AutismKB 2.0

Annotation Detail for SDHB


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Basic Information Top
Gene Symbol:SDHB ( FLJ92337,IP,PGL4,SDH,SDH1,SDH2,SDHIP )
Gene Full Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Band: 1p36.13
Quick LinksEntrez ID:6390; OMIM: 185470; Uniprot ID:DHSB_HUMAN; ENSEMBL ID: ENSG00000117118; HGNC ID: 10681
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus31 / 56401254
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult154 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor7 / 9417874
cervical tumor3 / 3436687
chondrosarcoma10 / 82823120
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor10 / 26384537
glioma1 / 1068839
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor11 / 96359114
lung tumor16 / 103127155
lymphoma6 / 7175583
non-neoplasia4 / 9725041
normal200 / 336030759
ovarian tumor7 / 7668291
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor17 / 124949136
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites4 / 4001599
bladder0 / 297570 
blood9 / 12347872
bone7 / 7165597
bone marrow3 / 4880161
brain49 / 110098944
cervix6 / 48171124
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye15 / 21105471
heart10 / 89626111
intestine13 / 23447255
kidney7 / 21177733
larynx2 / 2414582
liver26 / 207743125
lung40 / 336974118
lymph4 / 4427090
lymph node0 / 916100 
mammary gland14 / 15327191
mouth1 / 6705214
muscle13 / 107715120
nerve0 / 157680 
ovary9 / 10205188
pancreas23 / 214812107
parathyroid7 / 20539340
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta20 / 28082571
prostate11 / 18934558
salivary gland2 / 2015599
skin29 / 210574137
spleen0 / 539520 
stomach2 / 9661920
testis12 / 33044236
thymus0 / 811310 
thyroid4 / 4747384
tonsil7 / 16999411
trachea0 / 524130 
umbilical cord0 / 136800 
uterus21 / 23287890
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202675_at
Cell line Expression level Expression bar
721_B_lymphoblasts1020.1
Adipocyte184.15
AdrenalCortex75.6
Adrenalgland101.35
Amygdala236.25
Appendix36.65
AtrioventricularNode49.3
BDCA4+_DentriticCells272.15
Bonemarrow86.3
BronchialEpithelialCells499.5
CD105+_Endothelial270.55
CD14+_Monocytes556.05
CD19+_BCells(neg._sel.)185.25
CD33+_Myeloid449.75
CD34+220.65
CD4+_Tcells131.95
CD56+_NKCells240.05
CD71+_EarlyErythroid154.9
CD8+_Tcells91.95
CardiacMyocytes148.7
Caudatenucleus97.65
Cerebellum89.35
CerebellumPeduncles128.9
CiliaryGanglion45.2
CingulateCortex97.95
Colorectaladenocarcinoma215.4
DorsalRootGanglion54.85
FetalThyroid59.25
Fetalbrain68.2
Fetalliver79.95
Fetallung108.8
GlobusPallidus92.15
Heart730.8
Hypothalamus171.25
Kidney200.3
Leukemia_chronicMyelogenousK-562251.2
Leukemia_promyelocytic-HL-60707.05
Leukemialymphoblastic(MOLT-4)136.6
Liver242.3
Lung164.05
Lymphnode62.7
Lymphoma_burkitts(Daudi)321.7
Lymphoma_burkitts(Raji)902.75
MedullaOblongata75.65
OccipitalLobe106.1
OlfactoryBulb76.3
Ovary36.8
Pancreas70.15
PancreaticIslet134.45
ParietalLobe119.15
Pituitary90.65
Placenta142.35
Pons70.35
PrefrontalCortex139.15
Prostate121.5
Salivarygland114.15
SkeletalMuscle94.7
Skin58.9
SmoothMuscle195
Spinalcord108.45
SubthalamicNucleus60.65
SuperiorCervicalGanglion74
TemporalLobe85.9
Testis172.55
TestisGermCell148.55
TestisIntersitial205.7
TestisLeydigCell120
TestisSeminiferousTubule81.95
Thalamus134.5
Thymus116.85
Thyroid238.7
Tongue102
Tonsil108.85
Trachea79.2
TrigeminalGanglion72.4
Uterus83.6
UterusCorpus57
WholeBlood233.05
Wholebrain300.9
colon499.6
pineal_day153.9
pineal_night150.76
retina210.2
small_intestine489.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16509_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.3 ± 0.16
Basal Forebrain7.05 ± 0.19
Basal Part of Pons7.62 ± 0.22
Cerebellar Cortex7.46 ± 0.27
Cerebellar Nuclei7.64 ± 0.41
Claustrum6.85 ± 0.35
Epithalamus7.16 ± 0.09
Frontal Lobe7.43 ± 0.32
Globus Pallidus7.14 ± 0.27
Hypothalamus7.2 ± 0.32
Insula7.35 ± 0.2
Limbic Lobe7.16 ± 0.41
Mesencephalon7.2 ± 0.34
Myelencephalon7.23 ± 0.37
Occipital Lobe7.01 ± 0.33
Parietal Lobe7.35 ± 0.3
Pontine Tegmentum7.32 ± 0.27
Striatum6.99 ± 0.28
Subthalamus7.58 ± 0.12
Temporal Lobe7.34 ± 0.3
Thalamus7.38 ± 0.28
White Matter7.28 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SdhbCBCerebellum58.53
100
SdhbCTXCerebral cortex100
100
SdhbHIPHippocampal region100
100
SdhbHPFHippocampal formation100
100
SdhbHYHypothalamus100
100
SdhbLSXLateral septal complex100
100
SdhbMBMidbrain100
100
SdhbMYMedulla100
100
SdhbOLFOlfactory bulb100
100
SdhbPPons98.43
100
SdhbPALPallidum100
100
SdhbRHPRetrohippocampal region100
100
SdhbsAMYStriatum-like amygdalar nuclei100
100
SdhbSTRStriatum100
100
SdhbSTRdStriatum dorsal region100
100
SdhbSTRvStriatum ventral region100
100
SdhbTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DHSB_HUMAN_0 0 0 0 LQDPFSLYR PRIDE
DHSB_HUMAN_126 25 126 150 IYPLPHMYVIKDLVPDLSNFYAQYK PRIDE
DHSB_HUMAN_137 14 137 150 DLVPDLSNFYAQYK PRIDE
DHSB_HUMAN_167 10 167 176 QQYLQSIEER PRIDE
DHSB_HUMAN_168 10 168 177 QQYLQSIEER PRIDE
DHSB_HUMAN_205 12 205 216 YLGPAVLMQAYR PRIDE
DHSB_HUMAN_233 9 233 241 LQDPFSLYR PRIDE
DHSB_HUMAN_29 10 29 38 AQTAAATAPR PRIDE
DHSB_HUMAN_46 21 46 66 WDPDKAGDKPHMQTYEVDLNK PRIDE
DHSB_HUMAN_67 11 67 77 CGPMVLDALIK PRIDE
PAp00001026 11 68 78 CGPMVLDALIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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