AutismKB 2.0

Annotation Detail for SDHA


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Basic Information Top
Gene Symbol:SDHA ( FP,SDH1,SDH2,SDHF )
Gene Full Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Band: 5p15.33
Quick LinksEntrez ID:6389; OMIM: 600857; Uniprot ID:DHSA_HUMAN; ENSEMBL ID: ENSG00000073578; HGNC ID: 10680
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst9 / 62319144
fetus63 / 564012111
neonate8 / 31097257
infant3 / 23620127
juvenile36 / 55556647
adult268 / 1939121138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor19 / 94178201
cervical tumor6 / 34366174
chondrosarcoma8 / 8282396
colorectal tumor35 / 114246306
esophageal tumor4 / 17290231
gastrointestinal tumor42 / 119369351
germ cell tumor65 / 263845246
glioma20 / 106883187
head and neck tumor47 / 136302344
kidney tumor27 / 68959391
leukemia20 / 95842208
liver tumor13 / 96359134
lung tumor29 / 103127281
lymphoma19 / 71755264
non-neoplasia25 / 97250257
normal625 / 3360307185
ovarian tumor2 / 7668226
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS56 / 125680445
prostate cancer14 / 102680136
retinoblastoma13 / 46356280
skin tumor26 / 124949208
soft tissue/muscle tissue tumor34 / 125191271
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland14 / 33197421
ascites18 / 40015449
bladder9 / 29757302
blood25 / 123478202
bone4 / 7165555
bone marrow13 / 48801266
brain368 / 1100989334
cervix8 / 48171166
connective tissue34 / 149255227
ear1 / 1621261
embryonic tissue14 / 21572264
esophagus4 / 20209197
eye25 / 211054118
heart52 / 89626580
intestine76 / 234472324
kidney68 / 211777321
larynx6 / 24145248
liver33 / 207743158
lung49 / 336974145
lymph4 / 4427090
lymph node8 / 9161087
mammary gland23 / 153271150
mouth31 / 67052462
muscle18 / 107715167
nerve2 / 15768126
ovary9 / 10205188
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta46 / 280825163
prostate19 / 189345100
salivary gland3 / 20155148
skin46 / 210574218
spleen14 / 53952259
stomach21 / 96619217
testis70 / 330442211
thymus22 / 81131271
thyroid19 / 47473400
tonsil2 / 16999117
trachea6 / 52413114
umbilical cord3 / 13680219
uterus47 / 232878201
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222021_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts454.9
Adipocyte251.85
AdrenalCortex202.1
Adrenalgland269.1
Amygdala248.15
Appendix74.9
AtrioventricularNode14.6
BDCA4+_DentriticCells376.5
Bonemarrow85.85
BronchialEpithelialCells272
CD105+_Endothelial395.15
CD14+_Monocytes283.2
CD19+_BCells(neg._sel.)337.75
CD33+_Myeloid316.25
CD34+536.85
CD4+_Tcells397.3
CD56+_NKCells431.9
CD71+_EarlyErythroid320.8
CD8+_Tcells383.8
CardiacMyocytes162.5
Caudatenucleus152.85
Cerebellum279.9
CerebellumPeduncles316.5
CiliaryGanglion37.65
CingulateCortex275.65
Colorectaladenocarcinoma274.5
DorsalRootGanglion39.8
FetalThyroid177.55
Fetalbrain131.2
Fetalliver139.75
Fetallung178.1
GlobusPallidus180.25
Heart962.1
Hypothalamus364.8
Kidney286.8
Leukemia_chronicMyelogenousK-562286.6
Leukemia_promyelocytic-HL-60284.8
Leukemialymphoblastic(MOLT-4)229.6
Liver559.7
Lung284.65
Lymphnode182.8
Lymphoma_burkitts(Daudi)373.8
Lymphoma_burkitts(Raji)546.8
MedullaOblongata178.9
OccipitalLobe250.45
OlfactoryBulb133.35
Ovary98.55
Pancreas80
PancreaticIslet174.7
ParietalLobe227.55
Pituitary212.1
Placenta174.7
Pons124.6
PrefrontalCortex276.35
Prostate232.3
Salivarygland149.15
SkeletalMuscle324.95
Skin19.35
SmoothMuscle195.2
Spinalcord181.9
SubthalamicNucleus158.65
SuperiorCervicalGanglion18
TemporalLobe149.8
Testis341.7
TestisGermCell203.35
TestisIntersitial150.65
TestisLeydigCell199.5
TestisSeminiferousTubule147.5
Thalamus381.95
Thymus227.5
Thyroid255.25
Tongue263.25
Tonsil151.6
Trachea96.25
TrigeminalGanglion62.45
Uterus206.85
UterusCorpus99.7
WholeBlood120.05
Wholebrain411.65
colon494
pineal_day224.7
pineal_night188.9
retina311.05
small_intestine618.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2871_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.21 ± 0.34
Basal Forebrain8.37 ± 0.09
Basal Part of Pons8.55 ± 0.24
Cerebellar Cortex8.59 ± 0.18
Cerebellar Nuclei8.62 ± 0.23
Claustrum8.55 ± 0.38
Epithalamus8.23 ± 0.31
Frontal Lobe8.17 ± 0.32
Globus Pallidus8.46 ± 0.4
Hypothalamus8.2 ± 0.34
Insula8.01 ± 0.33
Limbic Lobe8.15 ± 0.32
Mesencephalon8.22 ± 0.34
Myelencephalon8.2 ± 0.37
Occipital Lobe8.35 ± 0.31
Parietal Lobe8.38 ± 0.32
Pontine Tegmentum8.25 ± 0.35
Striatum8.08 ± 0.38
Subthalamus8.17 ± 0.54
Temporal Lobe8.21 ± 0.27
Thalamus8.23 ± 0.36
White Matter9.1 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SdhaCBCerebellum99.51
100
SdhaCTXCerebral cortex100
100
SdhaHIPHippocampal region100
100
SdhaHPFHippocampal formation100
100
SdhaHYHypothalamus100
100
SdhaLSXLateral septal complex100
100
SdhaMBMidbrain100
100
SdhaMYMedulla100
100
SdhaOLFOlfactory bulb100
100
SdhaPPons100
100
SdhaPALPallidum100
100
SdhaRHPRetrohippocampal region100
100
SdhasAMYStriatum-like amygdalar nuclei100
100
SdhaSTRStriatum100
100
SdhaSTRdStriatum dorsal region100
100
SdhaSTRvStriatum ventral region100
100
SdhaTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DHSA_HUMAN_196 12 196 207 TGHSLLHTLYGR PRIDE
DHSA_HUMAN_232 14 232 245 GVIALCIEDGSIHR PRIDE
DHSA_HUMAN_251 11 251 261 NTVVATGGYGR PRIDE
DHSA_HUMAN_312 13 312 324 GEGGILINSQGER PRIDE
DHSA_HUMAN_313 13 313 325 GEGGILINSQGER PRIDE
DHSA_HUMAN_451 14 451 464 LGANSLLDLVVFGR PRIDE
DHSA_HUMAN_452 14 452 465 LGANSLLDLVVFGR PRIDE
DHSA_HUMAN_481 18 481 498 VPPIKPNAGEESVMNLDK PRIDE
DHSA_HUMAN_600 15 600 614 IDEYDYSKPIQGQQK PRIDE
DHSA_HUMAN_637 11 637 647 VTLEYRPVIDK PRIDE
DHSA_HUMAN_76 17 76 92 AAFGLSEAGFNTACVTK PRIDE
PAp00000149 17 76 92 AAFGLSEAGFNTACVTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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