AutismKB 2.0

Annotation Detail for TMEM135


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Basic Information Top
Gene Symbol:TMEM135 ( DKFZp686I1974,FLJ22104 )
Gene Full Name: transmembrane protein 135
Band: 11q14.2
Quick LinksEntrez ID:65084; OMIM: NA; Uniprot ID:TM135_HUMAN; ENSEMBL ID: ENSG00000166575; HGNC ID: 26167
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus14 / 56401224
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor14 / 26384553
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia0 / 972500 
normal107 / 336030731
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow7 / 48801143
brain33 / 110098929
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye6 / 21105428
heart1 / 8962611
intestine3 / 23447212
kidney7 / 21177733
larynx0 / 241450 
liver3 / 20774314
lung4 / 33697411
lymph1 / 4427022
lymph node3 / 9161032
mammary gland4 / 15327126
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid4 / 20539194
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta14 / 28082549
prostate2 / 18934510
salivary gland3 / 20155148
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis17 / 33044251
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus7 / 23287830
vascular28 / 51780540
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222209_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts106.3
Adipocyte191.9
AdrenalCortex11
Adrenalgland13.55
Amygdala20.1
Appendix10.55
AtrioventricularNode7.85
BDCA4+_DentriticCells16.1
Bonemarrow9.15
BronchialEpithelialCells57
CD105+_Endothelial10.3
CD14+_Monocytes8.75
CD19+_BCells(neg._sel.)10.7
CD33+_Myeloid12.65
CD34+19.6
CD4+_Tcells8.8
CD56+_NKCells15.1
CD71+_EarlyErythroid8
CD8+_Tcells9.65
CardiacMyocytes11.6
Caudatenucleus8.45
Cerebellum7.65
CerebellumPeduncles11.8
CiliaryGanglion8.65
CingulateCortex9.45
Colorectaladenocarcinoma8.95
DorsalRootGanglion8
FetalThyroid9.35
Fetalbrain10.5
Fetalliver22.25
Fetallung10.45
GlobusPallidus7.25
Heart13
Hypothalamus19.9
Kidney8.25
Leukemia_chronicMyelogenousK-56252.85
Leukemia_promyelocytic-HL-6036.3
Leukemialymphoblastic(MOLT-4)57.75
Liver13.3
Lung7.85
Lymphnode8.3
Lymphoma_burkitts(Daudi)30.55
Lymphoma_burkitts(Raji)15.55
MedullaOblongata8.45
OccipitalLobe10.2
OlfactoryBulb7.75
Ovary6.7
Pancreas9.55
PancreaticIslet10.55
ParietalLobe10.95
Pituitary30.85
Placenta11.25
Pons9.95
PrefrontalCortex11.9
Prostate12.65
Salivarygland9.8
SkeletalMuscle11.8
Skin7.9
SmoothMuscle27.8
Spinalcord9.95
SubthalamicNucleus9.5
SuperiorCervicalGanglion13.4
TemporalLobe9.6
Testis7.8
TestisGermCell35.2
TestisIntersitial8.9
TestisLeydigCell9.95
TestisSeminiferousTubule8.85
Thalamus9.95
Thymus7.1
Thyroid29.85
Tongue9.95
Tonsil7.65
Trachea13
TrigeminalGanglion10.55
Uterus9.55
UterusCorpus8.95
WholeBlood8.95
Wholebrain9.3
colon46.75
pineal_day18.52
pineal_night18.56
retina13.725
small_intestine90.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P127075
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.78 ± 0.44
Basal Forebrain6.43 ± 0.35
Basal Part of Pons6.21 ± 0.22
Cerebellar Cortex6.01 ± 0.33
Cerebellar Nuclei6 ± 0.29
Claustrum5.78 ± 0.53
Epithalamus6.19 ± 0.41
Frontal Lobe6.22 ± 0.44
Globus Pallidus7.15 ± 0.19
Hypothalamus6.43 ± 0.43
Insula6.59 ± 0.48
Limbic Lobe6.42 ± 0.41
Mesencephalon6.42 ± 0.41
Myelencephalon6.28 ± 0.52
Occipital Lobe6.33 ± 0.42
Parietal Lobe6.36 ± 0.43
Pontine Tegmentum6.39 ± 0.5
Striatum6.63 ± 0.4
Subthalamus5.92 ± 0.26
Temporal Lobe6.32 ± 0.41
Thalamus6.3 ± 0.33
White Matter7.07 ± 0.56
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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