AutismKB 2.0

Annotation Detail for SAFB


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Basic Information Top
Gene Symbol:SAFB ( DKFZp779C1727,HAP,HET,SAF-B1,SAFB1 )
Gene Full Name: scaffold attachment factor B
Band: 19p13.3
Quick LinksEntrez ID:6294; OMIM: 602895; Uniprot ID:SAFB1_HUMAN; ENSEMBL ID: ENSG00000160633; HGNC ID: 10520
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201747_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts58.1
Adipocyte6.35
AdrenalCortex6.9
Adrenalgland5.2
Amygdala6.75
Appendix6.5
AtrioventricularNode5.05
BDCA4+_DentriticCells31.7
Bonemarrow6.4
BronchialEpithelialCells6.15
CD105+_Endothelial8.65
CD14+_Monocytes7.4
CD19+_BCells(neg._sel.)13.6
CD33+_Myeloid8.15
CD34+23.4
CD4+_Tcells22.15
CD56+_NKCells30.1
CD71+_EarlyErythroid6.1
CD8+_Tcells20
CardiacMyocytes8.45
Caudatenucleus5.75
Cerebellum5.2
CerebellumPeduncles7.35
CiliaryGanglion4.65
CingulateCortex6.6
Colorectaladenocarcinoma7.45
DorsalRootGanglion5
FetalThyroid6.05
Fetalbrain6.35
Fetalliver5.6
Fetallung5.2
GlobusPallidus4.75
Heart8.15
Hypothalamus7
Kidney5.2
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.7
Leukemialymphoblastic(MOLT-4)6.75
Liver8.55
Lung8.4
Lymphnode5.5
Lymphoma_burkitts(Daudi)8.25
Lymphoma_burkitts(Raji)11.45
MedullaOblongata5.9
OccipitalLobe5.75
OlfactoryBulb5.05
Ovary4.3
Pancreas5.2
PancreaticIslet6.85
ParietalLobe6.8
Pituitary7.45
Placenta6.6
Pons6.15
PrefrontalCortex7.95
Prostate12.25
Salivarygland5.15
SkeletalMuscle7.65
Skin4.9
SmoothMuscle6.95
Spinalcord6.65
SubthalamicNucleus5.9
SuperiorCervicalGanglion7.3
TemporalLobe6.2
Testis5.25
TestisGermCell5.5
TestisIntersitial5.4
TestisLeydigCell6.25
TestisSeminiferousTubule5.5
Thalamus6.5
Thymus7.05
Thyroid8.15
Tongue6.35
Tonsil6.25
Trachea5.2
TrigeminalGanglion6.45
Uterus6.15
UterusCorpus5.6
WholeBlood7
Wholebrain6.25
colon6.3
pineal_day8.16
pineal_night7.94
retina7.525
small_intestine6.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P164649
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.49 ± 0.26
Basal Forebrain9.26 ± 0.21
Basal Part of Pons9.28 ± 0.27
Cerebellar Cortex9.1 ± 0.27
Cerebellar Nuclei9.08 ± 0.14
Claustrum9.78 ± 0.38
Epithalamus9.02 ± 0.2
Frontal Lobe9.03 ± 0.33
Globus Pallidus9.63 ± 0.19
Hypothalamus8.93 ± 0.31
Insula9.06 ± 0.33
Limbic Lobe9.32 ± 0.34
Mesencephalon9.18 ± 0.33
Myelencephalon9.18 ± 0.28
Occipital Lobe9.39 ± 0.3
Parietal Lobe9.26 ± 0.35
Pontine Tegmentum9.12 ± 0.35
Striatum9.24 ± 0.36
Subthalamus9.08 ± 0.06
Temporal Lobe9.14 ± 0.31
Thalamus9.09 ± 0.27
White Matter10.1 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SafbCBCerebellum52.76
68.48
SafbCTXCerebral cortex100
100
SafbHIPHippocampal region76.7
100
SafbHPFHippocampal formation83.59
100
SafbHYHypothalamus48.57
41.77
SafbLSXLateral septal complex71.99
57.9
SafbMBMidbrain66.11
63.73
SafbMYMedulla47.65
51.99
SafbOLFOlfactory bulb94.05
88.31
SafbPPons40.6
42.02
SafbPALPallidum59.78
58.3
SafbRHPRetrohippocampal region98.13
88.86
SafbsAMYStriatum-like amygdalar nuclei87.66
69.58
SafbSTRStriatum78.93
63.02
SafbSTRdStriatum dorsal region76.74
60.7
SafbSTRvStriatum ventral region85.88
68.99
SafbTHThalamus78.62
73.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001485 15 448 462 CYGFVTMSTAEEATK Peptide Atlas
SAFB1_HUMAN_2 28 2 29 AETLSGLGDSGAAGAAALSSASSETGTR PRIDE
SAFB1_HUMAN_53 8 53 60 NKSVLMER PRIDE

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018