AutismKB 2.0

Annotation Detail for SCN2B


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Basic Information Top
Gene Symbol:SCN2B ( - )
Gene Full Name: sodium channel, voltage-gated, type II, beta
Band: 11q23.3
Quick LinksEntrez ID:6327; OMIM: 601327; Uniprot ID:SCN2B_HUMAN; ENSEMBL ID: ENSG00000149575; HGNC ID: 10589
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant4 / 23620169
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal49 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye6 / 21105428
heart3 / 8962633
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210363_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.7
Adipocyte6.45
AdrenalCortex7.25
Adrenalgland5.7
Amygdala19.75
Appendix7.5
AtrioventricularNode4.95
BDCA4+_DentriticCells6.4
Bonemarrow6.5
BronchialEpithelialCells6.4
CD105+_Endothelial6.6
CD14+_Monocytes7.1
CD19+_BCells(neg._sel.)6.85
CD33+_Myeloid8.25
CD34+8.05
CD4+_Tcells6.75
CD56+_NKCells7.6
CD71+_EarlyErythroid6.15
CD8+_Tcells5.85
CardiacMyocytes9.65
Caudatenucleus6.05
Cerebellum38.25
CerebellumPeduncles27.8
CiliaryGanglion4.6
CingulateCortex6.75
Colorectaladenocarcinoma6.65
DorsalRootGanglion5
FetalThyroid6.45
Fetalbrain6.45
Fetalliver5.9
Fetallung5.35
GlobusPallidus5.1
Heart9.95
Hypothalamus7.35
Kidney7.45
Leukemia_chronicMyelogenousK-5625.95
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)5.35
Liver9
Lung7.3
Lymphnode5.6
Lymphoma_burkitts(Daudi)8.7
Lymphoma_burkitts(Raji)9.85
MedullaOblongata7.6
OccipitalLobe5.95
OlfactoryBulb5.2
Ovary4.55
Pancreas5.25
PancreaticIslet7.15
ParietalLobe7.55
Pituitary7.8
Placenta6.9
Pons6.55
PrefrontalCortex8.75
Prostate7.8
Salivarygland5.4
SkeletalMuscle26.9
Skin5
SmoothMuscle7.5
Spinalcord7.05
SubthalamicNucleus6.15
SuperiorCervicalGanglion8.05
TemporalLobe7.4
Testis5.7
TestisGermCell5.5
TestisIntersitial5.45
TestisLeydigCell6.5
TestisSeminiferousTubule5.6
Thalamus6.7
Thymus5.25
Thyroid8
Tongue6.65
Tonsil6.5
Trachea6.25
TrigeminalGanglion6.5
Uterus5.45
UterusCorpus6.3
WholeBlood7.25
Wholebrain39.1
colon6.7
pineal_day8.06
pineal_night7.88
retina8.05
small_intestine6.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P306819
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.51 ± 0.44
Basal Forebrain6.29 ± 0.42
Basal Part of Pons6.89 ± 0.61
Cerebellar Cortex6.99 ± 0.48
Cerebellar Nuclei5.16 ± 0.71
Claustrum6.39 ± 0.55
Epithalamus5.57 ± 0.54
Frontal Lobe6.77 ± 0.59
Globus Pallidus5.05 ± 0.59
Hypothalamus6.08 ± 0.65
Insula6.78 ± 0.35
Limbic Lobe6.56 ± 0.63
Mesencephalon6.25 ± 0.71
Myelencephalon6.45 ± 0.67
Occipital Lobe5.88 ± 0.79
Parietal Lobe6.51 ± 0.55
Pontine Tegmentum6.15 ± 0.68
Striatum5.85 ± 0.57
Subthalamus6.36 ± 0.75
Temporal Lobe6.69 ± 0.52
Thalamus6.72 ± 0.42
White Matter4.09 ± 0.3
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00073722 14 48 61 LPCTFNSCYTVNHK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018