AutismKB 2.0

Annotation Detail for MS4A6A


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Basic Information Top
Gene Symbol:MS4A6A ( 4SPAN3,4SPAN3.2,CD20L3,MGC131944,MGC22650,MS4A6,MST090,MSTP090 )
Gene Full Name: membrane-spanning 4-domains, subfamily A, member 6A
Band: 11q12.2
Quick LinksEntrez ID:64231; OMIM: 606548; Uniprot ID:M4A6A_HUMAN; ENSEMBL ID: ENSG00000110077; HGNC ID: 13375
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus31 / 56401254
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor8 / 26384530
glioma10 / 10688393
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia9 / 9725092
normal203 / 336030760
ovarian tumor9 / 76682117
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites0 / 400150 
bladder0 / 297570 
blood8 / 12347864
bone2 / 7165527
bone marrow1 / 4880120
brain21 / 110098919
cervix0 / 481710 
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine14 / 23447259
kidney22 / 211777103
larynx0 / 241450 
liver11 / 20774352
lung23 / 33697468
lymph0 / 442700 
lymph node6 / 9161065
mammary gland1 / 1532716
mouth1 / 6705214
muscle10 / 10771592
nerve1 / 1576863
ovary9 / 10205188
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx15 / 41328362
pituitary gland1 / 1658560
placenta22 / 28082578
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen6 / 53952111
stomach3 / 9661931
testis1 / 3304423
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus29 / 232878124
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219666_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.2
Adipocyte3.3
AdrenalCortex3.55
Adrenalgland4.05
Amygdala3.6
Appendix3.9
AtrioventricularNode3.25
BDCA4+_DentriticCells894.5
Bonemarrow17
BronchialEpithelialCells3.3
CD105+_Endothelial48.9
CD14+_Monocytes1985.75
CD19+_BCells(neg._sel.)3.55
CD33+_Myeloid1966.7
CD34+11.35
CD4+_Tcells3.7
CD56+_NKCells4
CD71+_EarlyErythroid3.15
CD8+_Tcells3.25
CardiacMyocytes6.5
Caudatenucleus3.05
Cerebellum2.75
CerebellumPeduncles3.85
CiliaryGanglion3.05
CingulateCortex3.5
Colorectaladenocarcinoma3.35
DorsalRootGanglion2.7
FetalThyroid3.3
Fetalbrain3.45
Fetalliver5.3
Fetallung4.7
GlobusPallidus2.5
Heart4.25
Hypothalamus3.7
Kidney2.75
Leukemia_chronicMyelogenousK-5623.05
Leukemia_promyelocytic-HL-603
Leukemialymphoblastic(MOLT-4)2.7
Liver4.95
Lung4.4
Lymphnode10.6
Lymphoma_burkitts(Daudi)4.3
Lymphoma_burkitts(Raji)4.7
MedullaOblongata3.15
OccipitalLobe3
OlfactoryBulb6.4
Ovary2.45
Pancreas2.8
PancreaticIslet6.05
ParietalLobe3.55
Pituitary4.1
Placenta7.2
Pons3.2
PrefrontalCortex4.15
Prostate3.95
Salivarygland5.5
SkeletalMuscle3.8
Skin2.65
SmoothMuscle3.85
Spinalcord3.9
SubthalamicNucleus3.05
SuperiorCervicalGanglion4.1
TemporalLobe3.1
Testis2.9
TestisGermCell3.05
TestisIntersitial2.9
TestisLeydigCell3.4
TestisSeminiferousTubule2.95
Thalamus3.4
Thymus2.75
Thyroid4.3
Tongue3.35
Tonsil5.4
Trachea3
TrigeminalGanglion4.25
Uterus5.05
UterusCorpus3.45
WholeBlood409.9
Wholebrain2.85
colon3.45
pineal_day4.28
pineal_night4.38
retina7.575
small_intestine8.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P36120
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.83 ± 1.04
Basal Forebrain2.53 ± 0.39
Basal Part of Pons2.82 ± 0.64
Cerebellar Cortex2.27 ± 0.54
Cerebellar Nuclei3.64 ± 0.65
Claustrum3.23 ± 0.73
Epithalamus3.82 ± 0.86
Frontal Lobe2.41 ± 0.81
Globus Pallidus4.51 ± 0.59
Hypothalamus2.67 ± 1.27
Insula2.48 ± 0.76
Limbic Lobe2.42 ± 0.68
Mesencephalon2.61 ± 0.62
Myelencephalon2.63 ± 0.82
Occipital Lobe2.44 ± 0.61
Parietal Lobe2.43 ± 0.76
Pontine Tegmentum2.51 ± 0.71
Striatum3.41 ± 0.77
Subthalamus2.64 ± 0.72
Temporal Lobe2.45 ± 0.81
Thalamus2.5 ± 0.6
White Matter3.52 ± 0.88
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ms4a6bCBCerebellum68.72
100
Ms4a6bCTXCerebral cortex100
100
Ms4a6bHIPHippocampal region100
100
Ms4a6bHPFHippocampal formation100
100
Ms4a6bHYHypothalamus91.53
89.41
Ms4a6bLSXLateral septal complex61.29
58.26
Ms4a6bMBMidbrain99.2
100
Ms4a6bMYMedulla100
100
Ms4a6bOLFOlfactory bulb88.96
92.99
Ms4a6bPPons100
100
Ms4a6bPALPallidum98.09
100
Ms4a6bRHPRetrohippocampal region100
100
Ms4a6bsAMYStriatum-like amygdalar nuclei100
100
Ms4a6bSTRStriatum100
100
Ms4a6bSTRdStriatum dorsal region100
100
Ms4a6bSTRvStriatum ventral region100
100
Ms4a6bTHThalamus99.57
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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