AutismKB 2.0

Annotation Detail for SLC1A4


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Basic Information Top
Gene Symbol:SLC1A4 ( ASCT1,SATT )
Gene Full Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Band: 2p14
Quick LinksEntrez ID:6509; OMIM: 600229; Uniprot ID:SATT_HUMAN; ENSEMBL ID: ENSG00000115902; HGNC ID: 10942
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst0 / 623190 
fetus56 / 56401299
neonate1 / 3109732
infant0 / 236200 
juvenile13 / 55556233
adult115 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor15 / 94178159
cervical tumor4 / 34366116
chondrosarcoma7 / 8282384
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor17 / 26384564
glioma7 / 10688365
head and neck tumor9 / 13630266
kidney tumor3 / 6895943
leukemia11 / 95842114
liver tumor11 / 96359114
lung tumor3 / 10312729
lymphoma22 / 71755306
non-neoplasia9 / 9725092
normal248 / 336030773
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor23 / 124949184
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland7 / 33197210
ascites1 / 4001524
bladder1 / 2975733
blood19 / 123478153
bone7 / 7165597
bone marrow1 / 4880120
brain134 / 1100989121
cervix5 / 48171103
connective tissue19 / 149255127
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye15 / 21105471
heart4 / 8962644
intestine11 / 23447246
kidney8 / 21177737
larynx0 / 241450 
liver14 / 20774367
lung16 / 33697447
lymph18 / 44270406
lymph node6 / 9161065
mammary gland17 / 153271110
mouth10 / 67052149
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta7 / 28082524
prostate5 / 18934526
salivary gland1 / 2015549
skin32 / 210574151
spleen1 / 5395218
stomach5 / 9661951
testis20 / 33044260
thymus13 / 81131160
thyroid0 / 474730 
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus14 / 23287860
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209611_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte3.6
AdrenalCortex3.8
Adrenalgland3.1
Amygdala3.9
Appendix3.7
AtrioventricularNode2.8
BDCA4+_DentriticCells4.3
Bonemarrow3.6
BronchialEpithelialCells3.6
CD105+_Endothelial3.7
CD14+_Monocytes3.9
CD19+_BCells(neg._sel.)3.9
CD33+_Myeloid4.75
CD34+4.65
CD4+_Tcells4
CD56+_NKCells4.35
CD71+_EarlyErythroid3.4
CD8+_Tcells3.5
CardiacMyocytes4.65
Caudatenucleus3.25
Cerebellum2.95
CerebellumPeduncles4.15
CiliaryGanglion2.6
CingulateCortex3.75
Colorectaladenocarcinoma3.65
DorsalRootGanglion2.9
FetalThyroid3.55
Fetalbrain4.25
Fetalliver3.15
Fetallung3.05
GlobusPallidus2.7
Heart4.6
Hypothalamus3.95
Kidney2.9
Leukemia_chronicMyelogenousK-5623.3
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)3.9
Liver4.8
Lung4
Lymphnode3.15
Lymphoma_burkitts(Daudi)4.7
Lymphoma_burkitts(Raji)5.1
MedullaOblongata3.35
OccipitalLobe3.25
OlfactoryBulb2.85
Ovary2.45
Pancreas2.9
PancreaticIslet3.9
ParietalLobe3.85
Pituitary4.45
Placenta3.8
Pons3.5
PrefrontalCortex4.5
Prostate4.25
Salivarygland2.9
SkeletalMuscle5.75
Skin2.8
SmoothMuscle4.15
Spinalcord4.25
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.3
TemporalLobe3.35
Testis3.3
TestisGermCell3.35
TestisIntersitial3.1
TestisLeydigCell3.6
TestisSeminiferousTubule3.15
Thalamus3.7
Thymus2.95
Thyroid4.55
Tongue3.6
Tonsil3.55
Trachea3
TrigeminalGanglion3.85
Uterus2.95
UterusCorpus3.35
WholeBlood4
Wholebrain3.25
colon3.7
pineal_day4.54
pineal_night4.46
retina4.4
small_intestine3.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_575_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.84 ± 0.54
Basal Forebrain4.95 ± 0.49
Basal Part of Pons4.33 ± 0.64
Cerebellar Cortex4.02 ± 0.3
Cerebellar Nuclei4.13 ± 0.58
Claustrum4.58 ± 0.91
Epithalamus4.22 ± 0.64
Frontal Lobe4.5 ± 0.58
Globus Pallidus4.71 ± 0.28
Hypothalamus4.95 ± 0.44
Insula4.72 ± 0.49
Limbic Lobe4.35 ± 0.62
Mesencephalon4.5 ± 0.58
Myelencephalon4.48 ± 0.65
Occipital Lobe4.11 ± 0.52
Parietal Lobe4.42 ± 0.63
Pontine Tegmentum4.58 ± 0.61
Striatum4.95 ± 0.48
Subthalamus3.93 ± 0.8
Temporal Lobe4.56 ± 0.57
Thalamus4.49 ± 0.53
White Matter2.9 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc1a4HYHypothalamus23.6
19.8
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007048 27 502 528 SEEETSPLVTHQNPAGPVASAPELESK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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