AutismKB 2.0

Annotation Detail for SCN4B


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Basic Information Top
Gene Symbol:SCN4B ( - )
Gene Full Name: sodium channel, voltage-gated, type IV, beta
Band: 11q23.3
Quick LinksEntrez ID:6330; OMIM: 608256; Uniprot ID:SCN4B_HUMAN; ENSEMBL ID: ENSG00000177098; HGNC ID: 10592
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult21 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal111 / 336030733
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain101 / 110098991
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth3 / 6705244
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12575_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.73 ± 0.74
Basal Forebrain3.62 ± 0.48
Basal Part of Pons5.47 ± 0.69
Cerebellar Cortex4.06 ± 0.27
Cerebellar Nuclei6.05 ± 0.54
Claustrum5.1 ± 0.86
Epithalamus3.97 ± 0.71
Frontal Lobe4.29 ± 0.97
Globus Pallidus3.99 ± 0.87
Hypothalamus3.12 ± 1.02
Insula3.79 ± 0.56
Limbic Lobe4.38 ± 0.69
Mesencephalon4.18 ± 0.92
Myelencephalon4.4 ± 1.04
Occipital Lobe5.17 ± 0.84
Parietal Lobe4.67 ± 0.71
Pontine Tegmentum4.67 ± 1.1
Striatum6.88 ± 0.85
Subthalamus3.49 ± 0.57
Temporal Lobe3.95 ± 0.59
Thalamus4.27 ± 1.06
White Matter1.79 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Scn4bCBCerebellum0
0
Scn4bCTXCerebral cortex0
0
Scn4bHIPHippocampal region0
0
Scn4bHPFHippocampal formation0
0
Scn4bHYHypothalamus0
0
Scn4bLSXLateral septal complex0
0
Scn4bMBMidbrain0
0
Scn4bMYMedulla0
0
Scn4bOLFOlfactory bulb0
0
Scn4bPPons0
0
Scn4bPALPallidum0
0
Scn4bRHPRetrohippocampal region0
0
Scn4bsAMYStriatum-like amygdalar nuclei0
0
Scn4bSTRStriatum0
0
Scn4bSTRdStriatum dorsal region0
0
Scn4bSTRvStriatum ventral region0
0
Scn4bTHThalamus0
0
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018