AutismKB 2.0

Annotation Detail for CERK


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Basic Information Top
Gene Symbol:CERK ( DKFZp434E0211,FLJ21430,FLJ23239,KIAA1646,LK4,MGC131878,dA59H18.2,dA59H18.3,hCERK )
Gene Full Name: ceramide kinase
Band: 22q13.31
Quick LinksEntrez ID:64781; OMIM: 610307; Uniprot ID:CERK1_HUMAN; ENSEMBL ID: ENSG00000100422; HGNC ID: 19256
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus29 / 56401251
neonate2 / 3109764
infant1 / 2362042
juvenile6 / 55556107
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor18 / 26384568
glioma1 / 1068839
head and neck tumor8 / 13630258
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor7 / 9635972
lung tumor1 / 1031279
lymphoma8 / 71755111
non-neoplasia1 / 9725010
normal152 / 336030745
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma4 / 4635686
skin tumor3 / 12494924
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood3 / 12347824
bone1 / 7165513
bone marrow1 / 4880120
brain58 / 110098952
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye15 / 21105471
heart10 / 89626111
intestine11 / 23447246
kidney3 / 21177714
larynx1 / 2414541
liver11 / 20774352
lung10 / 33697429
lymph4 / 4427090
lymph node16 / 91610174
mammary gland3 / 15327119
mouth3 / 6705244
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas7 / 21481232
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin11 / 21057452
spleen1 / 5395218
stomach3 / 9661931
testis15 / 33044245
thymus7 / 8113186
thyroid5 / 47473105
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord2 / 13680146
uterus6 / 23287825
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218421_at
Cell line Expression level Expression bar
721_B_lymphoblasts33.05
Adipocyte3.85
AdrenalCortex4.05
Adrenalgland4.7
Amygdala4.4
Appendix3.75
AtrioventricularNode2.8
BDCA4+_DentriticCells96.15
Bonemarrow3.65
BronchialEpithelialCells3.8
CD105+_Endothelial3.85
CD14+_Monocytes32
CD19+_BCells(neg._sel.)21.15
CD33+_Myeloid65.95
CD34+62.9
CD4+_Tcells123.4
CD56+_NKCells104.55
CD71+_EarlyErythroid3.55
CD8+_Tcells107.6
CardiacMyocytes5
Caudatenucleus3.4
Cerebellum25.95
CerebellumPeduncles13.6
CiliaryGanglion2.6
CingulateCortex4.45
Colorectaladenocarcinoma3.8
DorsalRootGanglion2.85
FetalThyroid3.7
Fetalbrain7.2
Fetalliver3.25
Fetallung3.25
GlobusPallidus2.75
Heart7.95
Hypothalamus11.1
Kidney3
Leukemia_chronicMyelogenousK-5623.4
Leukemia_promyelocytic-HL-603.35
Leukemialymphoblastic(MOLT-4)6.85
Liver4.9
Lung4.25
Lymphnode3.4
Lymphoma_burkitts(Daudi)10.65
Lymphoma_burkitts(Raji)5.2
MedullaOblongata3.5
OccipitalLobe3.85
OlfactoryBulb3.05
Ovary2.45
Pancreas3.3
PancreaticIslet13.2
ParietalLobe3.95
Pituitary47
Placenta4
Pons3.55
PrefrontalCortex7.25
Prostate4.4
Salivarygland3.55
SkeletalMuscle4.15
Skin2.85
SmoothMuscle4.3
Spinalcord4.25
SubthalamicNucleus3.45
SuperiorCervicalGanglion4.2
TemporalLobe3.5
Testis3.3
TestisGermCell3.2
TestisIntersitial3.15
TestisLeydigCell3.7
TestisSeminiferousTubule3.15
Thalamus5.9
Thymus27.55
Thyroid4.9
Tongue3.65
Tonsil4.8
Trachea3.2
TrigeminalGanglion3.7
Uterus3.75
UterusCorpus3.35
WholeBlood20.45
Wholebrain20.6
colon3.7
pineal_day38.02
pineal_night45.18
retina13
small_intestine21.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P211659
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.06 ± 0.29
Basal Forebrain8.31 ± 0.55
Basal Part of Pons8.48 ± 0.35
Cerebellar Cortex8.58 ± 0.27
Cerebellar Nuclei9.21 ± 0.35
Claustrum8.08 ± 0.51
Epithalamus7.88 ± 0.42
Frontal Lobe8.24 ± 0.46
Globus Pallidus9.14 ± 0.33
Hypothalamus8.23 ± 0.41
Insula7.99 ± 0.45
Limbic Lobe8.38 ± 0.49
Mesencephalon8.62 ± 0.56
Myelencephalon8.34 ± 0.45
Occipital Lobe8.87 ± 0.5
Parietal Lobe8.48 ± 0.39
Pontine Tegmentum8.29 ± 0.46
Striatum7.85 ± 0.43
Subthalamus8.58 ± 0.37
Temporal Lobe8.13 ± 0.44
Thalamus8.36 ± 0.41
White Matter6.95 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CerkCBCerebellum25.31
100
CerkCTXCerebral cortex15.89
14.54
CerkHIPHippocampal region8.23
9.96
CerkHPFHippocampal formation11.2
11.73
CerkHYHypothalamus3.69
3.33
CerkLSXLateral septal complex1.94
1.66
CerkMBMidbrain13.38
16.1
CerkMYMedulla35.33
50.29
CerkOLFOlfactory bulb16.6
16.72
CerkPPons22.14
30.08
CerkPALPallidum15.79
20.18
CerkRHPRetrohippocampal region15.93
14.11
CerksAMYStriatum-like amygdalar nuclei3.44
3.43
CerkSTRStriatum3.39
3.31
CerkSTRdStriatum dorsal region3.36
3.23
CerkSTRvStriatum ventral region4.13
4.15
CerkTHThalamus14.69
14.11
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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