AutismKB 2.0

Annotation Detail for XPO4


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Basic Information Top
Gene Symbol:XPO4 ( FLJ13046,KIAA1721 )
Gene Full Name: exportin 4
Band: 13q12.11
Quick LinksEntrez ID:64328; OMIM: 611449; Uniprot ID:XPO4_HUMAN; ENSEMBL ID: ENSG00000132953; HGNC ID: 17796
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult4 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal10 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218479_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.55
Adipocyte4
AdrenalCortex4.25
Adrenalgland3.4
Amygdala4.2
Appendix4.1
AtrioventricularNode3.15
BDCA4+_DentriticCells4.6
Bonemarrow4
BronchialEpithelialCells4.15
CD105+_Endothelial4.95
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid5.15
CD34+5.15
CD4+_Tcells4.35
CD56+_NKCells4.85
CD71+_EarlyErythroid3.9
CD8+_Tcells4
CardiacMyocytes6.1
Caudatenucleus3.6
Cerebellum3.25
CerebellumPeduncles4.65
CiliaryGanglion2.9
CingulateCortex4.1
Colorectaladenocarcinoma4.1
DorsalRootGanglion3.1
FetalThyroid4
Fetalbrain4
Fetalliver3.55
Fetallung3.3
GlobusPallidus2.95
Heart5.2
Hypothalamus4.4
Kidney3.3
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.6
Leukemialymphoblastic(MOLT-4)3.25
Liver5.35
Lung4.4
Lymphnode3.5
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)5.7
MedullaOblongata3.7
OccipitalLobe3.65
OlfactoryBulb3.2
Ovary2.7
Pancreas5.25
PancreaticIslet4.35
ParietalLobe4.3
Pituitary4.75
Placenta4.2
Pons3.9
PrefrontalCortex5.05
Prostate4.7
Salivarygland3.2
SkeletalMuscle4.85
Skin3.15
SmoothMuscle4.75
Spinalcord4.25
SubthalamicNucleus3.7
SuperiorCervicalGanglion4.7
TemporalLobe3.7
Testis3.5
TestisGermCell5.75
TestisIntersitial3.65
TestisLeydigCell5.95
TestisSeminiferousTubule5
Thalamus4.15
Thymus3.2
Thyroid5.05
Tongue4
Tonsil3.95
Trachea3.4
TrigeminalGanglion4.15
Uterus3.25
UterusCorpus4.8
WholeBlood4.45
Wholebrain3.35
colon4.05
pineal_day32
pineal_night13.34
retina4.875
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P139983
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.71 ± 0.43
Basal Forebrain5.72 ± 0.3
Basal Part of Pons5.64 ± 0.26
Cerebellar Cortex5.99 ± 0.21
Cerebellar Nuclei5.86 ± 0.37
Claustrum5.78 ± 0.59
Epithalamus6 ± 0.29
Frontal Lobe5.62 ± 0.37
Globus Pallidus5.95 ± 0.32
Hypothalamus5.8 ± 0.33
Insula5.42 ± 0.27
Limbic Lobe5.69 ± 0.38
Mesencephalon5.83 ± 0.44
Myelencephalon5.7 ± 0.38
Occipital Lobe5.98 ± 0.29
Parietal Lobe5.76 ± 0.34
Pontine Tegmentum5.72 ± 0.38
Striatum5.54 ± 0.39
Subthalamus5.88 ± 0.11
Temporal Lobe5.65 ± 0.36
Thalamus5.72 ± 0.29
White Matter6.62 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Xpo4CBCerebellum3.3
4.36
Xpo4CTXCerebral cortex1.28
1.02
Xpo4HIPHippocampal region2.66
2.47
Xpo4HPFHippocampal formation1.9
1.81
Xpo4HYHypothalamus0.52
0.39
Xpo4LSXLateral septal complex0.32
0.22
Xpo4MBMidbrain1.85
1.83
Xpo4MYMedulla3.34
3.31
Xpo4OLFOlfactory bulb1.4
1.01
Xpo4PPons2.32
2.4
Xpo4PALPallidum0.48
0.32
Xpo4RHPRetrohippocampal region0.76
0.98
Xpo4sAMYStriatum-like amygdalar nuclei0.29
0.26
Xpo4STRStriatum0.44
0.41
Xpo4STRdStriatum dorsal region0.5
0.56
Xpo4STRvStriatum ventral region0.4
0.21
Xpo4THThalamus1.99
1.53
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069737 17 514 530 HQQQLLASPGSSTVDNK Peptide Atlas
XPO4_HUMAN_274 10 274 283 VMELFFTVHR PRIDE
XPO4_HUMAN_35 11 35 45 QHAEHIFLSFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018