AutismKB 2.0

Annotation Detail for UNKL


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Basic Information Top
Gene Symbol:UNKL ( C16orf28,FLJ12623,FLJ23360,KIAA0734,MGC5179,ZC3H5L,ZC3HDC5L )
Gene Full Name: unkempt homolog (Drosophila)-like
Band: 16p13.3
Quick LinksEntrez ID:64718; OMIM: NA; Uniprot ID:UNKL_HUMAN; ENSEMBL ID: ENSG00000059145; HGNC ID: 14184
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus13 / 56401223
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor17 / 26384564
glioma5 / 10688346
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal80 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye6 / 21105428
heart4 / 8962644
intestine1 / 2344724
kidney7 / 21177733
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph0 / 442700 
lymph node5 / 9161054
mammary gland5 / 15327132
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta9 / 28082532
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach2 / 9661920
testis11 / 33044233
thymus1 / 8113112
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord1 / 1368073
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221064_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.15
Adipocyte5.15
AdrenalCortex7.35
Adrenalgland4.9
Amygdala6.2
Appendix6.35
AtrioventricularNode5.35
BDCA4+_DentriticCells5.4
Bonemarrow5.8
BronchialEpithelialCells5
CD105+_Endothelial5.6
CD14+_Monocytes6.05
CD19+_BCells(neg._sel.)6
CD33+_Myeloid6.7
CD34+6.8
CD4+_Tcells5.6
CD56+_NKCells6.25
CD71+_EarlyErythroid5.15
CD8+_Tcells5.5
CardiacMyocytes7.1
Caudatenucleus5
Cerebellum4.5
CerebellumPeduncles6.75
CiliaryGanglion5.2
CingulateCortex6.75
Colorectaladenocarcinoma5.35
DorsalRootGanglion4.7
FetalThyroid7.95
Fetalbrain6.75
Fetalliver4.65
Fetallung4.4
GlobusPallidus4.95
Heart7.3
Hypothalamus6.3
Kidney4.5
Leukemia_chronicMyelogenousK-5624.85
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)4.35
Liver7.4
Lung8.2
Lymphnode4.6
Lymphoma_burkitts(Daudi)6.95
Lymphoma_burkitts(Raji)8.85
MedullaOblongata4.9
OccipitalLobe5
OlfactoryBulb4.55
Ovary3.65
Pancreas4.45
PancreaticIslet5.75
ParietalLobe6.75
Pituitary6.5
Placenta5.45
Pons5.65
PrefrontalCortex6.9
Prostate6.55
Salivarygland4.65
SkeletalMuscle8.8
Skin4.3
SmoothMuscle6.2
Spinalcord5.9
SubthalamicNucleus5.05
SuperiorCervicalGanglion6.55
TemporalLobe5.4
Testis4.5
TestisGermCell4.25
TestisIntersitial4.55
TestisLeydigCell5.55
TestisSeminiferousTubule4.75
Thalamus5.85
Thymus6.5
Thyroid6.75
Tongue6.2
Tonsil5.4
Trachea4.35
TrigeminalGanglion7.05
Uterus4.5
UterusCorpus4.95
WholeBlood5.95
Wholebrain4.65
colon5.3
pineal_day6.82
pineal_night6.8
retina6.8
small_intestine5.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6648_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.77 ± 1.04
Basal Forebrain2.26 ± 0.28
Basal Part of Pons2.14 ± 0.49
Cerebellar Cortex2.96 ± 0.59
Cerebellar Nuclei2.61 ± 0.66
Claustrum3.16 ± 0.92
Epithalamus2.04 ± 0.77
Frontal Lobe2.18 ± 0.66
Globus Pallidus2.5 ± 0.98
Hypothalamus2.29 ± 0.76
Insula2.62 ± 1.7
Limbic Lobe2.45 ± 0.74
Mesencephalon2.48 ± 0.74
Myelencephalon2.41 ± 0.68
Occipital Lobe2.3 ± 0.8
Parietal Lobe2.29 ± 0.78
Pontine Tegmentum2.43 ± 0.81
Striatum2.05 ± 0.6
Subthalamus2.42 ± 0.7
Temporal Lobe2.41 ± 0.73
Thalamus2.36 ± 0.67
White Matter2.61 ± 0.79
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
UnklCBCerebellum22.42
23.02
UnklCTXCerebral cortex49.83
35.3
UnklHIPHippocampal region35.27
46.52
UnklHPFHippocampal formation37.36
40.8
UnklHYHypothalamus26.86
21.08
UnklLSXLateral septal complex27.25
18.57
UnklMBMidbrain38.87
33.52
UnklMYMedulla25.03
24.68
UnklOLFOlfactory bulb29.79
23.23
UnklPPons39.43
38.98
UnklPALPallidum25.24
20.75
UnklRHPRetrohippocampal region41.64
33.63
UnklsAMYStriatum-like amygdalar nuclei17.61
12.44
UnklSTRStriatum25.51
17.41
UnklSTRdStriatum dorsal region24.31
16.79
UnklSTRvStriatum ventral region32.33
20.71
UnklTHThalamus52.82
44.59
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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