AutismKB 2.0

Annotation Detail for SLC1A1


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Basic Information Top
Gene Symbol:SLC1A1 ( EAAC1,EAAT3 )
Gene Full Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Band: 9p24.2
Quick LinksEntrez ID:6505; OMIM: 133550; Uniprot ID:EAA3_HUMAN; ENSEMBL ID: ENSG00000106688; HGNC ID: 10939
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus12 / 56401221
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal82 / 336030724
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain27 / 110098924
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine5 / 23447221
kidney20 / 21177794
larynx0 / 241450 
liver7 / 20774333
lung3 / 3369748
lymph0 / 442700 
lymph node9 / 9161098
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213664_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.5
Adipocyte7.3
AdrenalCortex7.7
Adrenalgland6.2
Amygdala133.75
Appendix7.35
AtrioventricularNode5.75
BDCA4+_DentriticCells6.4
Bonemarrow7.2
BronchialEpithelialCells6.25
CD105+_Endothelial7
CD14+_Monocytes7.6
CD19+_BCells(neg._sel.)7.3
CD33+_Myeloid8.7
CD34+9.25
CD4+_Tcells6.85
CD56+_NKCells7.95
CD71+_EarlyErythroid6.65
CD8+_Tcells6.65
CardiacMyocytes9.85
Caudatenucleus33.35
Cerebellum8.7
CerebellumPeduncles8.65
CiliaryGanglion5.65
CingulateCortex13.25
Colorectaladenocarcinoma6.9
DorsalRootGanglion5.65
FetalThyroid10.4
Fetalbrain124.4
Fetalliver6.15
Fetallung9.75
GlobusPallidus12.6
Heart9.55
Hypothalamus56.85
Kidney88.45
Leukemia_chronicMyelogenousK-5626.35
Leukemia_promyelocytic-HL-608.3
Leukemialymphoblastic(MOLT-4)5.3
Liver49.85
Lung8.15
Lymphnode6.3
Lymphoma_burkitts(Daudi)13.25
Lymphoma_burkitts(Raji)11.65
MedullaOblongata18.2
OccipitalLobe65.05
OlfactoryBulb5.5
Ovary4.85
Pancreas5.8
PancreaticIslet7.85
ParietalLobe19.7
Pituitary8.65
Placenta10
Pons10.5
PrefrontalCortex33.5
Prostate10.2
Salivarygland5.7
SkeletalMuscle8.6
Skin5.65
SmoothMuscle71.45
Spinalcord8.1
SubthalamicNucleus15.15
SuperiorCervicalGanglion8.3
TemporalLobe12.05
Testis5.6
TestisGermCell5.55
TestisIntersitial5.9
TestisLeydigCell8.7
TestisSeminiferousTubule6.1
Thalamus72.8
Thymus5.4
Thyroid154.35
Tongue7.2
Tonsil7.2
Trachea6.5
TrigeminalGanglion7.35
Uterus12.5
UterusCorpus6.65
WholeBlood7.3
Wholebrain78.9
colon20.95
pineal_day8.86
pineal_night8.28
retina8.9
small_intestine145
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P232252
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.31 ± 0.64
Basal Forebrain6.4 ± 0.14
Basal Part of Pons6.23 ± 0.4
Cerebellar Cortex6.02 ± 0.29
Cerebellar Nuclei6.45 ± 0.34
Claustrum6.44 ± 0.59
Epithalamus5.45 ± 0.56
Frontal Lobe6.45 ± 0.47
Globus Pallidus6.31 ± 0.44
Hypothalamus6.44 ± 0.32
Insula6.41 ± 0.38
Limbic Lobe6.86 ± 0.42
Mesencephalon6.45 ± 0.43
Myelencephalon6.47 ± 0.47
Occipital Lobe6.77 ± 0.41
Parietal Lobe6.62 ± 0.43
Pontine Tegmentum6.61 ± 0.44
Striatum7.05 ± 0.26
Subthalamus6.92 ± 0.14
Temporal Lobe6.55 ± 0.37
Thalamus6.73 ± 0.49
White Matter5.32 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc1a1CBCerebellum17.34
23.73
Slc1a1CTXCerebral cortex100
100
Slc1a1HIPHippocampal region100
100
Slc1a1HPFHippocampal formation100
100
Slc1a1HYHypothalamus68.29
66.6
Slc1a1LSXLateral septal complex100
100
Slc1a1MBMidbrain61.2
71.1
Slc1a1MYMedulla65.98
87.36
Slc1a1OLFOlfactory bulb100
100
Slc1a1PPons55.69
74.29
Slc1a1PALPallidum79.68
83.22
Slc1a1RHPRetrohippocampal region100
100
Slc1a1sAMYStriatum-like amygdalar nuclei80.29
76.67
Slc1a1STRStriatum96.39
90.13
Slc1a1STRdStriatum dorsal region98.58
91.11
Slc1a1STRvStriatum ventral region90.31
83.64
Slc1a1THThalamus94.67
97.87
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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