AutismKB 2.0

Annotation Detail for SERPINB4


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Basic Information Top
Gene Symbol:SERPINB4 ( LEUPIN,PI11,SCCA-2,SCCA1,SCCA2 )
Gene Full Name: serpin peptidase inhibitor, clade B (ovalbumin), member 4
Band: 18q21.33
Quick LinksEntrez ID:6318; OMIM: 600518; Uniprot ID:SPB4_HUMAN; ENSEMBL ID: ENSG00000206073; HGNC ID: 10570
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor6 / 17290347
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal20 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow6 / 48801122
brain1 / 11009890 
cervix3 / 4817162
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus9 / 20209445
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx2 / 2414582
liver0 / 2077430 
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth5 / 6705274
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx8 / 41328193
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland2 / 2015599
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea15 / 52413286
umbilical cord0 / 136800 
uterus16 / 23287868
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209720_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.05
Adipocyte6.1
AdrenalCortex7.5
Adrenalgland5.55
Amygdala6.25
Appendix8.6
AtrioventricularNode7.65
BDCA4+_DentriticCells6.35
Bonemarrow6.7
BronchialEpithelialCells6.15
CD105+_Endothelial6.15
CD14+_Monocytes6.8
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid7.85
CD34+7.5
CD4+_Tcells6.4
CD56+_NKCells7.1
CD71+_EarlyErythroid6
CD8+_Tcells5.65
CardiacMyocytes9.85
Caudatenucleus5.6
Cerebellum5.15
CerebellumPeduncles7.9
CiliaryGanglion5.15
CingulateCortex6.6
Colorectaladenocarcinoma6.25
DorsalRootGanglion6.85
FetalThyroid6.2
Fetalbrain5.95
Fetalliver5.55
Fetallung4.8
GlobusPallidus5.05
Heart9.6
Hypothalamus6.55
Kidney5.6
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)4.8
Liver9.15
Lung6.8
Lymphnode5.15
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)9.5
MedullaOblongata5.75
OccipitalLobe5.55
OlfactoryBulb4.85
Ovary5
Pancreas5.25
PancreaticIslet6.8
ParietalLobe7
Pituitary7.25
Placenta6.15
Pons6.55
PrefrontalCortex7.45
Prostate7.2
Salivarygland5.2
SkeletalMuscle9.5
Skin5.6
SmoothMuscle7.05
Spinalcord6.65
SubthalamicNucleus5.95
SuperiorCervicalGanglion9.8
TemporalLobe5.85
Testis5.3
TestisGermCell4.95
TestisIntersitial6
TestisLeydigCell6.85
TestisSeminiferousTubule5.3
Thalamus6.5
Thymus4.75
Thyroid7.55
Tongue10.45
Tonsil6.5
Trachea581.05
TrigeminalGanglion7.3
Uterus4.9
UterusCorpus7.5
WholeBlood6.75
Wholebrain5.05
colon6.3
pineal_day7.66
pineal_night7.52
retina7.55
small_intestine6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P502413
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.14 ± 0.99
Basal Forebrain1.68 ± 0.2
Basal Part of Pons1.39 ± 0.37
Cerebellar Cortex1.65 ± 0.84
Cerebellar Nuclei2.13 ± 0.94
Claustrum2.59 ± 0.84
Epithalamus1.67 ± 0.58
Frontal Lobe1.57 ± 0.61
Globus Pallidus2.31 ± 0.38
Hypothalamus1.81 ± 0.66
Insula1.99 ± 1.26
Limbic Lobe1.75 ± 0.64
Mesencephalon1.92 ± 0.68
Myelencephalon1.77 ± 0.69
Occipital Lobe1.83 ± 0.6
Parietal Lobe1.77 ± 0.68
Pontine Tegmentum1.82 ± 0.66
Striatum1.96 ± 0.7
Subthalamus1.93 ± 0.73
Temporal Lobe1.61 ± 0.59
Thalamus1.75 ± 0.64
White Matter2.37 ± 0.37
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00075444 23 161 183 NLFPDGTIGNDTTLVLVNAIYFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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