AutismKB 2.0

Annotation Detail for RRM1


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Basic Information Top
Gene Symbol:RRM1 ( R1,RIR1,RR1 )
Gene Full Name: ribonucleotide reductase M1
Band: 11p15.4
Quick LinksEntrez ID:6240; OMIM: 180410; Uniprot ID:RIR1_HUMAN; ENSEMBL ID: ENSG00000167325; HGNC ID: 10451
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus172 / 564012304
neonate21 / 31097675
infant18 / 23620762
juvenile29 / 55556521
adult353 / 1939121182
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor30 / 94178318
cervical tumor15 / 34366436
chondrosarcoma13 / 82823156
colorectal tumor18 / 114246157
esophageal tumor31 / 172901792
gastrointestinal tumor33 / 119369276
germ cell tumor121 / 263845458
glioma15 / 106883140
head and neck tumor25 / 136302183
kidney tumor3 / 6895943
leukemia40 / 95842417
liver tumor12 / 96359124
lung tumor11 / 103127106
lymphoma13 / 71755181
non-neoplasia9 / 9725092
normal554 / 3360307164
ovarian tumor4 / 7668252
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS39 / 125680310
prostate cancer22 / 102680214
retinoblastoma14 / 46356302
skin tumor14 / 124949112
soft tissue/muscle tissue tumor43 / 125191343
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites20 / 40015499
bladder4 / 29757134
blood34 / 123478275
bone8 / 71655111
bone marrow30 / 48801614
brain242 / 1100989219
cervix19 / 48171394
connective tissue58 / 149255388
ear2 / 16212123
embryonic tissue19 / 21572288
esophagus31 / 202091533
eye23 / 211054108
heart15 / 89626167
intestine31 / 234472132
kidney60 / 211777283
larynx15 / 24145621
liver17 / 20774381
lung41 / 336974121
lymph10 / 44270225
lymph node13 / 91610141
mammary gland35 / 153271228
mouth21 / 67052313
muscle4 / 10771537
nerve1 / 1576863
ovary5 / 10205148
pancreas9 / 21481241
parathyroid4 / 20539194
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta44 / 280825156
prostate35 / 189345184
salivary gland1 / 2015549
skin37 / 210574175
spleen9 / 53952166
stomach12 / 96619124
testis103 / 330442311
thymus64 / 81131788
thyroid3 / 4747363
tonsil1 / 1699958
trachea11 / 52413209
umbilical cord3 / 13680219
uterus28 / 232878120
vascular18 / 51780347
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201476_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts171.6
Adipocyte4.85
AdrenalCortex5.1
Adrenalgland4.1
Amygdala5
Appendix5
AtrioventricularNode3.7
BDCA4+_DentriticCells11.45
Bonemarrow5.05
BronchialEpithelialCells17.9
CD105+_Endothelial69.75
CD14+_Monocytes5.05
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid6.3
CD34+57.25
CD4+_Tcells9.9
CD56+_NKCells7.7
CD71+_EarlyErythroid225.25
CD8+_Tcells4.95
CardiacMyocytes10.2
Caudatenucleus4.35
Cerebellum3.9
CerebellumPeduncles5.45
CiliaryGanglion3.4
CingulateCortex5
Colorectaladenocarcinoma6.5
DorsalRootGanglion3.75
FetalThyroid4.7
Fetalbrain4.85
Fetalliver7.35
Fetallung4.1
GlobusPallidus3.55
Heart6.15
Hypothalamus5.25
Kidney3.95
Leukemia_chronicMyelogenousK-5626.7
Leukemia_promyelocytic-HL-6016.35
Leukemialymphoblastic(MOLT-4)43.7
Liver6.4
Lung5.25
Lymphnode4.2
Lymphoma_burkitts(Daudi)9.7
Lymphoma_burkitts(Raji)7
MedullaOblongata4.4
OccipitalLobe4.35
OlfactoryBulb3.8
Ovary3.3
Pancreas3.95
PancreaticIslet5.95
ParietalLobe5.15
Pituitary5.75
Placenta5.1
Pons4.6
PrefrontalCortex6.1
Prostate5.7
Salivarygland3.9
SkeletalMuscle5.65
Skin3.75
SmoothMuscle7.75
Spinalcord5.15
SubthalamicNucleus4.4
SuperiorCervicalGanglion5.55
TemporalLobe4.45
Testis4.2
TestisGermCell4.95
TestisIntersitial4.7
TestisLeydigCell4.9
TestisSeminiferousTubule4.2
Thalamus4.9
Thymus4.15
Thyroid5.95
Tongue4.85
Tonsil6
Trachea4.05
TrigeminalGanglion4.8
Uterus4
UterusCorpus4.9
WholeBlood5.25
Wholebrain4
colon5.45
pineal_day5.98
pineal_night5.84
retina5.85
small_intestine4.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13934_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.47 ± 0.37
Basal Forebrain6.82 ± 0.33
Basal Part of Pons7.13 ± 0.14
Cerebellar Cortex7.09 ± 0.15
Cerebellar Nuclei6.95 ± 0.47
Claustrum6.69 ± 0.44
Epithalamus7.29 ± 0.2
Frontal Lobe6.74 ± 0.31
Globus Pallidus6.86 ± 0.27
Hypothalamus6.99 ± 0.28
Insula6.76 ± 0.28
Limbic Lobe6.48 ± 0.4
Mesencephalon6.77 ± 0.45
Myelencephalon6.72 ± 0.41
Occipital Lobe6.6 ± 0.44
Parietal Lobe6.74 ± 0.35
Pontine Tegmentum6.72 ± 0.33
Striatum6.27 ± 0.33
Subthalamus7.01 ± 0.37
Temporal Lobe6.78 ± 0.34
Thalamus6.79 ± 0.29
White Matter7.28 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rrm1CBCerebellum7.3
6.07
Rrm1CTXCerebral cortex6.32
2.91
Rrm1HIPHippocampal region4.42
3.49
Rrm1HPFHippocampal formation4.95
3.31
Rrm1HYHypothalamus3.95
2.09
Rrm1LSXLateral septal complex3.3
3.07
Rrm1MBMidbrain3.74
1.94
Rrm1MYMedulla13.72
6.86
Rrm1OLFOlfactory bulb11.49
5.15
Rrm1PPons5.19
2.2
Rrm1PALPallidum4.75
2.19
Rrm1RHPRetrohippocampal region6.01
3.18
Rrm1sAMYStriatum-like amygdalar nuclei4.11
1.56
Rrm1STRStriatum3.15
2.27
Rrm1STRdStriatum dorsal region2.22
2.1
Rrm1STRvStriatum ventral region5.23
2.7
Rrm1THThalamus2.34
1.24
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005940 25 657 681 NQIIACNGSIQSIPEIPDDLKQLYK Peptide Atlas
RIR1_HUMAN_1 6 1 6 MHVIKR PRIDE
RIR1_HUMAN_118 12 118 129 STLDIVLANKDR PRIDE
RIR1_HUMAN_163 11 163 173 VAERPQHMLMR PRIDE
RIR1_HUMAN_243 13 243 255 SAGGIGVAVSCIR PRIDE
RIR1_HUMAN_42 38 42 79 VIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAAR PRIDE
RIR1_HUMAN_479 18 479 496 IIDINYYPVPEACLSNKR PRIDE
RIR1_HUMAN_498 19 498 516 HRPIGIGVQGLADAFILMR PRIDE
RIR1_HUMAN_548 15 548 562 EQGPYETYEGSPVSK PRIDE
RIR1_HUMAN_649 8 649 656 GLWHEEMK PRIDE
RIR1_HUMAN_720 10 720 729 LTSMHFYGWK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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