AutismKB 2.0

Annotation Detail for CXCL12


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Basic Information Top
Gene Symbol:CXCL12 ( IRH,PBSF,SCYB12,SDF1,SDF1A,SDF1B,TLSF,TPAR1 )
Gene Full Name: chemokine (C-X-C motif) ligand 12
Band: 10q11.21
Quick LinksEntrez ID:6387; OMIM: 600835; Uniprot ID:SDF1_HUMAN; ENSEMBL ID: ENSG00000107562; HGNC ID: 10672
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst6 / 6231996
fetus90 / 564012159
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult132 / 193912168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor11 / 26384541
glioma0 / 1068830 
head and neck tumor8 / 13630258
kidney tumor6 / 6895987
leukemia1 / 9584210
liver tumor6 / 9635962
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia16 / 97250164
normal305 / 336030790
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone23 / 71655320
bone marrow1 / 4880120
brain47 / 110098942
cervix2 / 4817141
connective tissue20 / 149255133
ear2 / 16212123
embryonic tissue27 / 215722125
esophagus0 / 202090 
eye12 / 21105456
heart25 / 89626278
intestine9 / 23447238
kidney22 / 211777103
larynx0 / 241450 
liver13 / 20774362
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland16 / 153271104
mouth3 / 6705244
muscle3 / 10771527
nerve6 / 15768380
ovary1 / 1020519
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate2 / 18934510
salivary gland5 / 20155248
skin8 / 21057437
spleen16 / 53952296
stomach4 / 9661941
testis10 / 33044230
thymus5 / 8113161
thyroid0 / 474730 
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus23 / 23287898
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203666_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.65
Adipocyte6.85
AdrenalCortex10.15
Adrenalgland5
Amygdala6.1
Appendix26.35
AtrioventricularNode5.85
BDCA4+_DentriticCells6
Bonemarrow115.65
BronchialEpithelialCells5.65
CD105+_Endothelial2912.2
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5
CD33+_Myeloid7
CD34+7.5
CD4+_Tcells4.45
CD56+_NKCells6.55
CD71+_EarlyErythroid5.3
CD8+_Tcells4.45
CardiacMyocytes33.5
Caudatenucleus5.2
Cerebellum4.65
CerebellumPeduncles6.5
CiliaryGanglion4.25
CingulateCortex5.9
Colorectaladenocarcinoma5.75
DorsalRootGanglion4.5
FetalThyroid12.35
Fetalbrain5.9
Fetalliver17.4
Fetallung5.35
GlobusPallidus4.1
Heart7.35
Hypothalamus6.35
Kidney9.95
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)4.45
Liver8.9
Lung6.4
Lymphnode50.75
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)7.85
MedullaOblongata5.35
OccipitalLobe5.1
OlfactoryBulb8.2
Ovary4.85
Pancreas6
PancreaticIslet6.3
ParietalLobe6
Pituitary7.45
Placenta5.8
Pons5.5
PrefrontalCortex6.8
Prostate6.55
Salivarygland17.45
SkeletalMuscle14.2
Skin7.9
SmoothMuscle6.65
Spinalcord8.85
SubthalamicNucleus5.1
SuperiorCervicalGanglion15
TemporalLobe5.3
Testis5
TestisGermCell4.65
TestisIntersitial4.75
TestisLeydigCell5.7
TestisSeminiferousTubule4.8
Thalamus5.75
Thymus6.35
Thyroid7.35
Tongue6.6
Tonsil5.6
Trachea5.1
TrigeminalGanglion9.5
Uterus9.55
UterusCorpus27.55
WholeBlood6.2
Wholebrain4.25
colon5.85
pineal_day7.2
pineal_night6.6
retina7.425
small_intestine20.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16809_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.64 ± 0.55
Basal Forebrain7.4 ± 0.18
Basal Part of Pons6.71 ± 0.24
Cerebellar Cortex7.04 ± 0.27
Cerebellar Nuclei8.77 ± 0.38
Claustrum7.11 ± 0.56
Epithalamus8.28 ± 0.55
Frontal Lobe7.51 ± 0.52
Globus Pallidus8.76 ± 0.31
Hypothalamus7.26 ± 0.35
Insula7.48 ± 0.44
Limbic Lobe7.54 ± 0.58
Mesencephalon7.79 ± 0.39
Myelencephalon7.62 ± 0.58
Occipital Lobe7.75 ± 0.73
Parietal Lobe7.54 ± 0.49
Pontine Tegmentum7.75 ± 0.53
Striatum8.31 ± 0.46
Subthalamus7.65 ± 0.3
Temporal Lobe7.31 ± 0.45
Thalamus7.47 ± 0.35
White Matter7.29 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cxcl12CBCerebellum3.26
3.9
Cxcl12CTXCerebral cortex4.44
4.04
Cxcl12HIPHippocampal region15.43
10.2
Cxcl12HPFHippocampal formation10.88
7.05
Cxcl12HYHypothalamus0.72
0.71
Cxcl12LSXLateral septal complex2.25
2.05
Cxcl12MBMidbrain1.73
2.08
Cxcl12MYMedulla2.34
2.67
Cxcl12OLFOlfactory bulb3.05
2.55
Cxcl12PPons2.37
2.48
Cxcl12PALPallidum0.84
1.13
Cxcl12RHPRetrohippocampal region3.86
3.04
Cxcl12sAMYStriatum-like amygdalar nuclei3.48
3.16
Cxcl12STRStriatum1.75
1.69
Cxcl12STRdStriatum dorsal region1.33
1.33
Cxcl12STRvStriatum ventral region1.22
1.03
Cxcl12THThalamus2.87
2.55
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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