AutismKB 2.0

Annotation Detail for FNDC4


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Basic Information Top
Gene Symbol:FNDC4 ( FLJ22362,FRCP1 )
Gene Full Name: fibronectin type III domain containing 4
Band: 2p23.3
Quick LinksEntrez ID:64838; OMIM: 611905; Uniprot ID:FNDC4_HUMAN; ENSEMBL ID: ENSG00000115226; HGNC ID: 20239
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218843_at
Cell line Expression level Expression bar
721_B_lymphoblasts7
Adipocyte38.05
AdrenalCortex29.35
Adrenalgland19.8
Amygdala8.3
Appendix8
AtrioventricularNode5.9
BDCA4+_DentriticCells5.65
Bonemarrow10.6
BronchialEpithelialCells7.55
CD105+_Endothelial5.95
CD14+_Monocytes5.7
CD19+_BCells(neg._sel.)6.35
CD33+_Myeloid8.25
CD34+7.45
CD4+_Tcells6.5
CD56+_NKCells6.95
CD71+_EarlyErythroid6.05
CD8+_Tcells5.6
CardiacMyocytes9.35
Caudatenucleus12.6
Cerebellum21.65
CerebellumPeduncles13.9
CiliaryGanglion5.05
CingulateCortex38.1
Colorectaladenocarcinoma6.6
DorsalRootGanglion5.75
FetalThyroid7.35
Fetalbrain18.55
Fetalliver6.95
Fetallung6.8
GlobusPallidus11.2
Heart8.35
Hypothalamus11.35
Kidney6.1
Leukemia_chronicMyelogenousK-5628.2
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)6
Liver17.05
Lung6.4
Lymphnode5.9
Lymphoma_burkitts(Daudi)9.55
Lymphoma_burkitts(Raji)7.9
MedullaOblongata18.7
OccipitalLobe16.7
OlfactoryBulb6.05
Ovary10.9
Pancreas6.5
PancreaticIslet10.45
ParietalLobe15.15
Pituitary9.3
Placenta6.75
Pons12.65
PrefrontalCortex12.9
Prostate7.9
Salivarygland6
SkeletalMuscle8
Skin6.75
SmoothMuscle11.7
Spinalcord16
SubthalamicNucleus11.85
SuperiorCervicalGanglion14.4
TemporalLobe29.55
Testis12.7
TestisGermCell10.3
TestisIntersitial9.85
TestisLeydigCell9.75
TestisSeminiferousTubule12.7
Thalamus22.55
Thymus4.7
Thyroid7.25
Tongue6.9
Tonsil7.45
Trachea6.45
TrigeminalGanglion11.5
Uterus4.95
UterusCorpus5.75
WholeBlood7.05
Wholebrain27.25
colon5.2
pineal_day9.4
pineal_night9.12
retina9.3
small_intestine4.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9402_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.92 ± 0.39
Basal Forebrain6.61 ± 0.3
Basal Part of Pons7.63 ± 0.2
Cerebellar Cortex6.89 ± 0.45
Cerebellar Nuclei7.34 ± 0.38
Claustrum6.37 ± 0.43
Epithalamus6.05 ± 0.57
Frontal Lobe7.11 ± 0.54
Globus Pallidus6.55 ± 0.57
Hypothalamus6.13 ± 0.44
Insula6.91 ± 0.34
Limbic Lobe7.12 ± 0.72
Mesencephalon6.83 ± 0.5
Myelencephalon6.92 ± 0.59
Occipital Lobe7.18 ± 0.36
Parietal Lobe7.2 ± 0.47
Pontine Tegmentum6.79 ± 0.57
Striatum6.33 ± 0.42
Subthalamus7.5 ± 0.17
Temporal Lobe6.92 ± 0.53
Thalamus6.93 ± 0.36
White Matter4.67 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fndc4CBCerebellum52.57
100
Fndc4CTXCerebral cortex100
100
Fndc4HIPHippocampal region99.3
100
Fndc4HPFHippocampal formation100
100
Fndc4HYHypothalamus82.06
80.84
Fndc4LSXLateral septal complex76.51
73.31
Fndc4MBMidbrain93.08
97.78
Fndc4MYMedulla90.99
100
Fndc4OLFOlfactory bulb100
100
Fndc4PPons89.19
99.02
Fndc4PALPallidum75.86
84.11
Fndc4RHPRetrohippocampal region100
100
Fndc4sAMYStriatum-like amygdalar nuclei100
100
Fndc4STRStriatum84.58
78.59
Fndc4STRdStriatum dorsal region78.63
71.54
Fndc4STRvStriatum ventral region79.06
73.19
Fndc4THThalamus100
100
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018