AutismKB 2.0

Annotation Detail for BDNF


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Basic Information Top
Gene Symbol:BDNF ( MGC34632 )
Gene Full Name: brain-derived neurotrophic factor
Band: 11p14.1
Quick LinksEntrez ID:627; OMIM: 113505; Uniprot ID:BDNF_HUMAN; ENSEMBL ID: ENSG00000176697; HGNC ID: 1033
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult20 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal36 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix0 / 481710 
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye2 / 2110549
heart2 / 8962622
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206382_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.2
Adipocyte5.65
AdrenalCortex7.3
Adrenalgland5
Amygdala15.7
Appendix8.2
AtrioventricularNode5.5
BDCA4+_DentriticCells5.75
Bonemarrow6.05
BronchialEpithelialCells5.5
CD105+_Endothelial5.7
CD14+_Monocytes6.05
CD19+_BCells(neg._sel.)5.85
CD33+_Myeloid7
CD34+7.35
CD4+_Tcells5.85
CD56+_NKCells6.45
CD71+_EarlyErythroid5.45
CD8+_Tcells5.2
CardiacMyocytes15.6
Caudatenucleus5.25
Cerebellum7.1
CerebellumPeduncles17.25
CiliaryGanglion4.8
CingulateCortex7.7
Colorectaladenocarcinoma5.85
DorsalRootGanglion5.25
FetalThyroid5.75
Fetalbrain5.55
Fetalliver5.05
Fetallung4.45
GlobusPallidus7.4
Heart8.35
Hypothalamus12.4
Kidney5.15
Leukemia_chronicMyelogenousK-5625.25
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)4.45
Liver8.45
Lung6.4
Lymphnode4.8
Lymphoma_burkitts(Daudi)7.6
Lymphoma_burkitts(Raji)8.6
MedullaOblongata5.3
OccipitalLobe5.65
OlfactoryBulb4.5
Ovary4.15
Pancreas4.85
PancreaticIslet6.2
ParietalLobe6.45
Pituitary6.9
Placenta6.4
Pons5.7
PrefrontalCortex6.95
Prostate6.9
Salivarygland4.95
SkeletalMuscle7.55
Skin4.85
SmoothMuscle128.65
Spinalcord6.1
SubthalamicNucleus6.15
SuperiorCervicalGanglion8.1
TemporalLobe7.2
Testis4.95
TestisGermCell4.7
TestisIntersitial5.2
TestisLeydigCell5.85
TestisSeminiferousTubule5.15
Thalamus6.1
Thymus4.35
Thyroid7.05
Tongue6.55
Tonsil5.75
Trachea4.8
TrigeminalGanglion6.35
Uterus4.6
UterusCorpus5.45
WholeBlood6.15
Wholebrain6.05
colon5.7
pineal_day7
pineal_night6.94
retina7
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P127891
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.56 ± 0.78
Basal Forebrain4.45 ± 0.76
Basal Part of Pons8.46 ± 0.24
Cerebellar Cortex7.9 ± 0.21
Cerebellar Nuclei4.55 ± 0.83
Claustrum8.72 ± 0.61
Epithalamus5.11 ± 1.25
Frontal Lobe6.76 ± 0.92
Globus Pallidus3.91 ± 1.08
Hypothalamus6.19 ± 1.6
Insula7.35 ± 0.39
Limbic Lobe7.77 ± 0.98
Mesencephalon6.47 ± 1.54
Myelencephalon6.59 ± 1.38
Occipital Lobe6.91 ± 0.97
Parietal Lobe6.8 ± 0.79
Pontine Tegmentum6.21 ± 1.18
Striatum3.15 ± 1.4
Subthalamus6.7 ± 0.59
Temporal Lobe7.29 ± 0.6
Thalamus6.45 ± 0.96
White Matter3.55 ± 1.72
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
BdnfCBCerebellum2.06
2.43
BdnfCTXCerebral cortex27.68
22.1
BdnfHIPHippocampal region18.21
37.83
BdnfHPFHippocampal formation17.04
26.26
BdnfHYHypothalamus15.03
9.73
BdnfLSXLateral septal complex0.7
0.95
BdnfMBMidbrain9.48
6.15
BdnfMYMedulla4.82
3.28
BdnfOLFOlfactory bulb17.98
14.12
BdnfPPons8.2
5.94
BdnfPALPallidum3.05
2.12
BdnfRHPRetrohippocampal region14.31
9.9
BdnfsAMYStriatum-like amygdalar nuclei6.31
3.87
BdnfSTRStriatum2.36
1.83
BdnfSTRdStriatum dorsal region2.34
2.04
BdnfSTRvStriatum ventral region1.21
0.65
BdnfTHThalamus6.41
5.26
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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