AutismKB 2.0

Annotation Detail for RTN2


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Basic Information Top
Gene Symbol:RTN2 ( NSP2,NSPL1 )
Gene Full Name: reticulon 2
Band: 19q13.32
Quick LinksEntrez ID:6253; OMIM: 603183; Uniprot ID:RTN2_HUMAN; ENSEMBL ID: ENSG00000125744; HGNC ID: 10468
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus16 / 56401228
neonate0 / 310970 
infant6 / 23620254
juvenile4 / 5555671
adult64 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal110 / 336030732
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer0 / 1026800 
retinoblastoma4 / 4635686
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain33 / 110098929
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye13 / 21105461
heart2 / 8962622
intestine1 / 2344724
kidney4 / 21177718
larynx2 / 2414582
liver0 / 2077430 
lung10 / 33697429
lymph1 / 4427022
lymph node0 / 916100 
mammary gland11 / 15327171
mouth0 / 670520 
muscle25 / 107715232
nerve2 / 15768126
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate3 / 18934515
salivary gland1 / 2015549
skin9 / 21057442
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204217_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.95
Adipocyte6.45
AdrenalCortex6.65
Adrenalgland5.6
Amygdala9.35
Appendix7.05
AtrioventricularNode4.9
BDCA4+_DentriticCells7.1
Bonemarrow6.6
BronchialEpithelialCells5.7
CD105+_Endothelial6.1
CD14+_Monocytes7
CD19+_BCells(neg._sel.)6.65
CD33+_Myeloid8.15
CD34+7.75
CD4+_Tcells6.65
CD56+_NKCells7.25
CD71+_EarlyErythroid5.9
CD8+_Tcells5.8
CardiacMyocytes8.2
Caudatenucleus8.55
Cerebellum7.3
CerebellumPeduncles7.35
CiliaryGanglion4.55
CingulateCortex8.15
Colorectaladenocarcinoma6.55
DorsalRootGanglion5.35
FetalThyroid7
Fetalbrain14.2
Fetalliver5.6
Fetallung5.55
GlobusPallidus5.05
Heart15.05
Hypothalamus6.55
Kidney5.15
Leukemia_chronicMyelogenousK-5629.55
Leukemia_promyelocytic-HL-605.75
Leukemialymphoblastic(MOLT-4)4.85
Liver8.6
Lung7.1
Lymphnode5.35
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)10.5
MedullaOblongata7.5
OccipitalLobe6.75
OlfactoryBulb4.75
Ovary4.45
Pancreas5.05
PancreaticIslet6.55
ParietalLobe6.95
Pituitary7.35
Placenta10.85
Pons7
PrefrontalCortex16.25
Prostate8.25
Salivarygland5.15
SkeletalMuscle20.65
Skin4.95
SmoothMuscle15.05
Spinalcord6.95
SubthalamicNucleus7.05
SuperiorCervicalGanglion7.25
TemporalLobe6
Testis5.3
TestisGermCell5
TestisIntersitial5.4
TestisLeydigCell6.3
TestisSeminiferousTubule5.55
Thalamus6.7
Thymus4.8
Thyroid12.65
Tongue10
Tonsil6.1
Trachea5.5
TrigeminalGanglion6.95
Uterus5.15
UterusCorpus5.8
WholeBlood7.2
Wholebrain18.8
colon6.55
pineal_day8.18
pineal_night8
retina7.975
small_intestine6.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5679_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.14 ± 0.69
Basal Forebrain4.97 ± 0.56
Basal Part of Pons6.04 ± 0.49
Cerebellar Cortex5.46 ± 0.39
Cerebellar Nuclei4.77 ± 0.66
Claustrum4.86 ± 0.57
Epithalamus4.72 ± 0.4
Frontal Lobe5.72 ± 0.57
Globus Pallidus3.72 ± 0.61
Hypothalamus5.25 ± 0.44
Insula5.68 ± 0.25
Limbic Lobe5.43 ± 0.67
Mesencephalon5.15 ± 0.61
Myelencephalon5.32 ± 0.75
Occipital Lobe5.03 ± 0.63
Parietal Lobe5.44 ± 0.66
Pontine Tegmentum5.15 ± 0.64
Striatum5.02 ± 0.7
Subthalamus5.1 ± 0.61
Temporal Lobe5.59 ± 0.52
Thalamus5.49 ± 0.57
White Matter3.09 ± 0.89
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rtn2CBCerebellum3.42
3.72
Rtn2CTXCerebral cortex4.24
3.2
Rtn2HIPHippocampal region19.24
9.65
Rtn2HPFHippocampal formation15.68
9.06
Rtn2HYHypothalamus1.72
1.1
Rtn2LSXLateral septal complex0.69
0.58
Rtn2MBMidbrain1.76
1.75
Rtn2MYMedulla3.84
4.79
Rtn2OLFOlfactory bulb16.54
10.7
Rtn2PPons9.47
8.39
Rtn2PALPallidum2.54
2.06
Rtn2RHPRetrohippocampal region10.34
8.27
Rtn2sAMYStriatum-like amygdalar nuclei2.73
1.63
Rtn2STRStriatum1.73
1.06
Rtn2STRdStriatum dorsal region0.71
0.48
Rtn2STRvStriatum ventral region5.35
2.83
Rtn2THThalamus0.78
0.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00492116 21 497 517 QHQAQIDQYVGLVTNQLSHIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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