AutismKB 2.0

Annotation Detail for SLC1A3


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Basic Information Top
Gene Symbol:SLC1A3 ( EA6,EAAT1,FLJ25094,GLAST,GLAST1 )
Gene Full Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Band: 5p13.2
Quick LinksEntrez ID:6507; OMIM: 600111; Uniprot ID:EAA1_HUMAN; ENSEMBL ID: ENSG00000079215; HGNC ID: 10941
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus113 / 564012200
neonate1 / 3109732
infant4 / 23620169
juvenile0 / 555560 
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor9 / 17290520
gastrointestinal tumor3 / 11936925
germ cell tumor30 / 263845113
glioma14 / 106883130
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia17 / 97250174
normal1257 / 3360307374
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone6 / 7165583
bone marrow4 / 4880181
brain1260 / 11009891144
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus9 / 20209445
eye24 / 211054113
heart6 / 8962666
intestine0 / 2344720 
kidney7 / 21177733
larynx0 / 241450 
liver3 / 20774314
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle2 / 10771518
nerve2 / 15768126
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta7 / 28082524
prostate2 / 18934510
salivary gland3 / 20155148
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis21 / 33044263
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202800_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.45
Adipocyte10.7
AdrenalCortex10.05
Adrenalgland7.65
Amygdala1275.7
Appendix10.6
AtrioventricularNode9.05
BDCA4+_DentriticCells7.35
Bonemarrow9.25
BronchialEpithelialCells8.1
CD105+_Endothelial8.4
CD14+_Monocytes9.05
CD19+_BCells(neg._sel.)8.4
CD33+_Myeloid10.55
CD34+9.65
CD4+_Tcells8.6
CD56+_NKCells9.75
CD71+_EarlyErythroid8
CD8+_Tcells7.6
CardiacMyocytes12
Caudatenucleus567.15
Cerebellum460
CerebellumPeduncles1275.75
CiliaryGanglion8.3
CingulateCortex884.5
Colorectaladenocarcinoma8.25
DorsalRootGanglion8.05
FetalThyroid9.5
Fetalbrain647.3
Fetalliver8.05
Fetallung6.9
GlobusPallidus268.15
Heart12.95
Hypothalamus1424.5
Kidney9.1
Leukemia_chronicMyelogenousK-5627.7
Leukemia_promyelocytic-HL-607.45
Leukemialymphoblastic(MOLT-4)6.6
Liver16.85
Lung9.45
Lymphnode9.75
Lymphoma_burkitts(Daudi)11.4
Lymphoma_burkitts(Raji)12.95
MedullaOblongata464.3
OccipitalLobe1576.75
OlfactoryBulb159.6
Ovary6.5
Pancreas7
PancreaticIslet9.3
ParietalLobe722.3
Pituitary14.65
Placenta8.65
Pons369.6
PrefrontalCortex3791.1
Prostate9.75
Salivarygland7.25
SkeletalMuscle14.7
Skin8.4
SmoothMuscle9.6
Spinalcord671.4
SubthalamicNucleus276.1
SuperiorCervicalGanglion12.35
TemporalLobe363.55
Testis7.3
TestisGermCell6.4
TestisIntersitial7.3
TestisLeydigCell8.75
TestisSeminiferousTubule7.3
Thalamus425.3
Thymus6.5
Thyroid10
Tongue10.35
Tonsil8.5
Trachea7.05
TrigeminalGanglion11.1
Uterus6.7
UterusCorpus8.2
WholeBlood9.2
Wholebrain590.95
colon8.25
pineal_day159.94
pineal_night57.94
retina405.1
small_intestine8.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P250963
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.38 ± 0.34
Basal Forebrain10.35 ± 0.12
Basal Part of Pons9.15 ± 0.24
Cerebellar Cortex9.83 ± 0.48
Cerebellar Nuclei9.4 ± 0.43
Claustrum9.91 ± 0.49
Epithalamus10.41 ± 0.5
Frontal Lobe9.77 ± 0.46
Globus Pallidus10.73 ± 0.42
Hypothalamus9.94 ± 0.25
Insula9.85 ± 0.43
Limbic Lobe9.69 ± 0.54
Mesencephalon9.93 ± 0.48
Myelencephalon9.93 ± 0.58
Occipital Lobe9.98 ± 0.56
Parietal Lobe9.84 ± 0.49
Pontine Tegmentum9.98 ± 0.37
Striatum10.17 ± 0.6
Subthalamus9.58 ± 0.31
Temporal Lobe9.72 ± 0.45
Thalamus9.96 ± 0.41
White Matter9.24 ± 0.33
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064491 11 375 385 CLEENNGVDKR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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