Annotation Detail for ITSN1
Basic Information Top
| Gene Symbol: | ITSN1 ( ITSN,MGC134948,MGC134949,SH3D1A,SH3P17 ) |
|---|---|
| Gene Full Name: | intersectin 1 (SH3 domain protein) |
| Band: | 21q22.11 |
| Quick Links | Entrez ID:6453; OMIM: 602442; Uniprot ID:ITSN1_HUMAN; ENSEMBL ID: ENSG00000205726; HGNC ID: 6183 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.160324
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 7 / 70761 | 98 |  |
| blastocyst | 8 / 62319 | 128 | |
| fetus | 69 / 564012 | 122 | |
| neonate | 2 / 31097 | 64 | |
| infant | 1 / 23620 | 42 |  |
| juvenile | 7 / 55556 | 125 | |
| adult | 104 / 1939121 | 53 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 2 / 34366 | 58 | |
| chondrosarcoma | 4 / 82823 | 48 | |
| colorectal tumor | 7 / 114246 | 61 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 2 / 119369 | 16 | |
| germ cell tumor | 16 / 263845 | 60 | |
| glioma | 4 / 106883 | 37 | |
| head and neck tumor | 1 / 136302 | 7 |  |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 4 / 95842 | 41 | |
| liver tumor | 7 / 96359 | 72 | |
| lung tumor | 3 / 103127 | 29 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 207 / 3360307 | 61 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 3 / 46356 | 64 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 5 / 125191 | 39 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 0 / 29757 | 0 | |
| blood | 2 / 123478 | 16 | |
| bone | 7 / 71655 | 97 | |
| bone marrow | 2 / 48801 | 40 | |
| brain | 57 / 1100989 | 51 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 5 / 149255 | 33 | |
| ear | 3 / 16212 | 185 | |
| embryonic tissue | 25 / 215722 | 115 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 16 / 211054 | 75 | |
| heart | 12 / 89626 | 133 | |
| intestine | 8 / 234472 | 34 | |
| kidney | 6 / 211777 | 28 | |
| larynx | 0 / 24145 | 0 | |
| liver | 16 / 207743 | 77 | |
| lung | 10 / 336974 | 29 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 1 / 91610 | 10 | |
| mammary gland | 11 / 153271 | 71 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 6 / 107715 | 55 | |
| nerve | 3 / 15768 | 190 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 5 / 214812 | 23 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 13 / 280825 | 46 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 5 / 210574 | 23 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 1 / 96619 | 10 | |
| testis | 9 / 330442 | 27 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 2 / 13680 | 146 | |
| uterus | 17 / 232878 | 72 | |
| vascular | 8 / 51780 | 154 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 207322_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6 | |
| Adipocyte | 4.75 | |
| AdrenalCortex | 5.4 | |
| Adrenalgland | 4.25 | |
| Amygdala | 5.05 | |
| Appendix | 5.6 | |
| AtrioventricularNode | 4.75 | |
| BDCA4+_DentriticCells | 5.25 | |
| Bonemarrow | 5 | |
| BronchialEpithelialCells | 4.75 | |
| CD105+_Endothelial | 4.9 | |
| CD14+_Monocytes | 5.2 | |
| CD19+_BCells(neg._sel.) | 5.25 | |
| CD33+_Myeloid | 6.1 | |
| CD34+ | 5.95 | |
| CD4+_Tcells | 5.1 | |
| CD56+_NKCells | 5.6 | |
| CD71+_EarlyErythroid | 4.65 | |
| CD8+_Tcells | 4.5 | |
| CardiacMyocytes | 6.7 | |
| Caudatenucleus | 4.45 | |
| Cerebellum | 3.95 | |
| CerebellumPeduncles | 5.7 | |
| CiliaryGanglion | 3.7 | |
| CingulateCortex | 5.1 | |
| Colorectaladenocarcinoma | 4.95 | |
| DorsalRootGanglion | 4.05 | |
| FetalThyroid | 4.85 | |
| Fetalbrain | 4.9 | |
| Fetalliver | 4.35 | |
| Fetallung | 3.9 | |
| GlobusPallidus | 3.7 | |
| Heart | 7.55 | |
| Hypothalamus | 5.3 | |
| Kidney | 4.2 | |
| Leukemia_chronicMyelogenousK-562 | 4.4 | |
| Leukemia_promyelocytic-HL-60 | 4.35 | |
| Leukemialymphoblastic(MOLT-4) | 3.9 | |
| Liver | 7.15 | |
| Lung | 5.4 | |
| Lymphnode | 4.2 | |
| Lymphoma_burkitts(Daudi) | 6.4 | |
| Lymphoma_burkitts(Raji) | 7.2 | |
| MedullaOblongata | 4.45 | |
| OccipitalLobe | 4.4 | |
| OlfactoryBulb | 3.85 | |
| Ovary | 3.75 | |
| Pancreas | 4 | |
| PancreaticIslet | 5.3 | |
| ParietalLobe | 5.3 | |
| Pituitary | 5.8 | |
| Placenta | 5.05 | |
| Pons | 4.7 | |
| PrefrontalCortex | 6.05 | |
| Prostate | 5.75 | |
| Salivarygland | 4 | |
| SkeletalMuscle | 6.25 | |
| Skin | 4.4 | |
| SmoothMuscle | 5.45 | |
| Spinalcord | 5.25 | |
| SubthalamicNucleus | 4.55 | |
| SuperiorCervicalGanglion | 7.15 | |
| TemporalLobe | 4.6 | |
| Testis | 4.15 | |
| TestisGermCell | 3.9 | |
| TestisIntersitial | 4.15 | |
| TestisLeydigCell | 5.05 | |
| TestisSeminiferousTubule | 4.2 | |
| Thalamus | 5.05 | |
| Thymus | 3.85 | |
| Thyroid | 6.1 | |
| Tongue | 5 | |
| Tonsil | 4.8 | |
| Trachea | 4.1 | |
| TrigeminalGanglion | 6.35 | |
| Uterus | 3.95 | |
| UterusCorpus | 4.5 | |
| WholeBlood | 5.35 | |
| Wholebrain | 4.1 | |
| colon | 4.95 | |
| pineal_day | 5.98 | |
| pineal_night | 5.98 | |
| retina | 5.95 | |
| small_intestine | 4.7 | |
- Probe name: CUST_16322_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 8 ± 0.23 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.87 ± 0.19 | |
| Basal Part of Pons | 8.05 ± 0.21 | |
| Cerebellar Cortex | 8.02 ± 0.14 | |
| Cerebellar Nuclei | 7.92 ± 0.26 | |
| Claustrum | 7.74 ± 0.27 | |
| Epithalamus | 8.08 ± 0.32 | |
| Frontal Lobe | 7.98 ± 0.28 | |
| Globus Pallidus | 7.48 ± 0.29 | |
| Hypothalamus | 7.84 ± 0.2 | |
| Insula | 8.02 ± 0.2 | |
| Limbic Lobe | 7.89 ± 0.21 | |
| Mesencephalon | 7.91 ± 0.33 | |
| Myelencephalon | 7.92 ± 0.28 | |
| Occipital Lobe | 7.94 ± 0.23 | |
| Parietal Lobe | 8.04 ± 0.24 | |
| Pontine Tegmentum | 7.93 ± 0.19 | |
| Striatum | 7.75 ± 0.25 | |
| Subthalamus | 8.08 ± 0.15 | |
| Temporal Lobe | 7.96 ± 0.2 | |
| Thalamus | 8 ± 0.29 | |
| White Matter | 6.8 ± 0.11 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Itsn1 | CB | Cerebellum | 92.29 | |
| 60.85 | | |||
| Itsn1 | CTX | Cerebral cortex | 97.75 | |
| 67.51 | | |||
| Itsn1 | HIP | Hippocampal region | 86.17 | |
| 95.69 | | |||
| Itsn1 | HPF | Hippocampal formation | 97.67 | |
| 95.59 | | |||
| Itsn1 | HY | Hypothalamus | 100 | |
| 77.25 | | |||
| Itsn1 | LSX | Lateral septal complex | 75.31 | |
| 44.12 | | |||
| Itsn1 | MB | Midbrain | 89.53 | |
| 74.31 | | |||
| Itsn1 | MY | Medulla | 85.03 | |
| 90.22 | | |||
| Itsn1 | OLF | Olfactory bulb | 100 | |
| 85.12 | | |||
| Itsn1 | P | Pons | 81.84 | |
| 86.43 | | |||
| Itsn1 | PAL | Pallidum | 76.5 | |
| 66.68 | | |||
| Itsn1 | RHP | Retrohippocampal region | 100 | |
| 93.14 | | |||
| Itsn1 | sAMY | Striatum-like amygdalar nuclei | 100 | |
| 64.97 | | |||
| Itsn1 | STR | Striatum | 50.18 | |
| 30.05 | | |||
| Itsn1 | STRd | Striatum dorsal region | 30.91 | |
| 18.56 | | |||
| Itsn1 | STRv | Striatum ventral region | 78.34 | |
| 42.45 | | |||
| Itsn1 | TH | Thalamus | 100 | |
| 92.95 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00504655 | 23 | 804 | 826 | IPENEVPAPVKPVTDSTSAPAPK | Peptide Atlas |