb1STRStriatum19.54
16.1
Rreb1STRdStriatum dorsal region9.75
6.4
Rreb1STRvStriatum ventral region30.32
29.77
Rreb1THThalamus68.22
66.14
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00068068 28 845 872 GEDSGCAALGDCKPLTAFLEPQNGFLHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018