AutismKB 2.0

Annotation Detail for SIPA1


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Basic Information Top
Gene Symbol:SIPA1 ( MGC102688,MGC17037,SPA1 )
Gene Full Name: signal-induced proliferation-associated 1
Band: 11q13.1
Quick LinksEntrez ID:6494; OMIM: 602180; Uniprot ID:SIPA1_HUMAN; ENSEMBL ID: ENSG00000213445; HGNC ID: 10885
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus12 / 56401221
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor3 / 3436687
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor11 / 26384541
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia10 / 95842104
liver tumor3 / 9635931
lung tumor4 / 10312738
lymphoma6 / 7175583
non-neoplasia3 / 9725030
normal89 / 336030726
ovarian tumor3 / 7668239
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma4 / 4635686
skin tumor6 / 12494948
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood9 / 12347872
bone0 / 716550 
bone marrow1 / 4880120
brain14 / 110098912
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye8 / 21105437
heart3 / 8962633
intestine3 / 23447212
kidney3 / 21177714
larynx0 / 241450 
liver8 / 20774338
lung11 / 33697432
lymph0 / 442700 
lymph node9 / 9161098
mammary gland1 / 1532716
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate6 / 18934531
salivary gland0 / 201550 
skin6 / 21057428
spleen4 / 5395274
stomach1 / 9661910
testis3 / 3304429
thymus4 / 8113149
thyroid1 / 4747321
tonsil8 / 16999470
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204164_at
Cell line Expression level Expression bar
721_B_lymphoblasts54.35
Adipocyte4.75
AdrenalCortex5.2
Adrenalgland4
Amygdala5.05
Appendix4.75
AtrioventricularNode3.55
BDCA4+_DentriticCells22.7
Bonemarrow5.8
BronchialEpithelialCells4.5
CD105+_Endothelial7.95
CD14+_Monocytes80.25
CD19+_BCells(neg._sel.)109.3
CD33+_Myeloid37.45
CD34+6.55
CD4+_Tcells52.65
CD56+_NKCells141.8
CD71+_EarlyErythroid6.95
CD8+_Tcells107.2
CardiacMyocytes5.95
Caudatenucleus4.25
Cerebellum3.85
CerebellumPeduncles5.35
CiliaryGanglion3.3
CingulateCortex4.85
Colorectaladenocarcinoma4.85
DorsalRootGanglion3.6
FetalThyroid4.65
Fetalbrain4.85
Fetalliver4.1
Fetallung4
GlobusPallidus3.45
Heart8.15
Hypothalamus5.25
Kidney3.8
Leukemia_chronicMyelogenousK-5624.35
Leukemia_promyelocytic-HL-604.2
Leukemialymphoblastic(MOLT-4)3.7
Liver12.65
Lung5.4
Lymphnode8.1
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)12.5
MedullaOblongata4.45
OccipitalLobe4.2
OlfactoryBulb3.8
Ovary3.15
Pancreas3.8
PancreaticIslet4.95
ParietalLobe4.95
Pituitary5.6
Placenta5
Pons4.5
PrefrontalCortex6
Prostate5.75
Salivarygland5.05
SkeletalMuscle5.45
Skin3.6
SmoothMuscle5.45
Spinalcord5.1
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.3
TemporalLobe4.35
Testis4.05
TestisGermCell3.85
TestisIntersitial3.55
TestisLeydigCell4.65
TestisSeminiferousTubule4.1
Thalamus4.8
Thymus6.1
Thyroid6
Tongue4.6
Tonsil5.65
Trachea4
TrigeminalGanglion4.7
Uterus3.95
UterusCorpus4.55
WholeBlood92.6
Wholebrain3.85
colon4.65
pineal_day5.66
pineal_night5.72
retina5.875
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12264_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.58 ± 0.5
Basal Forebrain3.77 ± 0.39
Basal Part of Pons3.85 ± 0.64
Cerebellar Cortex3.27 ± 0.53
Cerebellar Nuclei4.17 ± 0.55
Claustrum3.06 ± 0.52
Epithalamus3.93 ± 0.85
Frontal Lobe3.71 ± 0.65
Globus Pallidus4.69 ± 0.34
Hypothalamus3.41 ± 0.61
Insula3.59 ± 0.58
Limbic Lobe3.43 ± 0.67
Mesencephalon3.81 ± 0.6
Myelencephalon3.89 ± 0.64
Occipital Lobe3.8 ± 0.67
Parietal Lobe3.64 ± 0.61
Pontine Tegmentum3.66 ± 0.69
Striatum4.57 ± 0.42
Subthalamus3.95 ± 0.43
Temporal Lobe3.74 ± 0.55
Thalamus4.1 ± 0.6
White Matter4.67 ± 0.12
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043013 15 754 768 VCVTVLPPDESGRPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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