AutismKB 2.0

Annotation Detail for RYK


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Basic Information Top
Gene Symbol:RYK ( D3S3195,JTK5,JTK5A,RYK1 )
Gene Full Name: RYK receptor-like tyrosine kinase
Band: 3q22.2
Quick LinksEntrez ID:6259; OMIM: 600524; Uniprot ID:RYK_HUMAN; ENSEMBL ID: ENSG00000163785; HGNC ID: 10481
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus35 / 56401262
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult87 / 193912144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor17 / 26384564
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor5 / 9635951
lung tumor6 / 10312758
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal122 / 336030736
ovarian tumor8 / 76682104
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor15 / 124949120
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood2 / 12347816
bone4 / 7165555
bone marrow1 / 4880120
brain7 / 11009896
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye14 / 21105466
heart9 / 89626100
intestine13 / 23447255
kidney13 / 21177761
larynx0 / 241450 
liver7 / 20774333
lung22 / 33697465
lymph0 / 442700 
lymph node4 / 9161043
mammary gland5 / 15327132
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary12 / 102051117
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate14 / 18934573
salivary gland0 / 201550 
skin16 / 21057475
spleen0 / 539520 
stomach3 / 9661931
testis26 / 33044278
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus10 / 23287842
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216976_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.6
Adipocyte9.25
AdrenalCortex7.25
Adrenalgland5.55
Amygdala6.75
Appendix6.85
AtrioventricularNode5.15
BDCA4+_DentriticCells6.85
Bonemarrow6.55
BronchialEpithelialCells16.9
CD105+_Endothelial7.45
CD14+_Monocytes7.1
CD19+_BCells(neg._sel.)7.3
CD33+_Myeloid9.3
CD34+8.6
CD4+_Tcells10.35
CD56+_NKCells8.25
CD71+_EarlyErythroid6.15
CD8+_Tcells16.4
CardiacMyocytes12.9
Caudatenucleus6
Cerebellum5.3
CerebellumPeduncles7.45
CiliaryGanglion5.15
CingulateCortex6.55
Colorectaladenocarcinoma13.65
DorsalRootGanglion5.1
FetalThyroid6.55
Fetalbrain6.7
Fetalliver5.75
Fetallung8.25
GlobusPallidus4.8
Heart8.45
Hypothalamus6.8
Kidney5.4
Leukemia_chronicMyelogenousK-5626
Leukemia_promyelocytic-HL-607.1
Leukemialymphoblastic(MOLT-4)6.35
Liver8.8
Lung7.15
Lymphnode5.85
Lymphoma_burkitts(Daudi)8.4
Lymphoma_burkitts(Raji)9.4
MedullaOblongata5.85
OccipitalLobe5.8
OlfactoryBulb5.45
Ovary11.6
Pancreas5.35
PancreaticIslet6.95
ParietalLobe7
Pituitary7.7
Placenta7.85
Pons6.15
PrefrontalCortex7.7
Prostate7.6
Salivarygland5.3
SkeletalMuscle12.6
Skin5.2
SmoothMuscle17.65
Spinalcord7
SubthalamicNucleus6.05
SuperiorCervicalGanglion7.7
TemporalLobe6.05
Testis5.7
TestisGermCell12.1
TestisIntersitial9.25
TestisLeydigCell7.25
TestisSeminiferousTubule6.75
Thalamus6.65
Thymus5.2
Thyroid8.55
Tongue6.45
Tonsil6.5
Trachea5.6
TrigeminalGanglion8.85
Uterus5.8
UterusCorpus6
WholeBlood7.1
Wholebrain5.45
colon10
pineal_day8.3
pineal_night8.26
retina8.1
small_intestine6.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7815_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.87 ± 0.55
Basal Forebrain5.96 ± 0.19
Basal Part of Pons5.33 ± 0.3
Cerebellar Cortex5.95 ± 0.27
Cerebellar Nuclei5.47 ± 0.58
Claustrum5.73 ± 0.46
Epithalamus5.79 ± 0.44
Frontal Lobe5.5 ± 0.38
Globus Pallidus5.75 ± 0.32
Hypothalamus5.77 ± 0.5
Insula5.8 ± 0.55
Limbic Lobe5.55 ± 0.36
Mesencephalon5.73 ± 0.43
Myelencephalon5.56 ± 0.47
Occipital Lobe5.61 ± 0.36
Parietal Lobe5.68 ± 0.5
Pontine Tegmentum5.71 ± 0.44
Striatum5.5 ± 0.42
Subthalamus5.45 ± 0.41
Temporal Lobe5.6 ± 0.38
Thalamus5.45 ± 0.45
White Matter6.4 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
RykCBCerebellum1.33
1.25
RykCTXCerebral cortex0.58
0.44
RykHIPHippocampal region3.01
1.43
RykHPFHippocampal formation2.45
1.57
RykHYHypothalamus0.53
0.31
RykLSXLateral septal complex0.22
0.28
RykMBMidbrain1.11
0.82
RykMYMedulla6.03
5.91
RykOLFOlfactory bulb0.53
0.5
RykPPons8.41
7.67
RykPALPallidum0.32
0.2
RykRHPRetrohippocampal region1.33
1.55
RyksAMYStriatum-like amygdalar nuclei0.37
0.22
RykSTRStriatum0.17
0.11
RykSTRdStriatum dorsal region0.1
0.06
RykSTRvStriatum ventral region0.28
0.12
RykTHThalamus0.65
0.39
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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