AutismKB 2.0

Annotation Detail for CCL2


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Basic Information Top
Gene Symbol:CCL2 ( GDCF-2,HC11,HSMCR30,MCAF,MCP-1,MCP1,MGC9434,SCYA2,SMC-CF )
Gene Full Name: chemokine (C-C motif) ligand 2
Band: 17q12
Quick LinksEntrez ID:6347; OMIM: 158105; Uniprot ID:CCL2_HUMAN; ENSEMBL ID: ENSG00000108691; HGNC ID: 10618
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus21 / 56401237
neonate2 / 3109764
infant1 / 2362042
juvenile0 / 555560 
adult106 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor6 / 12794468
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma13 / 82823156
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma9 / 10688384
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal186 / 336030755
ovarian tumor0 / 766820 
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland8 / 33197240
ascites0 / 400150 
bladder1 / 2975733
blood23 / 123478186
bone5 / 7165569
bone marrow1 / 4880120
brain14 / 110098912
cervix0 / 481710 
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye14 / 21105466
heart4 / 8962644
intestine11 / 23447246
kidney14 / 21177766
larynx1 / 2414541
liver7 / 20774333
lung25 / 33697474
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas29 / 214812135
parathyroid1 / 2053948
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta12 / 28082542
prostate2 / 18934510
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach1 / 9661910
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216598_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6
Adipocyte22.1
AdrenalCortex58.1
Adrenalgland57.4
Amygdala15.2
Appendix51.85
AtrioventricularNode13.1
BDCA4+_DentriticCells3.9
Bonemarrow17.3
BronchialEpithelialCells12.75
CD105+_Endothelial4.75
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)3.55
CD33+_Myeloid12.4
CD34+8.95
CD4+_Tcells3.75
CD56+_NKCells4.7
CD71+_EarlyErythroid4.25
CD8+_Tcells3
CardiacMyocytes2303.9
Caudatenucleus13.65
Cerebellum13.45
CerebellumPeduncles17.9
CiliaryGanglion54.35
CingulateCortex17.65
Colorectaladenocarcinoma13.05
DorsalRootGanglion14.95
FetalThyroid20.95
Fetalbrain56.15
Fetalliver15.5
Fetallung513.6
GlobusPallidus12.8
Heart25.35
Hypothalamus26.95
Kidney27.4
Leukemia_chronicMyelogenousK-56211.15
Leukemia_promyelocytic-HL-6010.95
Leukemialymphoblastic(MOLT-4)9.65
Liver19.6
Lung22.1
Lymphnode46.75
Lymphoma_burkitts(Daudi)19.15
Lymphoma_burkitts(Raji)20.2
MedullaOblongata15.25
OccipitalLobe14.8
OlfactoryBulb29.8
Ovary10.2
Pancreas15.2
PancreaticIslet181.3
ParietalLobe20.3
Pituitary42.15
Placenta18.75
Pons124.1
PrefrontalCortex16.15
Prostate20.25
Salivarygland14.4
SkeletalMuscle25.1
Skin18.6
SmoothMuscle7800.85
Spinalcord74.75
SubthalamicNucleus18.2
SuperiorCervicalGanglion36.1
TemporalLobe18.3
Testis12.9
TestisGermCell13.7
TestisIntersitial14.1
TestisLeydigCell14.75
TestisSeminiferousTubule13
Thalamus15.35
Thymus33.55
Thyroid19.3
Tongue19.6
Tonsil22
Trachea58.55
TrigeminalGanglion70
Uterus11.7
UterusCorpus17.65
WholeBlood14.95
Wholebrain11.55
colon18.15
pineal_day16.42
pineal_night14.72
retina91.8
small_intestine72.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16893_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3 ± 0.97
Basal Forebrain2.43 ± 0.57
Basal Part of Pons2.62 ± 0.61
Cerebellar Cortex2.24 ± 0.63
Cerebellar Nuclei2.84 ± 0.62
Claustrum3.41 ± 0.98
Epithalamus4.48 ± 0.59
Frontal Lobe2.55 ± 0.92
Globus Pallidus4.66 ± 0.32
Hypothalamus3.15 ± 1.4
Insula2.41 ± 0.67
Limbic Lobe2.61 ± 1
Mesencephalon2.75 ± 0.76
Myelencephalon2.78 ± 0.76
Occipital Lobe2.93 ± 1.19
Parietal Lobe2.52 ± 0.78
Pontine Tegmentum2.75 ± 1.18
Striatum2.95 ± 0.88
Subthalamus2.43 ± 0.45
Temporal Lobe2.54 ± 0.94
Thalamus2.86 ± 0.7
White Matter4.45 ± 0.86
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ccl2CBCerebellum18.6
26.45
Ccl2CTXCerebral cortex12.31
10.97
Ccl2HIPHippocampal region12.27
14.95
Ccl2HPFHippocampal formation10
10.48
Ccl2HYHypothalamus1.32
1.35
Ccl2LSXLateral septal complex0.13
0.2
Ccl2MBMidbrain2.3
2.79
Ccl2MYMedulla6.17
7
Ccl2OLFOlfactory bulb10.48
9.1
Ccl2PPons3.25
3.53
Ccl2PALPallidum1.83
1.4
Ccl2RHPRetrohippocampal region7
5.38
Ccl2sAMYStriatum-like amygdalar nuclei4.13
2.77
Ccl2STRStriatum4.12
3.05
Ccl2STRdStriatum dorsal region4.25
3.28
Ccl2STRvStriatum ventral region5.4
3.55
Ccl2THThalamus3.53
3.83
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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