AutismKB 2.0

Annotation Detail for ROBO3


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Basic Information Top
Gene Symbol:ROBO3 ( FLJ21044,HGPPS,HGPS,RBIG1,RIG1 )
Gene Full Name: roundabout, axon guidance receptor, homolog 3 (Drosophila)
Band: 11q24.2
Quick LinksEntrez ID:64221; OMIM: 608630; Uniprot ID:ROBO3_HUMAN; ENSEMBL ID: ENSG00000154134; HGNC ID: 13433
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor11 / 26384541
glioma7 / 10688365
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal96 / 336030728
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow1 / 4880120
brain53 / 110098948
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye4 / 21105418
heart5 / 8962655
intestine6 / 23447225
kidney1 / 2117774
larynx1 / 2414541
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate7 / 18934536
salivary gland0 / 201550 
skin1 / 2105744
spleen6 / 53952111
stomach0 / 966190 
testis12 / 33044236
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219550_at
Cell line Expression level Expression bar
721_B_lymphoblasts6
Adipocyte6.1
AdrenalCortex7.4
Adrenalgland5.25
Amygdala6.55
Appendix6.1
AtrioventricularNode6
BDCA4+_DentriticCells6.6
Bonemarrow5.8
BronchialEpithelialCells5.85
CD105+_Endothelial4.95
CD14+_Monocytes6.4
CD19+_BCells(neg._sel.)6.2
CD33+_Myeloid6.6
CD34+18
CD4+_Tcells8.4
CD56+_NKCells6.85
CD71+_EarlyErythroid5.5
CD8+_Tcells14.85
CardiacMyocytes8.1
Caudatenucleus6.6
Cerebellum5.75
CerebellumPeduncles8.6
CiliaryGanglion4.8
CingulateCortex8.05
Colorectaladenocarcinoma5.85
DorsalRootGanglion6.2
FetalThyroid7.35
Fetalbrain6.6
Fetalliver5
Fetallung6.4
GlobusPallidus5.05
Heart8.1
Hypothalamus8.4
Kidney4.75
Leukemia_chronicMyelogenousK-5627.3
Leukemia_promyelocytic-HL-605.25
Leukemialymphoblastic(MOLT-4)4.75
Liver7.7
Lung6.6
Lymphnode8.75
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)8.25
MedullaOblongata5.45
OccipitalLobe5.55
OlfactoryBulb6.6
Ovary4.3
Pancreas4.5
PancreaticIslet6.2
ParietalLobe8.35
Pituitary7.1
Placenta5.55
Pons5.6
PrefrontalCortex7.65
Prostate6.9
Salivarygland4.7
SkeletalMuscle7.2
Skin4.5
SmoothMuscle6.85
Spinalcord13.65
SubthalamicNucleus5.5
SuperiorCervicalGanglion6.45
TemporalLobe5.9
Testis5.1
TestisGermCell4.9
TestisIntersitial5.3
TestisLeydigCell5.85
TestisSeminiferousTubule5
Thalamus6.75
Thymus4.7
Thyroid7.4
Tongue5.75
Tonsil6.05
Trachea4.95
TrigeminalGanglion5.85
Uterus4.85
UterusCorpus6.25
WholeBlood6.35
Wholebrain5.25
colon5.95
pineal_day7.3
pineal_night7.14
retina13.875
small_intestine5.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P85143
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.51 ± 0.66
Basal Forebrain5.4 ± 0.43
Basal Part of Pons5.5 ± 0.36
Cerebellar Cortex5.16 ± 0.47
Cerebellar Nuclei5.69 ± 0.72
Claustrum5.58 ± 0.77
Epithalamus4.54 ± 0.52
Frontal Lobe5.3 ± 0.5
Globus Pallidus6.01 ± 0.49
Hypothalamus4.72 ± 0.55
Insula5.2 ± 0.4
Limbic Lobe5.43 ± 0.57
Mesencephalon5.35 ± 0.44
Myelencephalon5.4 ± 0.61
Occipital Lobe5.49 ± 0.75
Parietal Lobe5.3 ± 0.53
Pontine Tegmentum5.27 ± 0.59
Striatum5.62 ± 0.52
Subthalamus5.39 ± 0.34
Temporal Lobe5.23 ± 0.56
Thalamus5.43 ± 0.41
White Matter5.62 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Robo3CBCerebellum93.99
100
Robo3CTXCerebral cortex99.5
75.15
Robo3HIPHippocampal region75.28
100
Robo3HPFHippocampal formation78.91
94.06
Robo3HYHypothalamus22.9
19.22
Robo3LSXLateral septal complex34.35
22.36
Robo3MBMidbrain28.43
24.97
Robo3MYMedulla41.44
40.79
Robo3OLFOlfactory bulb73.88
67.68
Robo3PPons29.02
28.9
Robo3PALPallidum32.59
28.07
Robo3RHPRetrohippocampal region84.95
68.75
Robo3sAMYStriatum-like amygdalar nuclei80.88
63.42
Robo3STRStriatum71.76
52.1
Robo3STRdStriatum dorsal region77.83
55.68
Robo3STRvStriatum ventral region65.34
48.57
Robo3THThalamus55.5
50.19
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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