AutismKB 2.0

Annotation Detail for SFRP1


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Basic Information Top
Gene Symbol:SFRP1 ( FRP,FRP-1,FRP1,FrzA,SARP2 )
Gene Full Name: secreted frizzled-related protein 1
Band: 8p11.21
Quick LinksEntrez ID:6422; OMIM: 604156; Uniprot ID:SFRP1_HUMAN; ENSEMBL ID: ENSG00000104332; HGNC ID: 10776
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body15 / 70761211
blastocyst15 / 62319240
fetus56 / 56401299
neonate1 / 3109732
infant2 / 2362084
juvenile4 / 5555671
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma11 / 82823132
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor13 / 26384549
glioma1 / 1068839
head and neck tumor25 / 136302183
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor15 / 96359155
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal248 / 336030773
ovarian tumor22 / 76682286
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor10 / 12494980
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain31 / 110098928
cervix3 / 4817162
connective tissue16 / 149255107
ear1 / 1621261
embryonic tissue39 / 215722180
esophagus0 / 202090 
eye17 / 21105480
heart24 / 89626267
intestine2 / 2344728
kidney24 / 211777113
larynx0 / 241450 
liver18 / 20774386
lung30 / 33697489
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth2 / 6705229
muscle3 / 10771527
nerve2 / 15768126
ovary23 / 102051225
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta16 / 28082556
prostate3 / 18934515
salivary gland3 / 20155148
skin20 / 21057494
spleen0 / 539520 
stomach2 / 9661920
testis9 / 33044227
thymus2 / 8113124
thyroid24 / 47473505
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus18 / 23287877
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202037_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.25
Adipocyte10.3
AdrenalCortex6.25
Adrenalgland5.05
Amygdala10.75
Appendix10.75
AtrioventricularNode5.5
BDCA4+_DentriticCells5.35
Bonemarrow5.85
BronchialEpithelialCells14.2
CD105+_Endothelial5.25
CD14+_Monocytes5.7
CD19+_BCells(neg._sel.)5.35
CD33+_Myeloid6.6
CD34+6.45
CD4+_Tcells5.45
CD56+_NKCells5.95
CD71+_EarlyErythroid4.75
CD8+_Tcells4.85
CardiacMyocytes13.15
Caudatenucleus11.5
Cerebellum9.2
CerebellumPeduncles10.1
CiliaryGanglion13.6
CingulateCortex6.35
Colorectaladenocarcinoma5.85
DorsalRootGanglion6
FetalThyroid7.25
Fetalbrain6.05
Fetalliver5.8
Fetallung4.65
GlobusPallidus4.4
Heart10.7
Hypothalamus14.9
Kidney103.4
Leukemia_chronicMyelogenousK-5625.15
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)4.6
Liver9.35
Lung6.4
Lymphnode5.05
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)8.2
MedullaOblongata5.85
OccipitalLobe7
OlfactoryBulb7.05
Ovary25.25
Pancreas4.5
PancreaticIslet6.45
ParietalLobe6.3
Pituitary6.7
Placenta31.7
Pons6.15
PrefrontalCortex9.25
Prostate12.05
Salivarygland428.2
SkeletalMuscle6.85
Skin331.1
SmoothMuscle268.55
Spinalcord6.45
SubthalamicNucleus5.4
SuperiorCervicalGanglion8.25
TemporalLobe5.45
Testis40.65
TestisGermCell80
TestisIntersitial19.05
TestisLeydigCell34.2
TestisSeminiferousTubule5.4
Thalamus13.05
Thymus4.75
Thyroid15.3
Tongue201
Tonsil5.4
Trachea69.6
TrigeminalGanglion6.1
Uterus264.3
UterusCorpus33.25
WholeBlood5.95
Wholebrain5.55
colon9.55
pineal_day6.8
pineal_night37.86
retina230.625
small_intestine59.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P10121
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.99 ± 0.75
Basal Forebrain6.68 ± 0.49
Basal Part of Pons6.88 ± 0.27
Cerebellar Cortex6.58 ± 0.29
Cerebellar Nuclei6.7 ± 0.95
Claustrum6.47 ± 0.66
Epithalamus5.32 ± 0.85
Frontal Lobe5.82 ± 0.78
Globus Pallidus6.1 ± 0.78
Hypothalamus5.47 ± 0.48
Insula5.42 ± 0.66
Limbic Lobe5.81 ± 0.87
Mesencephalon5.98 ± 0.63
Myelencephalon6.05 ± 0.83
Occipital Lobe5.59 ± 0.61
Parietal Lobe5.83 ± 0.81
Pontine Tegmentum5.75 ± 0.7
Striatum6.65 ± 0.96
Subthalamus6.54 ± 0.48
Temporal Lobe5.77 ± 0.7
Thalamus5.92 ± 0.63
White Matter8.44 ± 0.81
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sfrp1CBCerebellum55.25
34.95
Sfrp1CTXCerebral cortex48.52
25.92
Sfrp1HIPHippocampal region32.95
16.05
Sfrp1HPFHippocampal formation37.68
21.08
Sfrp1HYHypothalamus15.49
8.8
Sfrp1LSXLateral septal complex17.67
9.36
Sfrp1MBMidbrain17.71
13.88
Sfrp1MYMedulla46.08
36.24
Sfrp1OLFOlfactory bulb59.6
28.6
Sfrp1PPons35.74
30.42
Sfrp1PALPallidum18.72
10.42
Sfrp1RHPRetrohippocampal region44.45
26.72
Sfrp1sAMYStriatum-like amygdalar nuclei27.97
14.18
Sfrp1STRStriatum23.52
11.81
Sfrp1STRdStriatum dorsal region18.47
9.62
Sfrp1STRvStriatum ventral region38.52
16.96
Sfrp1THThalamus11
6.02
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096855 16 195 210 SEAIIEHLCASEFALR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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