AutismKB 2.0

Annotation Detail for PRSS22


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Basic Information Top
Gene Symbol:PRSS22 ( BSSP-4,MGC9599,hBSSP-4 )
Gene Full Name: protease, serine, 22
Band: 16p13.3
Quick LinksEntrez ID:64063; OMIM: 609343; Uniprot ID:BSSP4_HUMAN; ENSEMBL ID: ENSG00000005001; HGNC ID: 14368
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult28 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal21 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus2 / 2020998
eye0 / 2110540 
heart0 / 896260 
intestine5 / 23447221
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth4 / 6705259
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach10 / 96619103
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205847_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.65
Adipocyte15.25
AdrenalCortex16.45
Adrenalgland16
Amygdala19.5
Appendix14.7
AtrioventricularNode11.4
BDCA4+_DentriticCells15.1
Bonemarrow23.1
BronchialEpithelialCells15.3
CD105+_Endothelial14.1
CD14+_Monocytes15
CD19+_BCells(neg._sel.)15.65
CD33+_Myeloid16.9
CD34+15.65
CD4+_Tcells15.6
CD56+_NKCells16.75
CD71+_EarlyErythroid14.5
CD8+_Tcells12.6
CardiacMyocytes18.5
Caudatenucleus13.9
Cerebellum15.35
CerebellumPeduncles19.6
CiliaryGanglion10.5
CingulateCortex15.95
Colorectaladenocarcinoma25.15
DorsalRootGanglion11.7
FetalThyroid15.55
Fetalbrain15.25
Fetalliver14.65
Fetallung16.8
GlobusPallidus11.45
Heart21.9
Hypothalamus19.85
Kidney16.6
Leukemia_chronicMyelogenousK-56216.2
Leukemia_promyelocytic-HL-6013.65
Leukemialymphoblastic(MOLT-4)14.1
Liver20.15
Lung16.95
Lymphnode14.45
Lymphoma_burkitts(Daudi)21.3
Lymphoma_burkitts(Raji)20.8
MedullaOblongata15.3
OccipitalLobe13.9
OlfactoryBulb12.15
Ovary10.2
Pancreas15.05
PancreaticIslet26.15
ParietalLobe16.45
Pituitary24.7
Placenta15.5
Pons14.7
PrefrontalCortex19.15
Prostate29.15
Salivarygland12.8
SkeletalMuscle17.5
Skin11.7
SmoothMuscle16.25
Spinalcord19.5
SubthalamicNucleus14.2
SuperiorCervicalGanglion21.25
TemporalLobe13.85
Testis13.4
TestisGermCell12.8
TestisIntersitial13
TestisLeydigCell15.3
TestisSeminiferousTubule17.3
Thalamus15.9
Thymus12.05
Thyroid22.3
Tongue29.65
Tonsil31.05
Trachea18.05
TrigeminalGanglion14.5
Uterus10.75
UterusCorpus13.95
WholeBlood16.7
Wholebrain12.9
colon15.5
pineal_day16.98
pineal_night15.48
retina18.65
small_intestine14.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1313_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.61 ± 1.09
Basal Forebrain2.2 ± 0.28
Basal Part of Pons2.32 ± 0.66
Cerebellar Cortex2.94 ± 0.57
Cerebellar Nuclei2.78 ± 0.89
Claustrum3.36 ± 0.95
Epithalamus2 ± 1
Frontal Lobe2.19 ± 0.78
Globus Pallidus2.47 ± 0.84
Hypothalamus2.48 ± 1.11
Insula1.87 ± 0.42
Limbic Lobe2.26 ± 0.8
Mesencephalon2.42 ± 0.78
Myelencephalon2.31 ± 0.76
Occipital Lobe2.32 ± 0.82
Parietal Lobe2.28 ± 0.82
Pontine Tegmentum2.29 ± 0.86
Striatum2.13 ± 0.78
Subthalamus2.15 ± 0.44
Temporal Lobe2.27 ± 0.85
Thalamus2.28 ± 0.71
White Matter3.29 ± 0.74
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prss22CBCerebellum10.2
12.44
Prss22CTXCerebral cortex9.59
6.4
Prss22HIPHippocampal region3.12
2.73
Prss22HPFHippocampal formation6.11
5.06
Prss22HYHypothalamus0.48
0.91
Prss22LSXLateral septal complex0.56
0.44
Prss22MBMidbrain3.04
3.18
Prss22MYMedulla3.85
3.14
Prss22OLFOlfactory bulb12.06
9.28
Prss22PPons7.07
7.19
Prss22PALPallidum0.91
0.92
Prss22RHPRetrohippocampal region12.37
9.11
Prss22sAMYStriatum-like amygdalar nuclei0.46
0.67
Prss22STRStriatum1.29
1.13
Prss22STRdStriatum dorsal region0.79
0.73
Prss22STRvStriatum ventral region3.63
2.8
Prss22THThalamus0.66
0.64
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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