AutismKB 2.0

Annotation Detail for RRM2


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Basic Information Top
Gene Symbol:RRM2 ( R2,RR2,RR2M )
Gene Full Name: ribonucleotide reductase M2
Band: 2p25.1
Quick LinksEntrez ID:6241; OMIM: 180390; Uniprot ID:RIR2_HUMAN; ENSEMBL ID: ENSG00000171848; HGNC ID: 10452
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst9 / 62319144
fetus115 / 564012203
neonate15 / 31097482
infant29 / 236201227
juvenile66 / 555561187
adult276 / 1939121142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor15 / 94178159
cervical tumor13 / 34366378
chondrosarcoma15 / 82823181
colorectal tumor36 / 114246315
esophageal tumor46 / 172902660
gastrointestinal tumor83 / 119369695
germ cell tumor96 / 263845363
glioma22 / 106883205
head and neck tumor41 / 136302300
kidney tumor4 / 6895958
leukemia21 / 95842219
liver tumor40 / 96359415
lung tumor14 / 103127135
lymphoma35 / 71755487
non-neoplasia6 / 9725061
normal316 / 336030794
ovarian tumor6 / 7668278
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS130 / 1256801034
prostate cancer10 / 10268097
retinoblastoma23 / 46356496
skin tumor45 / 124949360
soft tissue/muscle tissue tumor39 / 125191311
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites24 / 40015599
bladder6 / 29757201
blood44 / 123478356
bone12 / 71655167
bone marrow14 / 48801286
brain142 / 1100989128
cervix16 / 48171332
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus46 / 202092276
eye27 / 211054127
heart9 / 89626100
intestine57 / 234472243
kidney60 / 211777283
larynx0 / 241450 
liver50 / 207743240
lung28 / 33697483
lymph23 / 44270519
lymph node7 / 9161076
mammary gland17 / 153271110
mouth33 / 67052492
muscle30 / 107715278
nerve1 / 1576863
ovary9 / 10205188
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta53 / 280825188
prostate10 / 18934552
salivary gland2 / 2015599
skin61 / 210574289
spleen7 / 53952129
stomach52 / 96619538
testis85 / 330442257
thymus154 / 811311898
thyroid7 / 47473147
tonsil4 / 16999235
trachea1 / 5241319
umbilical cord2 / 13680146
uterus22 / 23287894
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201890_at
Cell line Expression level Expression bar
721_B_lymphoblasts2057.05
Adipocyte8.6
AdrenalCortex11.95
Adrenalgland8.35
Amygdala8.95
Appendix13.15
AtrioventricularNode10.6
BDCA4+_DentriticCells222
Bonemarrow185.65
BronchialEpithelialCells84
CD105+_Endothelial1618.05
CD14+_Monocytes9.75
CD19+_BCells(neg._sel.)9.45
CD33+_Myeloid112.95
CD34+646.7
CD4+_Tcells9.2
CD56+_NKCells65.3
CD71+_EarlyErythroid1507.8
CD8+_Tcells8.3
CardiacMyocytes24.4
Caudatenucleus8.1
Cerebellum7.4
CerebellumPeduncles11.75
CiliaryGanglion10.3
CingulateCortex9.2
Colorectaladenocarcinoma709.9
DorsalRootGanglion11.4
FetalThyroid9.45
Fetalbrain8.5
Fetalliver331.7
Fetallung7.35
GlobusPallidus7.5
Heart20.1
Hypothalamus9.4
Kidney8.75
Leukemia_chronicMyelogenousK-56239
Leukemia_promyelocytic-HL-60301.6
Leukemialymphoblastic(MOLT-4)504.35
Liver15.85
Lung9.9
Lymphnode7.45
Lymphoma_burkitts(Daudi)313.2
Lymphoma_burkitts(Raji)15.9
MedullaOblongata9.35
OccipitalLobe8.15
OlfactoryBulb7.1
Ovary7.35
Pancreas35.15
PancreaticIslet10
ParietalLobe11.8
Pituitary10.75
Placenta10.15
Pons9.55
PrefrontalCortex11.1
Prostate10.4
Salivarygland8.1
SkeletalMuscle24.15
Skin9.6
SmoothMuscle11.25
Spinalcord9.7
SubthalamicNucleus11.15
SuperiorCervicalGanglion29.6
TemporalLobe8.85
Testis7.75
TestisGermCell7.35
TestisIntersitial8.35
TestisLeydigCell9.85
TestisSeminiferousTubule7.8
Thalamus10
Thymus288.85
Thyroid10.65
Tongue13.2
Tonsil37.3
Trachea7.5
TrigeminalGanglion19.7
Uterus6.75
UterusCorpus11.6
WholeBlood9.75
Wholebrain7.2
colon537.55
pineal_day11.24
pineal_night10.94
retina11.2
small_intestine618.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P234196
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.46 ± 1.05
Basal Forebrain1.92 ± 0.22
Basal Part of Pons1.7 ± 0.78
Cerebellar Cortex1.81 ± 0.88
Cerebellar Nuclei2.19 ± 0.74
Claustrum2.77 ± 0.83
Epithalamus1.73 ± 0.63
Frontal Lobe1.7 ± 0.52
Globus Pallidus2.44 ± 0.27
Hypothalamus1.95 ± 0.67
Insula2.12 ± 0.94
Limbic Lobe1.93 ± 0.73
Mesencephalon2.07 ± 0.73
Myelencephalon1.92 ± 0.66
Occipital Lobe1.85 ± 0.43
Parietal Lobe1.93 ± 0.78
Pontine Tegmentum1.98 ± 0.67
Striatum2.04 ± 0.5
Subthalamus2.1 ± 0.77
Temporal Lobe1.84 ± 0.85
Thalamus1.88 ± 0.64
White Matter2.84 ± 1.08
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rrm2CBCerebellum1.22
2
Rrm2CTXCerebral cortex1.17
1.57
Rrm2HIPHippocampal region1.33
2.06
Rrm2HPFHippocampal formation1.16
1.73
Rrm2HYHypothalamus0.27
0.26
Rrm2LSXLateral septal complex4.09
8.62
Rrm2MBMidbrain0.32
0.5
Rrm2MYMedulla0.89
1.29
Rrm2OLFOlfactory bulb1.2
1.14
Rrm2PPons0.31
0.38
Rrm2PALPallidum0.89
0.92
Rrm2RHPRetrohippocampal region0.85
1.24
Rrm2sAMYStriatum-like amygdalar nuclei0.42
0.37
Rrm2STRStriatum1.39
2.79
Rrm2STRdStriatum dorsal region1.26
2.52
Rrm2STRvStriatum ventral region0.64
1.06
Rrm2THThalamus0.94
1.13
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00062864 13 62 74 AAAPGVEDEPLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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