Annotation Detail for SLC6A11
Basic Information Top
| Gene Symbol: | SLC6A11 ( GAT-3,GAT3,GAT4 ) |
|---|---|
| Gene Full Name: | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 |
| Band: | 3p25.3 |
| Quick Links | Entrez ID:6538; OMIM: 607952; Uniprot ID:S6A11_HUMAN; ENSEMBL ID: ENSG00000132164; HGNC ID: 11044 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.657405
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 2 / 564012 | 3 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 4 / 1939121 | 2 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 12 / 3360307 | 3 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 7 / 1100989 | 6 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 1 / 24145 | 41 | |
| liver | 2 / 207743 | 9 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 2 / 330442 | 6 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 207048_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 9.4 | |
| Adipocyte | 8.5 | |
| AdrenalCortex | 9.75 | |
| Adrenalgland | 7.5 | |
| Amygdala | 8.75 | |
| Appendix | 9.35 | |
| AtrioventricularNode | 7.55 | |
| BDCA4+_DentriticCells | 9.45 | |
| Bonemarrow | 9.2 | |
| BronchialEpithelialCells | 8.35 | |
| CD105+_Endothelial | 9.05 | |
| CD14+_Monocytes | 9.1 | |
| CD19+_BCells(neg._sel.) | 9.05 | |
| CD33+_Myeloid | 10.75 | |
| CD34+ | 10.9 | |
| CD4+_Tcells | 9.55 | |
| CD56+_NKCells | 9.95 | |
| CD71+_EarlyErythroid | 8.25 | |
| CD8+_Tcells | 8.25 | |
| CardiacMyocytes | 16.75 | |
| Caudatenucleus | 7.7 | |
| Cerebellum | 7.05 | |
| CerebellumPeduncles | 10.25 | |
| CiliaryGanglion | 6.2 | |
| CingulateCortex | 9.05 | |
| Colorectaladenocarcinoma | 8.7 | |
| DorsalRootGanglion | 8.9 | |
| FetalThyroid | 8.5 | |
| Fetalbrain | 8.4 | |
| Fetalliver | 7.65 | |
| Fetallung | 6.75 | |
| GlobusPallidus | 7.8 | |
| Heart | 15.7 | |
| Hypothalamus | 9.05 | |
| Kidney | 7.25 | |
| Leukemia_chronicMyelogenousK-562 | 7.85 | |
| Leukemia_promyelocytic-HL-60 | 7.45 | |
| Leukemialymphoblastic(MOLT-4) | 6.75 | |
| Liver | 12.05 | |
| Lung | 9.35 | |
| Lymphnode | 7 | |
| Lymphoma_burkitts(Daudi) | 11.05 | |
| Lymphoma_burkitts(Raji) | 14.55 | |
| MedullaOblongata | 7.75 | |
| OccipitalLobe | 7.7 | |
| OlfactoryBulb | 7.05 | |
| Ovary | 5.95 | |
| Pancreas | 7.25 | |
| PancreaticIslet | 9.45 | |
| ParietalLobe | 9.5 | |
| Pituitary | 10.05 | |
| Placenta | 8.6 | |
| Pons | 8.25 | |
| PrefrontalCortex | 10.1 | |
| Prostate | 9.85 | |
| Salivarygland | 7.55 | |
| SkeletalMuscle | 17.45 | |
| Skin | 8 | |
| SmoothMuscle | 9.4 | |
| Spinalcord | 9.3 | |
| SubthalamicNucleus | 8.25 | |
| SuperiorCervicalGanglion | 11.75 | |
| TemporalLobe | 8.85 | |
| Testis | 7.35 | |
| TestisGermCell | 7.05 | |
| TestisIntersitial | 7.45 | |
| TestisLeydigCell | 8.7 | |
| TestisSeminiferousTubule | 7.2 | |
| Thalamus | 9 | |
| Thymus | 6.4 | |
| Thyroid | 11.15 | |
| Tongue | 9.05 | |
| Tonsil | 9.35 | |
| Trachea | 7.1 | |
| TrigeminalGanglion | 8.9 | |
| Uterus | 6.9 | |
| UterusCorpus | 11.75 | |
| WholeBlood | 9.35 | |
| Wholebrain | 7.15 | |
| colon | 8.75 | |
| pineal_day | 10.7 | |
| pineal_night | 10.98 | |
| retina | 10.725 | |
| small_intestine | 8.45 | |
- Probe name: CUST_584_PI416408490
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.37 ± 0.82 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.7 ± 0.49 | |
| Basal Part of Pons | 2.7 ± 0.46 | |
| Cerebellar Cortex | 3.2 ± 0.56 | |
| Cerebellar Nuclei | 3.86 ± 0.79 | |
| Claustrum | 3.69 ± 0.57 | |
| Epithalamus | 3.92 ± 0.6 | |
| Frontal Lobe | 3.54 ± 0.78 | |
| Globus Pallidus | 5.84 ± 0.62 | |
| Hypothalamus | 4.1 ± 0.72 | |
| Insula | 3.5 ± 0.49 | |
| Limbic Lobe | 3.16 ± 0.74 | |
| Mesencephalon | 4.02 ± 0.8 | |
| Myelencephalon | 3.77 ± 0.83 | |
| Occipital Lobe | 4.01 ± 0.66 | |
| Parietal Lobe | 3.84 ± 0.91 | |
| Pontine Tegmentum | 3.96 ± 0.9 | |
| Striatum | 2.92 ± 0.95 | |
| Subthalamus | 4.19 ± 0.35 | |
| Temporal Lobe | 3.61 ± 0.86 | |
| Thalamus | 4.41 ± 0.76 | |
| White Matter | 2.47 ± 0.41 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Slc6a11 | CB | Cerebellum | 26.4 |  |
| 32.33 | | |||
| Slc6a11 | CTX | Cerebral cortex | 29.01 | |
| 20.32 | | |||
| Slc6a11 | HIP | Hippocampal region | 27.6 | |
| 27.65 | | |||
| Slc6a11 | HPF | Hippocampal formation | 30.45 | |
| 26.79 | | |||
| Slc6a11 | HY | Hypothalamus | 95.57 | |
| 100 | | |||
| Slc6a11 | LSX | Lateral septal complex | 52.79 | |
| 41.56 | | |||
| Slc6a11 | MB | Midbrain | 91.66 | |
| 99.8 | | |||
| Slc6a11 | MY | Medulla | 73.94 | |
| 84.24 | | |||
| Slc6a11 | OLF | Olfactory bulb | 78.26 | |
| 90.47 | | |||
| Slc6a11 | P | Pons | 73.1 | |
| 83.35 | | |||
| Slc6a11 | PAL | Pallidum | 85.25 | |
| 89.74 | | |||
| Slc6a11 | RHP | Retrohippocampal region | 34.52 | |
| 25.62 | | |||
| Slc6a11 | sAMY | Striatum-like amygdalar nuclei | 70.68 | |
| 69.65 | | |||
| Slc6a11 | STR | Striatum | 23.24 | |
| 18.71 | | |||
| Slc6a11 | STRd | Striatum dorsal region | 10.92 | |
| 7.88 | | |||
| Slc6a11 | STRv | Striatum ventral region | 25.91 | |
| 17.93 | | |||
| Slc6a11 | TH | Thalamus | 68.31 | |
| 75.02 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00878371 | 7 | 76 | 82 | FPYLCYK | Peptide Atlas |