AutismKB 2.0

Annotation Detail for SHB


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Basic Information Top
Gene Symbol:SHB ( RP11-3J10.8,bA3J10.2 )
Gene Full Name: Src homology 2 domain containing adaptor protein B
Band: 9p13.1
Quick LinksEntrez ID:6461; OMIM: 600314; Uniprot ID:SHB_HUMAN; ENSEMBL ID: ENSG00000107338; HGNC ID: 10838
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult71 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor39 / 263845147
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal66 / 336030719
ovarian tumor19 / 76682247
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain14 / 110098912
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye12 / 21105456
heart2 / 8962622
intestine6 / 23447225
kidney13 / 21177761
larynx0 / 241450 
liver3 / 20774314
lung19 / 33697456
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary20 / 102051195
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta3 / 28082510
prostate1 / 1893455
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204657_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.8
Adipocyte3.7
AdrenalCortex3.95
Adrenalgland3.05
Amygdala3.9
Appendix3.7
AtrioventricularNode2.85
BDCA4+_DentriticCells3.95
Bonemarrow3.65
BronchialEpithelialCells4
CD105+_Endothelial3.8
CD14+_Monocytes3.9
CD19+_BCells(neg._sel.)3.9
CD33+_Myeloid4.5
CD34+4.7
CD4+_Tcells4.05
CD56+_NKCells4.05
CD71+_EarlyErythroid3.45
CD8+_Tcells3.5
CardiacMyocytes7.55
Caudatenucleus4.1
Cerebellum3.05
CerebellumPeduncles4.2
CiliaryGanglion2.65
CingulateCortex3.85
Colorectaladenocarcinoma8.95
DorsalRootGanglion2.8
FetalThyroid3.55
Fetalbrain3.8
Fetalliver3.15
Fetallung3.1
GlobusPallidus2.7
Heart4.8
Hypothalamus4.1
Kidney3.15
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.25
Leukemialymphoblastic(MOLT-4)3
Liver5.45
Lung6.8
Lymphnode3.2
Lymphoma_burkitts(Daudi)4.65
Lymphoma_burkitts(Raji)5.2
MedullaOblongata3.45
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.45
Pancreas3
PancreaticIslet4.4
ParietalLobe3.95
Pituitary4.4
Placenta3.95
Pons3.55
PrefrontalCortex4.7
Prostate4.5
Salivarygland3
SkeletalMuscle4.3
Skin3.35
SmoothMuscle7.15
Spinalcord4
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.2
TemporalLobe3.4
Testis3.3
TestisGermCell3.2
TestisIntersitial3.15
TestisLeydigCell3.7
TestisSeminiferousTubule3.25
Thalamus3.8
Thymus2.9
Thyroid4.85
Tongue3.7
Tonsil3.6
Trachea3.15
TrigeminalGanglion3.6
Uterus3.1
UterusCorpus3.65
WholeBlood4.05
Wholebrain3.3
colon3.85
pineal_day4.7
pineal_night4.74
retina4.6
small_intestine3.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P257743
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.77 ± 0.8
Basal Forebrain5.56 ± 0.38
Basal Part of Pons4.85 ± 0.38
Cerebellar Cortex4.37 ± 0.42
Cerebellar Nuclei5.71 ± 0.37
Claustrum6.08 ± 0.45
Epithalamus4.87 ± 0.7
Frontal Lobe5.03 ± 0.64
Globus Pallidus5.79 ± 0.44
Hypothalamus5.27 ± 0.4
Insula4.92 ± 0.39
Limbic Lobe4.78 ± 0.7
Mesencephalon5.29 ± 0.65
Myelencephalon5.18 ± 0.68
Occipital Lobe5.06 ± 0.74
Parietal Lobe5.03 ± 0.54
Pontine Tegmentum5.17 ± 0.61
Striatum6.12 ± 0.41
Subthalamus5.05 ± 0.13
Temporal Lobe4.91 ± 0.61
Thalamus5.3 ± 0.42
White Matter6.72 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ShbCBCerebellum15.64
19.91
ShbCTXCerebral cortex22.35
16.94
ShbHIPHippocampal region16.04
18.07
ShbHPFHippocampal formation22.95
23.53
ShbHYHypothalamus8.83
7.22
ShbLSXLateral septal complex12.47
9.4
ShbMBMidbrain10.77
10.04
ShbMYMedulla19.44
24.54
ShbOLFOlfactory bulb34.37
30.99
ShbPPons15.61
18.57
ShbPALPallidum13.89
12.72
ShbRHPRetrohippocampal region32.43
29.14
ShbsAMYStriatum-like amygdalar nuclei11.14
8.91
ShbSTRStriatum51.4
39.76
ShbSTRdStriatum dorsal region69.67
54.92
ShbSTRvStriatum ventral region31.53
22.93
ShbTHThalamus24.13
19.87
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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