AutismKB 2.0

Annotation Detail for SLC11A1


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Basic Information Top
Gene Symbol:SLC11A1 ( LSH,NRAMP,NRAMP1 )
Gene Full Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Band: 2q35
Quick LinksEntrez ID:6556; OMIM: 600266; Uniprot ID:NRAM1_HUMAN; ENSEMBL ID: ENSG00000018280; HGNC ID: 10907
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia5 / 9584252
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal128 / 336030738
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood52 / 123478421
bone0 / 716550 
bone marrow1 / 4880120
brain23 / 110098920
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye8 / 21105437
heart0 / 896260 
intestine6 / 23447225
kidney3 / 21177714
larynx1 / 2414541
liver2 / 2077439
lung31 / 33697491
lymph0 / 442700 
lymph node2 / 9161021
mammary gland3 / 15327119
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen7 / 53952129
stomach0 / 966190 
testis1 / 3304423
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210423_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.9
Adipocyte5.05
AdrenalCortex5.4
Adrenalgland4.6
Amygdala6.25
Appendix6.55
AtrioventricularNode4.2
BDCA4+_DentriticCells19.65
Bonemarrow22.9
BronchialEpithelialCells4.75
CD105+_Endothelial9.9
CD14+_Monocytes211.95
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid180.25
CD34+6.5
CD4+_Tcells5.3
CD56+_NKCells21.2
CD71+_EarlyErythroid6.35
CD8+_Tcells4.6
CardiacMyocytes7.2
Caudatenucleus4.55
Cerebellum4.1
CerebellumPeduncles5.85
CiliaryGanglion3.9
CingulateCortex5.1
Colorectaladenocarcinoma7.05
DorsalRootGanglion4.35
FetalThyroid4.95
Fetalbrain5.15
Fetalliver5.6
Fetallung6.5
GlobusPallidus3.7
Heart7.05
Hypothalamus5.65
Kidney4.15
Leukemia_chronicMyelogenousK-5624.55
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)4
Liver8.05
Lung177.3
Lymphnode4.3
Lymphoma_burkitts(Daudi)6.4
Lymphoma_burkitts(Raji)7.45
MedullaOblongata4.6
OccipitalLobe4.6
OlfactoryBulb4.8
Ovary3.45
Pancreas4.05
PancreaticIslet5.7
ParietalLobe5.25
Pituitary5.85
Placenta7.65
Pons5.05
PrefrontalCortex6.3
Prostate13.75
Salivarygland4
SkeletalMuscle5.8
Skin3.9
SmoothMuscle5.95
Spinalcord5.45
SubthalamicNucleus4.5
SuperiorCervicalGanglion6.05
TemporalLobe4.85
Testis4.4
TestisGermCell4.25
TestisIntersitial4.7
TestisLeydigCell5
TestisSeminiferousTubule5.2
Thalamus5.2
Thymus5.65
Thyroid8.15
Tongue5.1
Tonsil5.6
Trachea4.2
TrigeminalGanglion5.8
Uterus4.55
UterusCorpus4.5
WholeBlood265.35
Wholebrain4.4
colon5.05
pineal_day6.24
pineal_night6.02
retina6.2
small_intestine4.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P76831
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.1 ± 0.91
Basal Forebrain1.68 ± 0.59
Basal Part of Pons1.9 ± 0.49
Cerebellar Cortex1.95 ± 0.7
Cerebellar Nuclei2.06 ± 0.48
Claustrum1.99 ± 0.61
Epithalamus1.9 ± 0.67
Frontal Lobe1.9 ± 0.71
Globus Pallidus2.87 ± 0.33
Hypothalamus1.58 ± 0.72
Insula2.06 ± 0.67
Limbic Lobe1.98 ± 0.71
Mesencephalon1.93 ± 0.76
Myelencephalon1.91 ± 0.72
Occipital Lobe1.72 ± 0.85
Parietal Lobe1.86 ± 0.7
Pontine Tegmentum1.85 ± 0.72
Striatum1.63 ± 0.69
Subthalamus1.81 ± 0.7
Temporal Lobe1.8 ± 0.73
Thalamus1.72 ± 0.66
White Matter3.53 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc11a1CBCerebellum2
3.82
Slc11a1CTXCerebral cortex0.68
1.17
Slc11a1HIPHippocampal region0.34
0.43
Slc11a1HPFHippocampal formation0.48
0.64
Slc11a1HYHypothalamus0.03
0.07
Slc11a1LSXLateral septal complex0
0
Slc11a1MBMidbrain0.26
0.37
Slc11a1MYMedulla0.22
0.26
Slc11a1OLFOlfactory bulb0.75
2
Slc11a1PPons0.18
0.3
Slc11a1PALPallidum0.2
0.33
Slc11a1RHPRetrohippocampal region0.69
0.89
Slc11a1sAMYStriatum-like amygdalar nuclei1.58
2.33
Slc11a1STRStriatum0.26
0.32
Slc11a1STRdStriatum dorsal region0.13
0.12
Slc11a1STRvStriatum ventral region0.11
0.08
Slc11a1THThalamus1.19
2.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NRAM1_HUMAN_24 12 24 35 PTSPGPQQAPPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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