AutismKB 2.0

Annotation Detail for MAPK12


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Basic Information Top
Gene Symbol:MAPK12 ( ERK3,ERK6,P38GAMMA,PRKM12,SAPK-3,SAPK3 )
Gene Full Name: mitogen-activated protein kinase 12
Band: 22q13.33
Quick LinksEntrez ID:6300; OMIM: 602399; Uniprot ID:MK12_HUMAN; ENSEMBL ID: ENSG00000188130; HGNC ID: 6874
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile10 / 55556179
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor3 / 17290173
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma5 / 10688346
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia27 / 95842281
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma11 / 71755153
non-neoplasia0 / 972500 
normal67 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS32 / 125680254
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood27 / 123478218
bone3 / 7165541
bone marrow0 / 488010 
brain48 / 110098943
cervix6 / 48171124
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus3 / 20209148
eye3 / 21105414
heart1 / 8962611
intestine0 / 2344720 
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle13 / 107715120
nerve1 / 1576863
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate6 / 18934531
salivary gland2 / 2015599
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206106_at
Cell line Expression level Expression bar
721_B_lymphoblasts67.35
Adipocyte15.8
AdrenalCortex29.7
Adrenalgland13.45
Amygdala16.2
Appendix18.9
AtrioventricularNode19.8
BDCA4+_DentriticCells13.55
Bonemarrow17.95
BronchialEpithelialCells14.15
CD105+_Endothelial11.9
CD14+_Monocytes14.75
CD19+_BCells(neg._sel.)12.65
CD33+_Myeloid17.9
CD34+20.45
CD4+_Tcells15.4
CD56+_NKCells16.35
CD71+_EarlyErythroid12.5
CD8+_Tcells9.15
CardiacMyocytes20.75
Caudatenucleus16.35
Cerebellum16.15
CerebellumPeduncles28.85
CiliaryGanglion19.75
CingulateCortex19.2
Colorectaladenocarcinoma19.55
DorsalRootGanglion23.25
FetalThyroid26.5
Fetalbrain17.2
Fetalliver13.2
Fetallung9.8
GlobusPallidus22.3
Heart24
Hypothalamus17.25
Kidney19.85
Leukemia_chronicMyelogenousK-56214.35
Leukemia_promyelocytic-HL-6058.45
Leukemialymphoblastic(MOLT-4)9.1
Liver16.15
Lung15.95
Lymphnode12.1
Lymphoma_burkitts(Daudi)71.25
Lymphoma_burkitts(Raji)133.3
MedullaOblongata13.6
OccipitalLobe23.5
OlfactoryBulb12.55
Ovary13.8
Pancreas14.45
PancreaticIslet14.25
ParietalLobe24.35
Pituitary26.3
Placenta9.8
Pons30.45
PrefrontalCortex18.65
Prostate13.75
Salivarygland16.3
SkeletalMuscle67.05
Skin23.5
SmoothMuscle18.15
Spinalcord18.4
SubthalamicNucleus18.65
SuperiorCervicalGanglion30.2
TemporalLobe40.7
Testis13.55
TestisGermCell13.05
TestisIntersitial13.9
TestisLeydigCell19.7
TestisSeminiferousTubule17.15
Thalamus23.75
Thymus8.65
Thyroid20.1
Tongue39.9
Tonsil17.05
Trachea11.55
TrigeminalGanglion27.25
Uterus12.9
UterusCorpus15.5
WholeBlood14.9
Wholebrain13.55
colon13.7
pineal_day17.3
pineal_night16.08
retina20.9
small_intestine14.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7613_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2 ± 1.03
Basal Forebrain1.51 ± 0.21
Basal Part of Pons1.33 ± 0.57
Cerebellar Cortex1.67 ± 0.82
Cerebellar Nuclei1.76 ± 0.75
Claustrum2.23 ± 0.72
Epithalamus1.14 ± 0.75
Frontal Lobe1.49 ± 0.7
Globus Pallidus1.88 ± 0.51
Hypothalamus1.66 ± 0.76
Insula1.55 ± 0.51
Limbic Lobe1.43 ± 0.7
Mesencephalon1.64 ± 0.73
Myelencephalon1.55 ± 0.67
Occipital Lobe1.29 ± 0.64
Parietal Lobe1.43 ± 0.74
Pontine Tegmentum1.53 ± 0.68
Striatum1.39 ± 0.51
Subthalamus1.63 ± 0.64
Temporal Lobe1.55 ± 0.7
Thalamus1.45 ± 0.62
White Matter1.5 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapk12CBCerebellum3.76
2.8
Mapk12CTXCerebral cortex0.72
0.4
Mapk12HIPHippocampal region0.16
0.32
Mapk12HPFHippocampal formation0.24
0.25
Mapk12HYHypothalamus0.18
0.1
Mapk12LSXLateral septal complex0.38
0.42
Mapk12MBMidbrain1.14
0.69
Mapk12MYMedulla7.32
3.54
Mapk12OLFOlfactory bulb1.53
1.37
Mapk12PPons4.67
2.43
Mapk12PALPallidum0.16
0.18
Mapk12RHPRetrohippocampal region0.35
0.17
Mapk12sAMYStriatum-like amygdalar nuclei0.26
0.14
Mapk12STRStriatum0.22
0.25
Mapk12STRdStriatum dorsal region0.19
0.2
Mapk12STRvStriatum ventral region0.26
0.4
Mapk12THThalamus0.16
0.17
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501354 26 300 325 VTAGEALAHPYFESLHDTEDEPQVQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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