AutismKB 2.0

Annotation Detail for KLC2


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Basic Information Top
Gene Symbol:KLC2 ( FLJ12387 )
Gene Full Name: kinesin light chain 2
Band: 11q13.2
Quick LinksEntrez ID:64837; OMIM: 611729; Uniprot ID:KLC2_HUMAN; ENSEMBL ID: ENSG00000174996; HGNC ID: 20716
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult77 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor6 / 26384522
glioma7 / 10688365
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor9 / 10312787
lymphoma5 / 7175569
non-neoplasia5 / 9725051
normal124 / 336030736
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer10 / 10268097
retinoblastoma5 / 46356107
skin tumor5 / 12494940
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood5 / 12347840
bone0 / 716550 
bone marrow0 / 488010 
brain69 / 110098962
cervix6 / 48171124
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye18 / 21105485
heart1 / 8962611
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver2 / 2077439
lung16 / 33697447
lymph5 / 44270112
lymph node1 / 9161010
mammary gland6 / 15327139
mouth3 / 6705244
muscle2 / 10771518
nerve2 / 15768126
ovary0 / 1020510 
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate10 / 18934552
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach6 / 9661962
testis9 / 33044227
thymus11 / 81131135
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218906_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts24
Adipocyte16.6
AdrenalCortex24.95
Adrenalgland31.7
Amygdala328.65
Appendix21.4
AtrioventricularNode19.35
BDCA4+_DentriticCells19.8
Bonemarrow23.2
BronchialEpithelialCells25
CD105+_Endothelial12.4
CD14+_Monocytes13.9
CD19+_BCells(neg._sel.)20.4
CD33+_Myeloid14.15
CD34+16.25
CD4+_Tcells24.7
CD56+_NKCells15.7
CD71+_EarlyErythroid13.45
CD8+_Tcells23.05
CardiacMyocytes25.35
Caudatenucleus76
Cerebellum279.85
CerebellumPeduncles163.15
CiliaryGanglion17.85
CingulateCortex97.65
Colorectaladenocarcinoma29.85
DorsalRootGanglion16.1
FetalThyroid25.45
Fetalbrain44.75
Fetalliver14.6
Fetallung20.6
GlobusPallidus32.9
Heart41.35
Hypothalamus50.65
Kidney24.5
Leukemia_chronicMyelogenousK-56216.85
Leukemia_promyelocytic-HL-6025.05
Leukemialymphoblastic(MOLT-4)24.1
Liver32.9
Lung59.9
Lymphnode17.5
Lymphoma_burkitts(Daudi)27.95
Lymphoma_burkitts(Raji)67.6
MedullaOblongata93.15
OccipitalLobe49.2
OlfactoryBulb18.45
Ovary17.1
Pancreas16.65
PancreaticIslet25.1
ParietalLobe75.15
Pituitary56.2
Placenta28.65
Pons56.7
PrefrontalCortex748.2
Prostate65.4
Salivarygland19.75
SkeletalMuscle28.8
Skin19.3
SmoothMuscle28.15
Spinalcord59.5
SubthalamicNucleus48.15
SuperiorCervicalGanglion27.95
TemporalLobe65.85
Testis54.2
TestisGermCell24.85
TestisIntersitial17.8
TestisLeydigCell23.05
TestisSeminiferousTubule21.7
Thalamus68.1
Thymus30.75
Thyroid33.85
Tongue25.15
Tonsil23.85
Trachea21.85
TrigeminalGanglion25.1
Uterus20.4
UterusCorpus14.85
WholeBlood16.55
Wholebrain323.85
colon13.4
pineal_day59.92
pineal_night33.48
retina28.575
small_intestine11.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P227211
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.73 ± 0.5
Basal Forebrain4.87 ± 0.46
Basal Part of Pons5.48 ± 0.26
Cerebellar Cortex5.41 ± 0.3
Cerebellar Nuclei5.09 ± 0.35
Claustrum4.85 ± 0.39
Epithalamus4.52 ± 0.2
Frontal Lobe5.17 ± 0.48
Globus Pallidus4.2 ± 0.45
Hypothalamus4.76 ± 0.76
Insula5 ± 0.49
Limbic Lobe5.1 ± 0.44
Mesencephalon4.92 ± 0.46
Myelencephalon5.02 ± 0.51
Occipital Lobe4.95 ± 0.4
Parietal Lobe5.07 ± 0.4
Pontine Tegmentum4.81 ± 0.48
Striatum4.47 ± 0.39
Subthalamus4.79 ± 0.51
Temporal Lobe5.08 ± 0.39
Thalamus5.02 ± 0.44
White Matter4.08 ± 0.66
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KLC2_HUMAN_135 10 135 144 QHLLFMSQIR PRIDE
KLC2_HUMAN_2 7 2 8 AMMVFPR PRIDE
KLC2_HUMAN_462 16 462 477 QGKLEAAHTLEDCASR PRIDE
PAp00007801 11 368 378 TKNNLASCYLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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