AutismKB 2.0

Annotation Detail for BIK


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Basic Information Top
Gene Symbol:BIK ( BIP1,BP4,NBK )
Gene Full Name: BCL2-interacting killer (apoptosis-inducing)
Band: 22q13.2
Quick LinksEntrez ID:638; OMIM: 603392; Uniprot ID:BIK_HUMAN; ENSEMBL ID: ENSG00000100290; HGNC ID: 1051
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal26 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine9 / 23447238
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung2 / 3369745
lymph6 / 44270135
lymph node8 / 9161087
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach3 / 9661931
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205780_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.4
Adipocyte3.5
AdrenalCortex3.65
Adrenalgland3.3
Amygdala5.6
Appendix3.65
AtrioventricularNode2.7
BDCA4+_DentriticCells54.8
Bonemarrow4.1
BronchialEpithelialCells18.6
CD105+_Endothelial3.55
CD14+_Monocytes3.75
CD19+_BCells(neg._sel.)3.85
CD33+_Myeloid4.5
CD34+5.15
CD4+_Tcells3.85
CD56+_NKCells4.2
CD71+_EarlyErythroid3.3
CD8+_Tcells3.5
CardiacMyocytes4.45
Caudatenucleus3.15
Cerebellum2.8
CerebellumPeduncles4
CiliaryGanglion2.45
CingulateCortex3.6
Colorectaladenocarcinoma50.4
DorsalRootGanglion2.65
FetalThyroid3.4
Fetalbrain3.5
Fetalliver3.05
Fetallung3.1
GlobusPallidus2.6
Heart6.85
Hypothalamus3.8
Kidney2.8
Leukemia_chronicMyelogenousK-5623.15
Leukemia_promyelocytic-HL-6052.2
Leukemialymphoblastic(MOLT-4)2.8
Liver4.65
Lung6.3
Lymphnode3.05
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)35.75
MedullaOblongata3.25
OccipitalLobe3.15
OlfactoryBulb2.75
Ovary2.5
Pancreas2.8
PancreaticIslet3.8
ParietalLobe3.65
Pituitary4.15
Placenta3.6
Pons3.3
PrefrontalCortex4.35
Prostate52.8
Salivarygland2.8
SkeletalMuscle4
Skin2.65
SmoothMuscle4
Spinalcord4.65
SubthalamicNucleus3.2
SuperiorCervicalGanglion4.7
TemporalLobe3.2
Testis3.6
TestisGermCell2.9
TestisIntersitial2.95
TestisLeydigCell3.45
TestisSeminiferousTubule3
Thalamus3.55
Thymus2.8
Thyroid5.35
Tongue3.4
Tonsil6.3
Trachea12.75
TrigeminalGanglion3.45
Uterus2.9
UterusCorpus3.15
WholeBlood4.9
Wholebrain2.95
colon45.35
pineal_day4.42
pineal_night4.3
retina4.25
small_intestine6.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P404667
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.93 ± 0.98
Basal Forebrain1.68 ± 0.19
Basal Part of Pons1.24 ± 0.29
Cerebellar Cortex1.33 ± 0.68
Cerebellar Nuclei1.77 ± 0.72
Claustrum2.34 ± 0.81
Epithalamus1.27 ± 0.73
Frontal Lobe1.37 ± 0.6
Globus Pallidus2.12 ± 0.35
Hypothalamus1.67 ± 0.74
Insula1.42 ± 0.5
Limbic Lobe1.52 ± 0.6
Mesencephalon1.67 ± 0.63
Myelencephalon1.52 ± 0.64
Occipital Lobe1.61 ± 0.73
Parietal Lobe1.44 ± 0.56
Pontine Tegmentum1.54 ± 0.66
Striatum1.71 ± 0.51
Subthalamus1.63 ± 0.59
Temporal Lobe1.41 ± 0.64
Thalamus1.48 ± 0.56
White Matter2.1 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
BikCBCerebellum0.63
2.38
BikCTXCerebral cortex0.24
0.35
BikHIPHippocampal region1.01
1.1
BikHPFHippocampal formation0.72
0.73
BikHYHypothalamus0.31
0.38
BikLSXLateral septal complex0.17
0.14
BikMBMidbrain0.18
0.45
BikMYMedulla0.34
0.87
BikOLFOlfactory bulb1.45
2.32
BikPPons0.97
3.28
BikPALPallidum0.52
0.48
BikRHPRetrohippocampal region0.08
0.05
BiksAMYStriatum-like amygdalar nuclei0.68
0.67
BikSTRStriatum0.31
0.28
BikSTRdStriatum dorsal region0.1
0.09
BikSTRvStriatum ventral region0.96
0.77
BikTHThalamus0.05
0.06
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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