Annotation Detail for NSD1
Basic Information Top
| Gene Symbol: | NSD1 ( ARA267,DKFZp666C163,FLJ10684,FLJ22263,FLJ44628,KMT3B,SOTOS,STO ) |
|---|---|
| Gene Full Name: | nuclear receptor binding SET domain protein 1 |
| Band: | 5q35.3 |
| Quick Links | Entrez ID:64324; OMIM: 606681; Uniprot ID:NSD1_HUMAN; ENSEMBL ID: ENSG00000165671; HGNC ID: 14234 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.106861
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 7 / 70761 | 98 |  |
| blastocyst | 7 / 62319 | 112 | |
| fetus | 40 / 564012 | 70 | |
| neonate | 0 / 31097 | 0 | |
| infant | 2 / 23620 | 84 | |
| juvenile | 4 / 55556 | 71 | |
| adult | 119 / 1939121 | 61 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 |  |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 5 / 82823 | 60 | |
| colorectal tumor | 8 / 114246 | 70 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 9 / 119369 | 75 | |
| germ cell tumor | 19 / 263845 | 72 | |
| glioma | 5 / 106883 | 46 | |
| head and neck tumor | 10 / 136302 | 73 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 14 / 95842 | 146 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 5 / 103127 | 48 | |
| lymphoma | 2 / 71755 | 27 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 181 / 3360307 | 53 | |
| ovarian tumor | 6 / 76682 | 78 | |
| pancreatic tumor | 5 / 104616 | 47 | |
| primitive neuroectodermal tumor of the CNS | 3 / 125680 | 23 | |
| prostate cancer | 11 / 102680 | 107 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 3 / 124949 | 24 | |
| soft tissue/muscle tissue tumor | 7 / 125191 | 55 | |
| uterine tumor | 13 / 90257 | 144 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 6 / 40015 | 149 | |
| bladder | 2 / 29757 | 67 | |
| blood | 10 / 123478 | 80 | |
| bone | 7 / 71655 | 97 | |
| bone marrow | 2 / 48801 | 40 | |
| brain | 63 / 1100989 | 57 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 18 / 215722 | 83 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 19 / 211054 | 90 | |
| heart | 8 / 89626 | 89 | |
| intestine | 16 / 234472 | 68 | |
| kidney | 13 / 211777 | 61 | |
| larynx | 1 / 24145 | 41 | |
| liver | 5 / 207743 | 24 | |
| lung | 15 / 336974 | 44 | |
| lymph | 2 / 44270 | 45 | |
| lymph node | 7 / 91610 | 76 | |
| mammary gland | 6 / 153271 | 39 | |
| mouth | 4 / 67052 | 59 | |
| muscle | 2 / 107715 | 18 | |
| nerve | 3 / 15768 | 190 | |
| ovary | 7 / 102051 | 68 | |
| pancreas | 6 / 214812 | 27 | |
| parathyroid | 1 / 20539 | 48 | |
| pharynx | 5 / 41328 | 120 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 4 / 280825 | 14 | |
| prostate | 11 / 189345 | 58 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 4 / 210574 | 18 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 4 / 96619 | 41 | |
| testis | 32 / 330442 | 96 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 7 / 47473 | 147 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 27 / 232878 | 115 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 219084_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.6 |  |
| Adipocyte | 4.3 | |
| AdrenalCortex | 4.5 | |
| Adrenalgland | 3.7 | |
| Amygdala | 4.65 | |
| Appendix | 4.75 | |
| AtrioventricularNode | 3.25 | |
| BDCA4+_DentriticCells | 5 | |
| Bonemarrow | 4.6 | |
| BronchialEpithelialCells | 4.45 | |
| CD105+_Endothelial | 4.5 | |
| CD14+_Monocytes | 4.7 | |
| CD19+_BCells(neg._sel.) | 4.75 | |
| CD33+_Myeloid | 5.7 | |
| CD34+ | 5.6 | |
| CD4+_Tcells | 4.85 | |
| CD56+_NKCells | 5.35 | |
| CD71+_EarlyErythroid | 3.9 | |
| CD8+_Tcells | 4.55 | |
| CardiacMyocytes | 5.45 | |
| Caudatenucleus | 3.95 | |
| Cerebellum | 3.55 | |
| CerebellumPeduncles | 4.95 | |
| CiliaryGanglion | 3.1 | |
| CingulateCortex | 4.45 | |
| Colorectaladenocarcinoma | 4.7 | |
| DorsalRootGanglion | 3.35 | |
| FetalThyroid | 4.25 | |
| Fetalbrain | 5.15 | |
| Fetalliver | 3.75 | |
| Fetallung | 3.7 | |
| GlobusPallidus | 3.15 | |
| Heart | 5.55 | |
| Hypothalamus | 4.65 | |
| Kidney | 3.5 | |
| Leukemia_chronicMyelogenousK-562 | 3.95 | |
| Leukemia_promyelocytic-HL-60 | 3.95 | |
| Leukemialymphoblastic(MOLT-4) | 3.85 | |
| Liver | 5.7 | |
| Lung | 4.5 | |
| Lymphnode | 5 | |
| Lymphoma_burkitts(Daudi) | 6.85 | |
| Lymphoma_burkitts(Raji) | 5.55 | |
| MedullaOblongata | 4.05 | |
| OccipitalLobe | 3.95 | |
| OlfactoryBulb | 3.45 | |
| Ovary | 2.9 | |
| Pancreas | 3.5 | |
| PancreaticIslet | 4.65 | |
| ParietalLobe | 4.3 | |
| Pituitary | 5.15 | |
| Placenta | 4.6 | |
| Pons | 4.15 | |
| PrefrontalCortex | 5.5 | |
| Prostate | 5.2 | |
| Salivarygland | 3.45 | |
| SkeletalMuscle | 4.85 | |
| Skin | 3.3 | |
| SmoothMuscle | 5 | |
| Spinalcord | 5.45 | |
| SubthalamicNucleus | 3.95 | |
| SuperiorCervicalGanglion | 5.1 | |
| TemporalLobe | 3.95 | |
| Testis | 9.2 | |
| TestisGermCell | 8.85 | |
| TestisIntersitial | 4.9 | |
| TestisLeydigCell | 5 | |
| TestisSeminiferousTubule | 4.25 | |
| Thalamus | 4.45 | |
| Thymus | 4.05 | |
| Thyroid | 6.55 | |
| Tongue | 5.95 | |
| Tonsil | 4.8 | |
| Trachea | 4.2 | |
| TrigeminalGanglion | 4.35 | |
| Uterus | 3.7 | |
| UterusCorpus | 3.65 | |
| WholeBlood | 4.85 | |
| Wholebrain | 3.5 | |
| colon | 4.35 | |
| pineal_day | 5.3 | |
| pineal_night | 5.38 | |
| retina | 5.975 | |
| small_intestine | 4.2 | |
- Probe name: A_24_P918384
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.92 ± 1.02 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.35 ± 0.32 | |
| Basal Part of Pons | 2.18 ± 0.34 | |
| Cerebellar Cortex | 2.8 ± 0.57 | |
| Cerebellar Nuclei | 2.73 ± 0.89 | |
| Claustrum | 3.2 ± 0.94 | |
| Epithalamus | 2.12 ± 0.89 | |
| Frontal Lobe | 2.39 ± 0.73 | |
| Globus Pallidus | 2.71 ± 0.74 | |
| Hypothalamus | 2.39 ± 0.74 | |
| Insula | 2.25 ± 0.58 | |
| Limbic Lobe | 2.47 ± 0.64 | |
| Mesencephalon | 2.63 ± 0.67 | |
| Myelencephalon | 2.52 ± 0.68 | |
| Occipital Lobe | 2.6 ± 0.89 | |
| Parietal Lobe | 2.59 ± 0.78 | |
| Pontine Tegmentum | 2.59 ± 0.82 | |
| Striatum | 2.47 ± 0.74 | |
| Subthalamus | 2.58 ± 0.73 | |
| Temporal Lobe | 2.34 ± 0.67 | |
| Thalamus | 2.46 ± 0.61 | |
| White Matter | 3.09 ± 0.71 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Nsd1 | CB | Cerebellum | 22.5 | |
| 26.12 | | |||
| Nsd1 | CTX | Cerebral cortex | 33.39 | |
| 25.68 | | |||
| Nsd1 | HPF | Hippocampal formation | 37.77 | |
| 37.73 | | |||
| Nsd1 | LSX | Lateral septal complex | 9.39 | |
| 7.53 | | |||
| Nsd1 | MB | Midbrain | 6.8 | |
| 6.47 | | |||
| Nsd1 | MY | Medulla | 22.32 | |
| 23.98 | | |||
| Nsd1 | PAL | Pallidum | 9.74 | |
| 8.69 | | |||
| Nsd1 | RHP | Retrohippocampal region | 45.47 | |
| 36.46 | | |||
| Nsd1 | sAMY | Striatum-like amygdalar nuclei | 19.1 | |
| 13.75 | | |||
| Nsd1 | STRd | Striatum dorsal region | 12.78 | |
| 10.27 | | |||
| Nsd1 | TH | Thalamus | 13.66 | |
| 11.09 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| NSD1_HUMAN_2 | 9 | 2 | 10 | DQTCELPRR | PRIDE |