AutismKB 2.0

Annotation Detail for MAP2K4


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Basic Information Top
Gene Symbol:MAP2K4 ( JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1 )
Gene Full Name: mitogen-activated protein kinase kinase 4
Band: 17p12
Quick LinksEntrez ID:6416; OMIM: 601335; Uniprot ID:MP2K4_HUMAN; ENSEMBL ID: ENSG00000065559; HGNC ID: 6844
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst2 / 6231932
fetus36 / 56401263
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult80 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor6 / 6895987
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal287 / 336030785
ovarian tumor5 / 7668265
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer10 / 10268097
retinoblastoma4 / 4635686
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites5 / 40015124
bladder2 / 2975767
blood0 / 1234780 
bone2 / 7165527
bone marrow2 / 4880140
brain170 / 1100989154
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye17 / 21105480
heart1 / 8962611
intestine9 / 23447238
kidney12 / 21177756
larynx0 / 241450 
liver6 / 20774328
lung5 / 33697414
lymph1 / 4427022
lymph node6 / 9161065
mammary gland11 / 15327171
mouth3 / 6705244
muscle2 / 10771518
nerve1 / 1576863
ovary5 / 10205148
pancreas11 / 21481251
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta16 / 28082556
prostate17 / 18934589
salivary gland0 / 201550 
skin3 / 21057414
spleen3 / 5395255
stomach0 / 966190 
testis13 / 33044239
thymus3 / 8113136
thyroid2 / 4747342
tonsil5 / 16999294
trachea6 / 52413114
umbilical cord0 / 136800 
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203266_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.45
Adipocyte11.75
AdrenalCortex12.8
Adrenalgland9.05
Amygdala248.45
Appendix14.75
AtrioventricularNode11.8
BDCA4+_DentriticCells17.15
Bonemarrow10.7
BronchialEpithelialCells34.05
CD105+_Endothelial24.55
CD14+_Monocytes30.85
CD19+_BCells(neg._sel.)26.85
CD33+_Myeloid22.85
CD34+19.15
CD4+_Tcells20.4
CD56+_NKCells17.15
CD71+_EarlyErythroid15.75
CD8+_Tcells25.75
CardiacMyocytes22.45
Caudatenucleus34.65
Cerebellum9.4
CerebellumPeduncles16.7
CiliaryGanglion10.9
CingulateCortex97.7
Colorectaladenocarcinoma13.2
DorsalRootGanglion11.85
FetalThyroid11.4
Fetalbrain63.3
Fetalliver12.2
Fetallung11.4
GlobusPallidus73.25
Heart13.65
Hypothalamus132.7
Kidney8.1
Leukemia_chronicMyelogenousK-5629.25
Leukemia_promyelocytic-HL-6011.65
Leukemialymphoblastic(MOLT-4)9.15
Liver11.75
Lung10.65
Lymphnode10.3
Lymphoma_burkitts(Daudi)14.85
Lymphoma_burkitts(Raji)17.4
MedullaOblongata77.75
OccipitalLobe105.25
OlfactoryBulb10.05
Ovary8.7
Pancreas8.2
PancreaticIslet14.15
ParietalLobe66.8
Pituitary21.2
Placenta16.2
Pons45.3
PrefrontalCortex170.65
Prostate15.7
Salivarygland10.65
SkeletalMuscle18.95
Skin13.45
SmoothMuscle19.45
Spinalcord37.3
SubthalamicNucleus109.55
SuperiorCervicalGanglion16.05
TemporalLobe57.85
Testis9.2
TestisGermCell23.65
TestisIntersitial10.55
TestisLeydigCell12.5
TestisSeminiferousTubule10.4
Thalamus123.6
Thymus8.05
Thyroid21.95
Tongue14.6
Tonsil11.15
Trachea10.3
TrigeminalGanglion19.15
Uterus12.05
UterusCorpus12.8
WholeBlood57.7
Wholebrain67.6
colon12.5
pineal_day44.28
pineal_night43.46
retina16.15
small_intestine12.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16229_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.45 ± 0.37
Basal Forebrain6.95 ± 0.24
Basal Part of Pons7.8 ± 0.23
Cerebellar Cortex6.96 ± 0.32
Cerebellar Nuclei7.14 ± 0.48
Claustrum7.42 ± 0.39
Epithalamus6.5 ± 0.6
Frontal Lobe7.48 ± 0.42
Globus Pallidus6.4 ± 0.9
Hypothalamus7.05 ± 0.55
Insula7.45 ± 0.2
Limbic Lobe7.66 ± 0.46
Mesencephalon7.23 ± 0.63
Myelencephalon7.23 ± 0.58
Occipital Lobe7.13 ± 0.48
Parietal Lobe7.45 ± 0.51
Pontine Tegmentum7.2 ± 0.41
Striatum6.61 ± 0.67
Subthalamus7.15 ± 0.3
Temporal Lobe7.47 ± 0.29
Thalamus7.15 ± 0.37
White Matter6.17 ± 0.8
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map2k4CBCerebellum37.26
81.21
Map2k4CTXCerebral cortex100
100
Map2k4HIPHippocampal region100
100
Map2k4HPFHippocampal formation100
100
Map2k4HYHypothalamus100
100
Map2k4LSXLateral septal complex100
100
Map2k4MBMidbrain100
100
Map2k4MYMedulla94.84
100
Map2k4OLFOlfactory bulb100
100
Map2k4PPons100
100
Map2k4PALPallidum100
100
Map2k4RHPRetrohippocampal region100
100
Map2k4sAMYStriatum-like amygdalar nuclei100
100
Map2k4STRStriatum99.93
98.28
Map2k4STRdStriatum dorsal region88.34
81.52
Map2k4STRvStriatum ventral region100
100
Map2k4THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004737 16 245 260 LCDFGISGQLVDSIAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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