AutismKB 2.0

Annotation Detail for SLC39A8


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Basic Information Top
Gene Symbol:SLC39A8 ( BIGM103,LZT-Hs6,ZIP8 )
Gene Full Name: solute carrier family 39 (zinc transporter), member 8
Band: 4q24
Quick LinksEntrez ID:64116; OMIM: 608732; Uniprot ID:S39A8_HUMAN; ENSEMBL ID: ENSG00000138821; HGNC ID: 20862
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult112 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor5 / 34366145
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor14 / 26384553
glioma9 / 10688384
head and neck tumor2 / 13630214
kidney tumor7 / 68959101
leukemia14 / 95842146
liver tumor4 / 9635941
lung tumor10 / 10312796
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal126 / 336030737
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow2 / 4880140
brain27 / 110098924
cervix6 / 48171124
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine32 / 234472136
kidney18 / 21177784
larynx1 / 2414541
liver8 / 20774338
lung26 / 33697477
lymph0 / 442700 
lymph node7 / 9161076
mammary gland10 / 15327165
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid10 / 20539486
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta50 / 280825178
prostate7 / 18934536
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach0 / 966190 
testis6 / 33044218
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219869_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts72.3
Adipocyte10.1
AdrenalCortex5.05
Adrenalgland4.15
Amygdala5.15
Appendix5.15
AtrioventricularNode3.75
BDCA4+_DentriticCells6.65
Bonemarrow5
BronchialEpithelialCells4.9
CD105+_Endothelial88.25
CD14+_Monocytes5.25
CD19+_BCells(neg._sel.)5.35
CD33+_Myeloid6.45
CD34+102.7
CD4+_Tcells6
CD56+_NKCells8.35
CD71+_EarlyErythroid9.15
CD8+_Tcells5.55
CardiacMyocytes6.25
Caudatenucleus4.4
Cerebellum4.05
CerebellumPeduncles5.7
CiliaryGanglion3.5
CingulateCortex5.05
Colorectaladenocarcinoma4.95
DorsalRootGanglion3.7
FetalThyroid4.7
Fetalbrain4.9
Fetalliver7.45
Fetallung11.45
GlobusPallidus3.6
Heart6.4
Hypothalamus5.35
Kidney4.05
Leukemia_chronicMyelogenousK-5625.05
Leukemia_promyelocytic-HL-604.45
Leukemialymphoblastic(MOLT-4)31.3
Liver6.6
Lung43.95
Lymphnode4.25
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)6.95
MedullaOblongata6.65
OccipitalLobe4.55
OlfactoryBulb3.8
Ovary3.3
Pancreas5.4
PancreaticIslet5.5
ParietalLobe5.2
Pituitary6.3
Placenta120.8
Pons4.7
PrefrontalCortex6.15
Prostate5.8
Salivarygland29.45
SkeletalMuscle5.8
Skin3.8
SmoothMuscle9.85
Spinalcord5.3
SubthalamicNucleus4.6
SuperiorCervicalGanglion5.9
TemporalLobe4.55
Testis4.25
TestisGermCell4.05
TestisIntersitial4.15
TestisLeydigCell4.85
TestisSeminiferousTubule4.15
Thalamus5.1
Thymus3.95
Thyroid6.25
Tongue4.85
Tonsil4.8
Trachea23.2
TrigeminalGanglion5.95
Uterus4.05
UterusCorpus4.4
WholeBlood5.3
Wholebrain4.15
colon13.9
pineal_day5.96
pineal_night5.9
retina5.975
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P210525
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.06 ± 0.99
Basal Forebrain1.6 ± 0.21
Basal Part of Pons1.33 ± 0.34
Cerebellar Cortex1.44 ± 0.65
Cerebellar Nuclei1.96 ± 0.75
Claustrum2.49 ± 0.83
Epithalamus1.37 ± 0.72
Frontal Lobe1.45 ± 0.58
Globus Pallidus2.21 ± 0.3
Hypothalamus1.67 ± 0.64
Insula1.53 ± 0.52
Limbic Lobe1.61 ± 0.59
Mesencephalon1.76 ± 0.63
Myelencephalon1.64 ± 0.65
Occipital Lobe1.68 ± 0.58
Parietal Lobe1.62 ± 0.63
Pontine Tegmentum1.66 ± 0.64
Striatum1.85 ± 0.55
Subthalamus1.83 ± 0.63
Temporal Lobe1.53 ± 0.59
Thalamus1.62 ± 0.55
White Matter2.19 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc39a8CBCerebellum1.41
2.76
Slc39a8CTXCerebral cortex1.78
2.13
Slc39a8HIPHippocampal region0.79
0.7
Slc39a8HPFHippocampal formation0.7
0.63
Slc39a8HYHypothalamus0.82
1.34
Slc39a8LSXLateral septal complex0.08
0.08
Slc39a8MBMidbrain0.54
0.73
Slc39a8MYMedulla0.59
0.67
Slc39a8OLFOlfactory bulb0.82
0.67
Slc39a8PPons0.42
0.62
Slc39a8PALPallidum0.26
0.23
Slc39a8RHPRetrohippocampal region0.55
0.47
Slc39a8sAMYStriatum-like amygdalar nuclei0.4
0.32
Slc39a8STRStriatum0.3
0.27
Slc39a8STRdStriatum dorsal region0.32
0.31
Slc39a8STRvStriatum ventral region0.22
0.17
Slc39a8THThalamus1.93
2.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040325 22 97 118 FSVICPAVLQQLNFHPCEDRPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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