AutismKB 2.0

Annotation Detail for SLC1A2


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Basic Information Top
Gene Symbol:SLC1A2 ( EAAT2,GLT-1 )
Gene Full Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Band: 11p13
Quick LinksEntrez ID:6506; OMIM: 600300; Uniprot ID:EAA2_HUMAN; ENSEMBL ID: ENSG00000110436; HGNC ID: 10940
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus46 / 56401281
neonate0 / 310970 
infant7 / 23620296
juvenile2 / 5555635
adult197 / 1939121101
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor24 / 26384590
glioma5 / 10688346
head and neck tumor2 / 13630214
kidney tumor9 / 68959130
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia48 / 97250493
normal771 / 3360307229
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites8 / 40015199
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain778 / 1100989706
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine0 / 2344720 
kidney9 / 21177742
larynx2 / 2414582
liver7 / 20774333
lung0 / 3369740 
lymph0 / 442700 
lymph node2 / 9161021
mammary gland8 / 15327152
mouth0 / 670520 
muscle15 / 107715139
nerve4 / 15768253
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis13 / 33044239
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208389_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.85
Adipocyte4.6
AdrenalCortex5.6
Adrenalgland4.35
Amygdala61.6
Appendix5.1
AtrioventricularNode3.85
BDCA4+_DentriticCells4.95
Bonemarrow5.2
BronchialEpithelialCells4.85
CD105+_Endothelial4.75
CD14+_Monocytes5.25
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid5.6
CD34+5.85
CD4+_Tcells5
CD56+_NKCells5.3
CD71+_EarlyErythroid4.65
CD8+_Tcells4.7
CardiacMyocytes6.5
Caudatenucleus7.6
Cerebellum4.85
CerebellumPeduncles5.8
CiliaryGanglion5.25
CingulateCortex14.8
Colorectaladenocarcinoma4.95
DorsalRootGanglion4.9
FetalThyroid4.8
Fetalbrain6.25
Fetalliver4.3
Fetallung3.95
GlobusPallidus11.05
Heart6.8
Hypothalamus5.35
Kidney4.25
Leukemia_chronicMyelogenousK-5624.45
Leukemia_promyelocytic-HL-604.3
Leukemialymphoblastic(MOLT-4)4
Liver14.5
Lung5.15
Lymphnode4.2
Lymphoma_burkitts(Daudi)6.25
Lymphoma_burkitts(Raji)7.35
MedullaOblongata38
OccipitalLobe35.35
OlfactoryBulb3.9
Ovary3.4
Pancreas8.45
PancreaticIslet8.1
ParietalLobe22.05
Pituitary5.75
Placenta4.15
Pons27.05
PrefrontalCortex85.9
Prostate5.75
Salivarygland4.1
SkeletalMuscle6.3
Skin3.85
SmoothMuscle5.3
Spinalcord5.25
SubthalamicNucleus27.5
SuperiorCervicalGanglion6.65
TemporalLobe34.3
Testis4.2
TestisGermCell4.15
TestisIntersitial4.15
TestisLeydigCell5
TestisSeminiferousTubule4.95
Thalamus5.05
Thymus3.8
Thyroid6.05
Tongue5.75
Tonsil4.8
Trachea4.15
TrigeminalGanglion5.2
Uterus3.85
UterusCorpus5.35
WholeBlood5.4
Wholebrain88.75
colon4.95
pineal_day23.26
pineal_night21.94
retina7.525
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P162068
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala14.23 ± 0.38
Basal Forebrain13.78 ± 0.16
Basal Part of Pons12.12 ± 0.47
Cerebellar Cortex12.48 ± 0.34
Cerebellar Nuclei11.56 ± 0.51
Claustrum12.79 ± 0.81
Epithalamus12.26 ± 0.69
Frontal Lobe13.27 ± 0.63
Globus Pallidus13.55 ± 0.46
Hypothalamus13.09 ± 0.89
Insula13.35 ± 0.4
Limbic Lobe13.39 ± 0.58
Mesencephalon13.53 ± 0.73
Myelencephalon13.43 ± 0.87
Occipital Lobe13.88 ± 0.64
Parietal Lobe13.56 ± 0.51
Pontine Tegmentum13.55 ± 0.51
Striatum14.58 ± 0.35
Subthalamus12.51 ± 0.37
Temporal Lobe13.27 ± 0.51
Thalamus13.64 ± 0.61
White Matter11.06 ± 0.88
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc1a2CBCerebellum49.4
100
Slc1a2CTXCerebral cortex100
100
Slc1a2HIPHippocampal region100
100
Slc1a2HPFHippocampal formation100
100
Slc1a2HYHypothalamus74.87
82.17
Slc1a2LSXLateral septal complex100
100
Slc1a2MBMidbrain83.96
87.88
Slc1a2MYMedulla89.79
95.97
Slc1a2OLFOlfactory bulb100
100
Slc1a2PPons91.78
96.67
Slc1a2PALPallidum69.99
77.71
Slc1a2RHPRetrohippocampal region100
100
Slc1a2sAMYStriatum-like amygdalar nuclei92.83
97.22
Slc1a2STRStriatum97.01
100
Slc1a2STRdStriatum dorsal region94.73
100
Slc1a2STRvStriatum ventral region95.37
98.99
Slc1a2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064490 11 374 384 CLEENLGIDKR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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