AutismKB 2.0

Annotation Detail for ZNF335


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Basic Information Top
Gene Symbol:ZNF335 ( NIF-1,NIF1,NIF2 )
Gene Full Name: zinc finger protein 335
Band: 20q13.12
Quick LinksEntrez ID:63925; OMIM: 610827; Uniprot ID:ZN335_HUMAN; ENSEMBL ID: ENSG00000198026; HGNC ID: 15807
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia7 / 9584273
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal86 / 336030725
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood4 / 12347832
bone0 / 716550 
bone marrow1 / 4880120
brain25 / 110098922
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine11 / 23447246
kidney4 / 21177718
larynx1 / 2414541
liver2 / 2077439
lung2 / 3369745
lymph1 / 4427022
lymph node7 / 9161076
mammary gland7 / 15327145
mouth4 / 6705259
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta4 / 28082514
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen5 / 5395292
stomach1 / 9661910
testis10 / 33044230
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221890_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.4
Adipocyte3.85
AdrenalCortex4.2
Adrenalgland3.3
Amygdala4.15
Appendix4
AtrioventricularNode3.1
BDCA4+_DentriticCells7.85
Bonemarrow3.95
BronchialEpithelialCells3.85
CD105+_Endothelial3.95
CD14+_Monocytes4.25
CD19+_BCells(neg._sel.)4.25
CD33+_Myeloid5.05
CD34+5.05
CD4+_Tcells20.65
CD56+_NKCells9.3
CD71+_EarlyErythroid3.7
CD8+_Tcells17.55
CardiacMyocytes4.85
Caudatenucleus3.55
Cerebellum3.25
CerebellumPeduncles4.5
CiliaryGanglion2.85
CingulateCortex4.1
Colorectaladenocarcinoma4.1
DorsalRootGanglion3.15
FetalThyroid3.95
Fetalbrain4.05
Fetalliver3.5
Fetallung3.25
GlobusPallidus3
Heart5.1
Hypothalamus4.25
Kidney3.25
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.2
Liver5.3
Lung4.9
Lymphnode4.35
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)7.35
MedullaOblongata3.6
OccipitalLobe3.55
OlfactoryBulb3.1
Ovary2.9
Pancreas3.2
PancreaticIslet4.2
ParietalLobe4.3
Pituitary4.8
Placenta4.1
Pons3.8
PrefrontalCortex4.95
Prostate4.7
Salivarygland3.15
SkeletalMuscle4.65
Skin3.3
SmoothMuscle4.45
Spinalcord4.25
SubthalamicNucleus3.7
SuperiorCervicalGanglion4.6
TemporalLobe3.65
Testis3.4
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.4
Thalamus4.05
Thymus4.15
Thyroid4.9
Tongue3.95
Tonsil4.6
Trachea3.3
TrigeminalGanglion4.05
Uterus3.25
UterusCorpus3.6
WholeBlood4.3
Wholebrain3.35
colon3.95
pineal_day4.94
pineal_night4.88
retina4.8
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14943_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.39 ± 0.36
Basal Forebrain5.17 ± 0.59
Basal Part of Pons5.63 ± 0.34
Cerebellar Cortex5.78 ± 0.29
Cerebellar Nuclei5.26 ± 0.51
Claustrum4.88 ± 0.39
Epithalamus5.35 ± 0.39
Frontal Lobe5.46 ± 0.42
Globus Pallidus4.59 ± 0.28
Hypothalamus5.4 ± 0.39
Insula5.45 ± 0.4
Limbic Lobe5.42 ± 0.47
Mesencephalon5.28 ± 0.36
Myelencephalon5.38 ± 0.45
Occipital Lobe5.35 ± 0.36
Parietal Lobe5.36 ± 0.41
Pontine Tegmentum5.21 ± 0.51
Striatum5.14 ± 0.41
Subthalamus5.32 ± 0.15
Temporal Lobe5.55 ± 0.37
Thalamus5.32 ± 0.41
White Matter4.91 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp335CBCerebellum15.61
17.31
Zfp335CTXCerebral cortex35.87
26.58
Zfp335HIPHippocampal region29.44
33.32
Zfp335HPFHippocampal formation27.17
26.02
Zfp335HYHypothalamus7.8
5.37
Zfp335LSXLateral septal complex7.84
4.68
Zfp335MBMidbrain16.82
15.62
Zfp335MYMedulla14.92
14.56
Zfp335OLFOlfactory bulb37.53
28.29
Zfp335PPons12
11.49
Zfp335PALPallidum15.44
11.81
Zfp335RHPRetrohippocampal region23.18
15.71
Zfp335sAMYStriatum-like amygdalar nuclei19.54
12.78
Zfp335STRStriatum19.24
12.41
Zfp335STRdStriatum dorsal region19.22
12.54
Zfp335STRvStriatum ventral region26.21
16.16
Zfp335THThalamus17.63
12.99
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00504864 28 409 436 TPVEAGVSQSDAENAAPSCPDEHDTLPR Peptide Atlas
ZN335_HUMAN_350 6 350 355 RPGRPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018